Abstract As an intractable health threat, neuropathic pain is now a key problem in clinical therapy, which can be caused by lesions affecting the peripheral nervous systems. 1,8-cineole natural monoterpene cyclic ether present eucalyptus and has been reported to exhibit anti-inflammatory antioxidant effects. Research shown that inhibits P2X3 receptor-mediated pains dorsal root ganglion. The P2X2 receptors participate transmission of algesia nociception information primary sensory neurons. In...

Transplantation of Schwann cells (SCs) can promote axonal regeneration and formation the myelin sheath, reduce inflammation, repair to damaged nerve. Our previous studies have shown that transplantation free or micro-encapsulated olfactory ensheathing relieve neuropathic pain. There are no related reports regarding whether SCs alleviate pain mediated by P2X2/3 receptors. In present study, we in alginic acid transplanted them into region surrounding injured sciatic nerve rat model chronic...

Abstract Diagnosis of renal fibrosis can only be verified by kidney biopsy, but biomarkers for non-invasive evaluation remain unsatisfactory. Patients with often have abnormalities the lymphatic vascular system and associated immune function. We describe here a marker as candidate biomarker fibrosis. After assessing grading scores, testing serum soluble vessel endothelial hyaluronan receptor1 (sLYVE1) level, collecting clinical information, association between sLYVE1 was analyzed. Logistic...

Rationale: Central nervous system infections (CNSIs) are one of the most serious complications after neurosurgery, especially carbapenem-resistant bacterial meningitis. Owing to poor blood-brain barrier permeability antibiotics, treatment CNSIs by intraventricular (IVT) administration is becoming a hot topic in clinical research. Currently, caused Klebsiella pneumoniae mainly based on injection an antibiotic combined with or more other systemic intravenous (IV) whereas there few case reports...

The Nuclear factor erythroid 2-related 2 (NRF2) transcription has attracted much attention in the context of neurological diseases. However, none studies have systematically clarified this field's research hotspots and evolution rules.To investigate hotspots, patterns, future trends field recent years.We conducted a comprehensive literature search Web Science Core Collection database using following methods: (((((TS=(NFE2 L2)) OR TS=(Nfe2 L2 protein, mouse)) TS=(NF-E2-Related Factor 2))...

Objective Early prediction of long-term outcomes in patients with sepsis-induced cardiorenal syndrome (CRS) remains a great challenge clinical practice. Herein, we aimed to construct nomogram and machine learning model for predicting the 1-year mortality risk CRS. Methods This retrospective study enrolled 340 diagnosed CRS Shanghai Tongji Hospital between January 2015 May 2019, as discovery cohort. Two predictive models, model, were used predict mortality. The prognostic variables develop...

The correlation of the expression ankyrin repeat domain (ANKRD) family members with renal cell carcinoma prognosis was investigated.

The vitcamphor was synthesized from camphor as starting materials via the bromination, followed by esterification, reduction, hydrolisis and oxidation. structure of target compound confirmed <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> H NMR xmlns:xlink="http://www.w3.org/1999/xlink">13</sup> C NMR, overall yield increased 6% to 12%. purity tide over 96 %. anti-inflammatory activity determined vascular permeability mice rat...

Aim: This paper aims at providing more information of people with hemophilia for targeted treatment. Methods: 1149 are surveyed in 45 units, and then established by EpiData software. The number 9 age intervals the male female is analyzed Population Pyramid Pareto Analysis. Results: It found that appearing every interval. Relative to patients, patients extremely rare. Of 1134 relative frequencies ranked first (23.0%), second (17.4%), third (17.2%) 7 - 12, 2 3, 13 18 years old, respectively,...

Objective To study the etiological classification method in hemophillia.Methods From February 2005 to May 2010,500 hemophillia patients were included this Shaanxi Medical University Hematology Institute.The activity of coagulation factor was tested by one stage assay.The antibodies FⅧ and FIX Bethesda assay.According diagnostic criteria thrombosis homeostasis conference 2000,the etiology classified as four types,as flowers:Congential hereditary hemophilia,congential non-hereditary...

To evaluate the efficacy and safety of Shengxue mixture combined with intraosseous blood infusion for treatment aplastic anemia patients.From 2011 to 2015, Institute diseases Shaanxi Medical University admitted 53 patients anemia. The were treated shengxue 200 ml, orally, twice a day. Stanozolol tablets, Adult 2 mg, three times day, mycophenolate mofetil 1.0 g, Intraosseous following medicine administered in patients: recombinant human EPO 10000 U, G-CSF 450 µg, IL-11 4.5 dexmethasone 20...

Objective To explore the microencapsulated olfactory ensheathing cell (MC-OECs) transplantation on treatment of neuropathic pain, and to observe L4-5 spinal cord P2X2, P2X3 receptors expression effects. Methods The differential adherent methods were used culture cells (OECs) from bulb SD rats September 2014 July 2015. The 9th generations OECs identified by immunofluorescence staining, then produce MC-OECs. Forty-eight healthy regardless males females randomly divided into control...

急性肾损伤（AKI）是临床常见危重症，缺血是其最常见原因之一。近年来，越来越多的研究提示肠道菌群和缺血性AKI存在联系。本文主要对缺血性AKI导致的肠道菌群改变及其意义、肠道菌群介导的细胞免疫反应（巨噬细胞、树突状细胞和T细胞）对缺血性AKI的影响及所涉及的信号分子（短链脂肪酸、D-丝氨酸和内毒素），以及包括短链脂肪酸、肠源性尿毒症毒素吸附和抗生素在内的基于肠道菌群的靶向治疗等问题进行综述。缺血性AKI缺乏特异性预防和治疗措施，肠道菌群研究将为其预防和治疗提供新靶点、新途径。

&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; Sepsis-induced cardiorenal syndrome (sepsis-induced CRS) is a devastating medical condition that frequently associated with high fatality rate. In this study, we aimed to develop an individualized nomogram may help clinicians assess 30-day mortality risk in patients diagnosed sepsis-induced CRS. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; A total of 340 CRS admitted from January 2015 May 2019 Shanghai Tongji Hospital were used as...