A5101644989- Fungal Biology and Applications
- Mycorrhizal Fungi and Plant Interactions
- Plant Pathogens and Fungal Diseases
- Heavy Metal Exposure and Toxicity
- Aquaculture disease management and microbiota
- Fermentation and Sensory Analysis
- Dementia and Cognitive Impairment Research
- Plant tissue culture and regeneration
- Agronomic Practices and Intercropping Systems
- RNA modifications and cancer
- Alzheimer's disease research and treatments
- Agricultural Science and Fertilization
- Fungal and yeast genetics research
- Mitochondrial Function and Pathology
- Allelopathy and phytotoxic interactions
- Cancer Mechanisms and Therapy
- Food Quality and Safety Studies
- Spinal Cord Injury Research
- Agriculture, Soil, Plant Science
- Cancer Genomics and Diagnostics
- Biocrusts and Microbial Ecology
- Forest, Soil, and Plant Ecology in China
- Neonatal and fetal brain pathology
- Genetic factors in colorectal cancer
- Musculoskeletal pain and rehabilitation
Shanghai Academy of Agricultural Sciences
2009-2025
Jiangxi Fisheries Research Institute
2023-2024
China National Salt Industry Corporation (China)
2024
Wenzhou Medical University
2024
Dongyang People's Hospital
2024
Dalian University of Technology
2024
Ministry of Agriculture and Rural Affairs
2024
Tianjin Medical University Cancer Institute and Hospital
2024
Chinese Academy of Fishery Sciences
2022-2023
Nanjing Agricultural University
2023
Chromosomal microarray analysis is the gold standard for copy-number variant (CNV) detection in prenatal and postnatal diagnosis. We aimed to determine whether next-generation sequencing (NGS) technology could be an alternative method CNV routine clinical application.Genome-wide (>50 kb) was performed on a multicenter group of 570 patients using low-coverage whole-genome pipeline. These samples were referred chromosomal analysis; CNVs (i.e., pathogenic CNVs, pCNVs) classified according...
Spinal cord is extremely vulnerable to ischemia-reperfusion (I/R) injury, and mitochondrion the most crucial interventional target. Rapamycin can promote autophagy exert neuroprotective effects in several diseases of central nervous system. However, impact rapamycin via modulating mitophagy apoptosis by after spinal injury remains unclear. This study was undertaken investigate potential role mitochondria-dependent using (SCIRI) mouse model. We found that significantly (p<0.05) enhanced...
Aim To explore the role of hub gene Transforming Growth Factor Beta Induced (TGFBI) in Intervertebral disc degeneration (IDD) pathogenesis and its regulatory relationship with Membrane Associated Ring-CH-Type Finger 8 (MARCHF8). Background IDD is a prevalent musculoskeletal disorder leading to spinal pathology. Despite ubiquity impact, effective therapeutic strategies remain be explored. Objective Identify key modules associated understand impact TGFBI on nucleus pulposus (NP) cell behavior,...
The study aimed to compare the frequency of neuropsychiatric symptoms (NPS) across declining memory continuum, from normal aging, subjective cognitive impairment (SCI), and mild (MCI) Alzheimer's disease (AD), explore clinical correlates NPS.In a clinic, 157 subjects (46 AD patients, 38 MCI individuals, 24 SCI subjects, 49 controls) completed neurobehavioral assessments with Neuropsychiatric Inventory (NPI). significance each NPI domain was defined as an item score ≥4.Clinically significant...
A sensitive and selective ultra high performance liquid chromatography with tandem mass spectrometry method was established validated for the simultaneous determination of hydroxy-α-sanshool, hydroxy-β-sanshool, hydroxy-γ-sanshool in rat plasma after subcutaneous intravenous administration an extract pericarp Zanthoxylum bungeanum Maxim. Piperine used as internal standard. The analytes were extracted from by liquid-liquid extraction ethyl acetate separated on a Thermo Hypersil GOLD C18...
Most of the sequenced wood-rotting edible mushroom produce fruiting body at relatively low temperatures. Little information has been known about high-temperature mushroom. Here, we performed de novo sequencing and assembly genome a Pleurotus giganteus from monokaryotic strain zhudugu2 using Illumina Pac-Bio CLR technologies. P. giganteus, also as Zhudugu in China, is well-known culinary that widely distributed cultivated Southeast Asia, South Asia. The consists 40.00 Mb 27 contigs with...
Lysyl oxidase (LOX) plays a crucial role in the maintenance of extracellular matrix stability and could participate vascular remodeling associated with cardiovascular diseases. A novel polymorphism LOX gene, G473A (rs1800449), was identified. The objective this study to investigate association between susceptibility coronary artery diseases (CADs) Chinese population. variant detected by polymerase chain reaction-restriction fragment length 656 CAD cases 718 age-matched controls. Frequencies...
Objective: Epilepsy is a chronic disease that places heavy burden on caregivers. Previous studies have shown caregivers of epilepsy patients often experience anxiety and depression; however, few comprehensive assessed their sleep quality family function. Based the current understanding depression state in children with epilepsy, we further explored caregivers' function evaluated predictors Methods: In this cross-sectional online anonymous survey, sent an questionnaire to who visited our...
As a key element in the T-helper 17 (Th17) cell-mediated inflammatory process, interleukin-23 receptor (IL-23R) may play crucial role pathogenesis of atherosclerosis. Single nucleotide polymorphisms (SNPs) IL-23R have been studied several diseases. However, its association with coronary artery disease (CAD) remains unclear. This study examined whether genetic were associated susceptibility to CAD. Two SNPs, rs1884444 and rs6682925, genotyped 462 CAD patients 486 healthy controls. Data showed...
Cognitive dysfunction is a very severe consequence of diabetes, but the underlying causes are still unclear. Recently, cerebellum was reported to play an important role in learning and memory. Since long-term depression (LTD) primary cellular mechanism for cerebellar motor learning, we aimed explore LTD pathways diabetic rats therapeutic effect gastrodin. Diabetes induced by single injection streptozotocin into adult Sprague-Dawley rats. Motor ability assessed beam walk test. Pathological...
Abstract Background Recently, increasing innovations improved the accuracy of next generation sequencing (NGS) data. However, validation all NGS variants increased cost and turn‐around time clinical diagnosis, therefore limited further development applications. We aimed to comprehensively assess necessity validating variants. Methods Validation data 7,601 involving 1,045 genes were collected from 5,190 samples sequenced by one five targeted capture panels two chemistries, respectively. These...
Pleurotus giganteus is a commercially cultivated high-temperature mushroom. Investigating the molecular mechanism of fruiting body development will help us to better understand regulation substrates and energy in this process. However, little information has been reported on nutrients P. body. In present study, climate chamber, comparative transcriptome, proteome, nutritional analysis bodies were performed. Our results revealed that Cytochrome P450 monooxygenases hydrophobin proteins play...
Agronomic traits are key components in variety protection, cultivar development, and the formulation of DUS (distinct, uniform, stable) test guidelines. P. giganteus is an increasingly popular commercially promising edible macrofungi. In this study, both mycelial performance fruiting body characters 15 Pleurotus strains were investigated. The temperature gradient culture indicated that, although most achieved optimal growth between 24 28 °C, a statistical difference rates adaptability among...
The sampling technique is commonly used in research investigations to more accurately estimate data with greater precision, at a lower cost and less time. In plant DUS (distinctness, uniformity, stability) testing, many quantitative characteristic usually need be obtained through individual measurements. However, there currently no scientific method for determining the appropriate size. minimum number of testing samples was calculated based on theory sample size descriptive studies validated...
1. This study evaluated the toxicity of chronic exposure to low-level cadmium (Cd) in rats using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). Forty male Sprague-Dawley were randomly assigned four groups, namely, control group, low-dose group (0.13 mg/kg·bw), middle-dose (0.8 mg/kg·bw) and high-dose (4.89 mg/kg·bw). The continuously received CdCl2 via drinking water for 24 weeks. Serum samples collected metabonomics analysis. data generated from UPLC-MS was analysed...
This research aims to determine whether quercetin has protective effects against the toxicity of acrylamide (AA) using metabonomic technology. Randomly, rats were assigned into a control group, AA treatment group and plus group. Quercetin administered daily via gavage drinking water for 16 weeks, respectively. To detect profiles urine, ultra-performance liquid chromatography/mass spectrometry was used. A total 15 metabolites, including biomarkers exposure (GAMA, AAMA, iso-AAMA) (quercetin...
The main polyphenols in mung bean (Vigna radiata L.) seed (MBS), an edible legume with various biological activities, are C-glycosyl flavones (vitexin, isovitexin, isovitexin-6″-O-α-l-glucoside, and dulcinoside). In our study, a validated ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed to quantitate the concentrations of four from MBS extracts plasma tissues rats successfully applied study their pharmacological profile tissue...