A5049827614- Fungal Biology and Applications
- Mycorrhizal Fungi and Plant Interactions
- Genomics and Phylogenetic Studies
- Plant Pathogens and Fungal Diseases
- Plant Reproductive Biology
- Probiotics and Fermented Foods
- Bacteriophages and microbial interactions
- Fungal and yeast genetics research
- Gut microbiota and health
- Microbial Community Ecology and Physiology
- Microbial Metabolites in Food Biotechnology
- Protist diversity and phylogeny
- Chromosomal and Genetic Variations
- Bacterial Genetics and Biotechnology
- Microbial Metabolism and Applications
- Escherichia coli research studies
- RNA and protein synthesis mechanisms
- Food Allergy and Anaphylaxis Research
- Biofuel production and bioconversion
- CRISPR and Genetic Engineering
- Fermentation and Sensory Analysis
- Enzyme-mediated dye degradation
- Subterranean biodiversity and taxonomy
- Slime Mold and Myxomycetes Research
- Plant tissue culture and regeneration
Chinese University of Hong Kong
2015-2024
Hong Kong Science and Technology Parks Corporation
2020-2022
Chinese University of Hong Kong, Shenzhen
2014
University of Hong Kong
1998
Shatin Hospital
1996
University of California, Davis
1989-1994
Emory University
1994
National Center for Infectious Diseases
1994
The mushroom Coprinopsis cinerea is a classic experimental model for multicellular development in fungi because it grows on defined media, completes its life cycle 2 weeks, produces some 10 8 synchronized meiocytes, and can be manipulated at all stages by mutation transformation. 37-megabase genome of C. was sequenced assembled into 13 chromosomes. Meiotic recombination rates vary greatly along the chromosomes, retrotransposons are absent large regions with low levels meiotic recombination....
Background The human gut microbiota has profound influence on host metabolism and immunity. This study characterized the fecal in patients with nonalcoholic steatohepatitis (NASH). relationship between changes hepatic steatosis was also studied. Methods Fecal of histology-proven NASH healthy controls analyzed by 16S ribosomal RNA pyrosequencing. were from a previously reported randomized trial probiotic treatment. Proton-magnetic resonance spectroscopy performed to monitor intrahepatic...
In bacteria, small regulatory non-coding RNAs (sRNAs) are the most abundant class of posttranscriptional regulators.They involved in diverse processes including quorum sensing, stress response, virulence and carbon metabolism.Recent developments high-throughput techniques, such as genomic tiling arrays RNA-Seq, have allowed efficient detection characterization bacterial sRNAs.However, a comprehensive repository to host sRNAs their annotations is not available.Existing databases suffer from...
Bacteria, archaea and fungi play crucial roles in wetland biogeochemical processes. However, little is known about their community structure, dynamics interactions subtropical coastal wetlands. Here, we examined communities of the three kingdoms mangrove mudflat sediments a using Ion Torrent amplicon sequencing co-occurrence network analysis. Bacterial, archaeal fungal comprised mainly members from phyla Proteobacteria Bacteroidetes, Bathyarchaeota Euryarchaeota, Ascomycota, respectively....
Background Tuberculosis (TB) remains a global threat in the 21st century. Traditional studies of disease are focused on single pathogen Mycobacterium tuberculosis. Recent have revealed associations some diseases with an imbalance microbial community. Characterization TB microbiota could allow better understanding disease. Methodology/Principal Findings Here, sputum infection was examined by using 16S rRNA pyrosequencing. A total 829,873 high-quality sequencing reads were generated from 22...
Abstract Background The transition from the vegetative mycelium to primordium during fruiting body development is most complex and critical developmental event in life cycle of many basidiomycete fungi. Understanding molecular mechanisms underlying this process has long been a goal research on basidiomycetes. Large scale assessment expressed transcriptomes these stages will facilitate generation more comprehensive picture mushroom process. In study, we coupled 5'-Serial Analysis Gene...
The "developmental hourglass" concept suggests that intermediate developmental stages are most resistant to evolutionary changes and differences between species arise through divergence later in development. This high conservation during middevelopment is illustrated by the "waist" of hourglass it represents a low probability change. Earlier molecular surveys both on animals plants have shown genes expressed at waist stage more ancient conserved their expression. existence such has not been...
The phylum Cnidaria represents a close outgroup to Bilateria and includes familiar animals including sea anemones, corals, hydroids, jellyfish. Here we report genome sequencing assembly for true jellyfish Sanderia malayensis Rhopilema esculentum. homeobox gene clusters are characterised by interdigitation of Hox, NK, Hox-like genes revealing an alternate pathway ANTP class dispersal intact three ParaHox cluster. mitochondrial genomes linear but, unlike in Hydra, do not detect nuclear copies,...
Abstract Whole genome duplication (WGD) has occurred in relatively few sexually reproducing invertebrates. Consequently, the WGD that common ancestor of horseshoe crabs ~135 million years ago provides a rare opportunity to decipher evolutionary consequences duplicated invertebrate genome. Here, we present high-quality assembly for mangrove crab Carcinoscorpius rotundicauda (1.7 Gb, N50 = 90.2 Mb, with 89.8% sequences anchored 16 pseudomolecules, 2 n 32), and resequenced tri-spine Tachypleus...
ABSTRACT The effect of different substrates and various developmental stages (mycelium growth, primordium appearance, fruiting-body formation) on laccase production in the edible mushroom Lentinula edodes was studied. cap mature showed highest activity, activity not stimulated by some well-known inducers or sawdust. For our molecular studies, two genomic DNA sequences, representing allelic variants L. lac1 gene, were isolated, sequence analysis demonstrated that encodes a putative...
As adulterated and substituted Chinese medicinal materials are common in the market, therapeutic effectiveness of such cannot be guaranteed. Identification at species-, strain- locality-levels, therefore, is required for quality assurance/control medicine. This review provides an informative introduction to DNA methods authentication materials. Technical features examples based on sequencing, hybridization polymerase chain reaction (PCR) described their suitability different identification...
Esophageal squamous cell carcinoma (ESCC) is the most common histological subtype of esophageal cancer worldwide. Patients with ESCC display an altered microbiota compared healthy individuals; however, little known about gut in ESCC.Here, we characterized fecal 15 patients and 16 control subjects using 16S rRNA gene sequencing.After controlling for potential confounders, significant alterations both taxonomic functional composition were observed. By contrast, alpha diversity did not...
Diet modification is a common compensation strategy to promote swallowing safety in patients with difficulties. The International Dysphagia Standardisation Initiative (IDDSI) guideline provides qualitative descriptions on texture-modified food and thickened liquid. This study aimed establish quantitative textural rheological data different IDDSI levels based Chinese ingredients dishes. Textural properties of 226 samples various textures 93 liquid consistencies were obtained using texture...
Kueishan Island is a young volcanic island in the southernmost edge of Okinawa Trough northeastern part Taiwan. A cluster hydrothermal vents located off southeastern tip at water depths between 10 and 80 m. This paper presents results first study on microbial communities bottom sediments collected from shallow‐water Island. Small‐subunit ribosomal RNA gene‐based high‐throughput 454 pyrosequencing was used to characterize assemblages bacteria, archaea, small eukaryotes sediment samples...
The filamentous fungus Aspergillus oryzae is used in soy sauce koji making due to its high productivity of hydrolytic enzymes. In this study, we compared the genomes and transcriptomes an industrial strain RD2 a with decreased fermentation performance TS2, aiming explain their phenotypic differences at molecular level. Under regulation conidiation conditions, enhanced enzyme production flavor precursor formation described complete expression profile necessary maintain desirable performance....
// Suet-Yan Kwan 1, 2 , Xuanjin Cheng 3 Yvonne T.M. Tsang 1 Jong-Sun Choi 4 Suet-Ying Daisy I. Izaguirre Hoi-Shan David M. Gershenson Kwong-Kwok Wong Department of Gynecologic Oncology and Reproductive Medicine, The University Texas MD Anderson Cancer Center, Houston, TX, USA Biology Program, Graduate School Biomedical Sciences at Life Sciences, Chinese Hong Kong, Shatin, New Territories, Kong Center for Anti-cancer Companion Diagnostics, Institutes Entrepreneurial BioConvergence, Seoul...