A5009346472- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Optical Coherence Tomography Applications
- Subterranean biodiversity and taxonomy
- Advanced Fluorescence Microscopy Techniques
- Marine Ecology and Invasive Species
- Marine Biology and Ecology Research
- Protist diversity and phylogeny
- Orbital Angular Momentum in Optics
- Digital Holography and Microscopy
- Ubiquitin and proteasome pathways
- Parasite Biology and Host Interactions
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Developmental Biology and Gene Regulation
- Marine Biology and Environmental Chemistry
- Environmental DNA in Biodiversity Studies
- Lipid metabolism and biosynthesis
- interferon and immune responses
University of Cambridge
2024
MRC Mitochondrial Biology Unit
2024
Medical Research Council
2024
Chinese University of Hong Kong
2020-2021
University of St Andrews
2015-2018
Sands
2018
Abstract Whole genome duplication (WGD) has occurred in relatively few sexually reproducing invertebrates. Consequently, the WGD that common ancestor of horseshoe crabs ~135 million years ago provides a rare opportunity to decipher evolutionary consequences duplicated invertebrate genome. Here, we present high-quality assembly for mangrove crab Carcinoscorpius rotundicauda (1.7 Gb, N50 = 90.2 Mb, with 89.8% sequences anchored 16 pseudomolecules, 2 n 32), and resequenced tri-spine Tachypleus...
Abstract Light-sheet fluorescence microscopy has emerged as a powerful platform for 3-D volumetric imaging in the life sciences. Here, we introduce an important step towards its use deep inside biological tissue. Our new technique, based on digital holography, enables delivery of light-sheet through multimode optical fibre – element with extremely small footprint, yet permitting complex control light transport processes within. We show that this approach supports some most advanced methods...
The Myriapoda, composed of millipedes and centipedes, is a fascinating but poorly understood branch life, including species with highly unusual body plan range unique adaptations to their environment. Here, we sequenced assembled 2 chromosomal-level genomes the Helicorthomorpha holstii (assembly size = 182 Mb; shortest scaffold/contig length needed cover 50% genome [N50] 18.11 Mb mainly on 8 pseudomolecules) Trigoniulus corallinus 449 Mb, N50 26.78 17 pseudomolecules). Unique genomic...
Abstract Whole genome duplication (WGD) has occurred in relatively few sexually reproducing invertebrates. Consequently, the WGD that common ancestor of horseshoe crabs ~135 million years ago provides a rare opportunity to decipher evolutionary consequences duplicated invertebrate genome. Here, we present high-quality assembly for mangrove crab Carcinoscorpius rotundicauda (1.7Gb, N50 = 90.2Mb, with 89.8% sequences anchored 16 pseudomolecules, 2n 32), and resequenced tri-spine Tachypleus...
The diversity of mechanisms and capacity for regeneration across the Metazoa present an intriguing challenge in evolutionary biology, impacting on burgeoning field regenerative medicine. Broad taxonomic sampling is essential to improve our understanding regeneration, studies outside traditional model organisms have proved extremely informative. Within historically understudied Spiralia, Annelida impressive variety tractable systems. biomeralizing, blastema-less head appendage (operculum)...
The Pax3/7 transcription factor family is integral to developmental gene networks contributing important innovations in vertebrate evolution, including the neural crest. basal chordate lineage of amphioxus ideally placed understand dynamics regulatory network evolution that produced these novelties. We report here discovery cephalochordate possesses two genes, Pax3/7a and Pax3/7b. tandem duplication ancestral all extant amphioxus, occurring both Asymmetron Branchiostoma, but originated after...
Abstract Aberration of mitochondrial function is a shared feature many human pathologies, characterised by changes in metabolic flux, cellular energetics, morphology, composition, and dynamics the network. While some these serve as compensatory mechanisms to maintain homeostasis, their chronic activation can permanently affect metabolism signalling, ultimately impairing cell function. Here, we use Drosophila melanogaster model expressing proofreading-deficient mtDNA polymerase (POLγ exo- )...
Abstract The Myriapoda including millipedes and centipedes is of major importance in terrestrial ecology nutrient recycling. Here, we sequenced assembled two chromosomal-scale genomes Helicorthomorpha holstii (182 Mb, N50 18.11 Mb mainly on 8 pseudomolecules) Trigoniulus corallinus (449 26.78 15 pseudomolecules). Unique defense systems, genomic features, patterns gene regulation millipedes, not observed other arthropods, are revealed. Millipedes possesses a unique ozadene defensive gland...
Light-sheet fluorescence microscopy is quickly becoming one of the cornerstone imaging techniques in biology as it provides rapid, three-dimensional sectioning specimens at minimal levels phototoxicity. It very appealing to bring this unique combination properties into an endoscopic setting and be able perform optical deep tissues. Current approaches for delivery light-sheet illumination are based on single-mode fibre terminated by cylindrical gradient index lens. Such configuration...