A5038117842- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Autophagy in Disease and Therapy
- Fungal and yeast genetics research
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Redox biology and oxidative stress
- Genetic and Kidney Cyst Diseases
- Exercise and Physiological Responses
- Metabolism and Genetic Disorders
- Epigenetics and DNA Methylation
- Amyotrophic Lateral Sclerosis Research
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Advanced Glycation End Products research
- Lipid metabolism and biosynthesis
Karolinska University Hospital
2024
Karolinska Institutet
2020-2024
Universitat de Lleida
2012-2018
Biomedical Research Institute of Lleida
2012-2018
Abstract The oxidative phosphorylation system 1 in mammalian mitochondria plays a key role transducing energy from ingested nutrients 2 . Mitochondrial metabolism is dynamic and can be reprogrammed to support both catabolic anabolic reactions, depending on physiological demands or disease states. Rewiring of mitochondrial intricately linked metabolic diseases promotes tumour growth 3–5 Here, we demonstrate that oral treatment with an inhibitor transcription (IMT) 6 shifts whole-animal...
Yeast frataxin homolog (Yfh1) is the orthologue of human frataxin, a mitochondrial protein whose deficiency causes Friedreich Ataxia. Yfh1 activates Aft1, transcription factor governing iron homeostasis in yeast cells. Although mechanisms causing this activation are not completely understood, it assumed that may be caused by iron-sulfur deficiency. However, several evidences indicate Aft1 occurs absence Besides, also leads to metabolic remodeling (mainly consisting shift from respiratory...
Lung adenocarcinoma is a common aggressive cancer and leading cause of mortality worldwide. Here, we report an important in vivo role for mitochondrial DNA (mtDNA) copy number during lung progression the mouse. We found that tumors induced by KRAS
Abstract The highly conserved CHCHD2 and CHCHD10 are small mitochondrial proteins residing in the intermembrane space. Recently, mutations genes have been linked to severe disorders, including Parkinson’s disease amyotrophic lateral sclerosis. In cultured cells, a fraction of oligomerize form high molecular weight complex unknown function. Here, we generated whole-body Chchd2 knockout mouse investigate vivo role its protein complex. We show that is crucial for sustaining full motor capacity,...
Abstract Aberration of mitochondrial function is a shared feature many human pathologies, characterised by changes in metabolic flux, cellular energetics, morphology, composition, and dynamics the network. While some these serve as compensatory mechanisms to maintain homeostasis, their chronic activation can permanently affect metabolism signalling, ultimately impairing cell function. Here, we use Drosophila melanogaster model expressing proofreading-deficient mtDNA polymerase (POLγ exo- )...
Summary The oxidative phosphorylation (OXPHOS) system in mammalian mitochondria plays a key role harvesting energy from ingested nutrients 1, 2 . Mitochondrial metabolism is very dynamic and can be reprogrammed to support both catabolic anabolic reactions, depending on physiological demands or disease states 3, 4 Rewiring of mitochondrial intricately linked metabolic diseases 5, 6 also necessary promote tumour growth 7–11 Here, we demonstrate that per oral treatment with an inhibitor...