A5034571232- Mitochondrial Function and Pathology
- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Microtubule and mitosis dynamics
- Chronic Myeloid Leukemia Treatments
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Genomics and Chromatin Dynamics
- Cellular transport and secretion
- RNA and protein synthesis mechanisms
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- Pancreatic function and diabetes
- RNA modifications and cancer
- Sirtuins and Resveratrol in Medicine
- Enzyme Structure and Function
- Cytomegalovirus and herpesvirus research
- Amino Acid Enzymes and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Tuberculosis Research and Epidemiology
- Biochemical effects in animals
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
Lead Discovery Center (Germany)
2013-2024
Max Planck Institute of Molecular Physiology
2006-2008
Max Planck Society
2005-2006
Abstract The oxidative phosphorylation system 1 in mammalian mitochondria plays a key role transducing energy from ingested nutrients 2 . Mitochondrial metabolism is dynamic and can be reprogrammed to support both catabolic anabolic reactions, depending on physiological demands or disease states. Rewiring of mitochondrial intricately linked metabolic diseases promotes tumour growth 3–5 Here, we demonstrate that oral treatment with an inhibitor transcription (IMT) 6 shifts whole-animal...
Abstract Pioneer transcription factors are proteins that induce cellular identity transitions by binding to inaccessible regions of DNA in nuclear chromatin. They contribute chromatin opening and recruit other regulatory elements. The structural features dynamics modulating their interaction with nucleosomes still unresolved. From a combination experiments molecular simulations, we reveal here how the pioneer factor master regulator pluripotency, Oct4, interprets enhances nucleosome...
Overcoming drug-resistance and the subsequent relapse that often occurs with monotherapy is crucial in treatment of acute myeloid leukemia. We here demonstrate therapy-resistant leukemia initiating cells can be targeted using a novel inhibitor mitochondrial transcription (IMT). The compound inhibits RNA polymerase activity sensitizes resistant population to induction apoptosis. In vitro studies on IMT prevents cell proliferation, together selective BCL-2 inhibitor, venetoclax, induces...
Replication of human cytomegalovirus (HCMV) is characterized by a tight virus-host cell interaction. Cyclin-dependent protein kinases (CDKs) are functionally integrated into viral gene expression and modification. The HCMV-encoded kinase pUL97 acts as CDK ortholog showing structural functional similarities. Recently, we reported an interaction between with subset host cyclins, in particular cyclin T1. Here, describe at even higher affinity B1. As striking feature, the B1 proved to be...
Mitochondria harbor the oxidative phosphorylation (OXPHOS) system, which under aerobic conditions produces bulk of cellular adenosine triphosphate (ATP). The mitochondrial genome encodes key components OXPHOS and it is transcribed by RNA polymerase, POLRMT. levels transcription correlate with respiratory activity cell. Therefore, compounds that can increase or decrease gene may be useful for fine-tuning metabolism could used to treat metabolic diseases certain forms cancer. We here report...
Overcoming drug-resistance and the subsequent relapse that often occurs with monotherapy is crucial in treatment of acute myeloid leukemia. We here demonstrate therapy-resistant leukemia initiating cells can be targeted using a novel inhibitor mitochondrial transcription (IMT). The compound inhibits RNA polymerase activity sensitizes resistant population to induction apoptosis. In vitro studies on IMT prevents cell proliferation, together selective BCL-2 inhibitor, venetoclax, induces...
Abstract Mitochondria contain a unique DNA genome (mtDNA) that encodes number of key components the respiratory chain. Levels mtDNA gene expression correlate with metabolic requirements mammalian cells. Recently, role mitochondrial function for development and progression cancer has been highlighted. Oncogenes have identified to redirect functions increase cell survival. Increased levels oxidative phosphorylation also implicated in resistance towards drugs. In agreement this notion,...
Abstract Pioneer transcription factors are proteins that induce cellular identity transitions by binding to inaccessible regions of DNA in nuclear chromatin. They contribute chromatin opening and recruit other regulatory elements. The structural features dynamics modulating their interaction with nucleosomes still unresolved. From a combination experiments molecular simulations, we reveal here how the pioneer factor master regulator pluripotency, Oct4, interprets enhances nucleosome...
Summary The oxidative phosphorylation (OXPHOS) system in mammalian mitochondria plays a key role harvesting energy from ingested nutrients 1, 2 . Mitochondrial metabolism is very dynamic and can be reprogrammed to support both catabolic anabolic reactions, depending on physiological demands or disease states 3, 4 Rewiring of mitochondrial intricately linked metabolic diseases 5, 6 also necessary promote tumour growth 7–11 Here, we demonstrate that per oral treatment with an inhibitor...
Abstract Overcoming drug-resistance and the subsequent relapse that often occurs with monotherapy is crucial in treatment of acute myeloid leukemia. We here demonstrate therapy-resistant leukemia initiating cells can be targeted using a novel inhibitor mitochondrial transcription (IMT). The compound inhibits RNA polymerase activity sensitizes resistant population to induction apoptosis. In vitro studies on IMT prevents cell proliferation, together selective BCL-2 inhibitor, venetoclax,...