A5061617553- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Attention Deficit Hyperactivity Disorder
- Obsessive-Compulsive Spectrum Disorders
- Functional Brain Connectivity Studies
- Child Development and Digital Technology
- Face Recognition and Perception
- Behavioral and Psychological Studies
- Genomic variations and chromosomal abnormalities
- Congenital heart defects research
- Family and Disability Support Research
- Child Nutrition and Feeding Issues
- Multisensory perception and integration
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Tactile and Sensory Interactions
- Child and Adolescent Psychosocial and Emotional Development
- Child and Animal Learning Development
- Neural and Behavioral Psychology Studies
- Treatment of Major Depression
- Anesthesia and Neurotoxicity Research
- Hearing Loss and Rehabilitation
- Neurogenetic and Muscular Disorders Research
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
Icahn School of Medicine at Mount Sinai
2016-2025
Child Health and Development Institute
2021-2025
Simons Foundation
2024
Mount Sinai Health System
2022
Center for Autism and Related Disorders
2019-2021
Mount Sinai Hospital
2016-2021
Mount Sinai Hospital
2017-2021
Allen Institute for Brain Science
2021
Yale University
2013-2019
Maine School of Science and Mathematics
2017
Autism spectrum disorders (ASD) form a continuum of neurodevelopmental disorders, characterized by deficits in communication and reciprocal social interaction, as well repetitive behaviors restricted interests. Sensory disturbances are also frequently reported clinical autobiographical accounts. However, surprisingly few empirical studies have the fundamental features sensory multisensory processing ASD. The current study is structured to test for potential differences temporal function ASD...
Autism spectrum disorders (ASD) are characterized by deficits in social reciprocity and communication, as well repetitive behaviors restricted interests. Unusual responses to sensory input disruptions the processing of both unisensory multisensory stimuli have also frequently been reported. However, specific aspects that disrupted ASD yet be fully elucidated. Recent published work has shown children with can integrate low-level audiovisual stimuli, but do so over an extended range time when...
In the rubber hand illusion, perceived ownership can be transferred to a after synchronous visual and tactile stimulation. Perceived body self–other relation are foundational for development of self-awareness, imitation, empathy, which all affected in autism spectrum disorders (ASD). We examined illusion children with without ASD. Children ASD were initially less susceptible than comparison group, yet showed effects 6 minutes. Delayed susceptibility may result from atypical multisensory...
Atypical perceptual processing in autism spectrum disorder (ASD) is well documented. In addition, growing evidence supports the hypothesis that an excitatory/inhibitory neurochemical imbalance might underlie ASD. Here we investigated putative behavioral consequences of context visual motion perception. As stimulus size increases, typical observers exhibit marked impairments perceiving high-contrast stimuli. This result, termed "spatial suppression," believed to reflect inhibitory...
Abstract Background The prevalence of depression is elevated in individuals with autism spectrum disorder (ASD) compared to the general population, yet reasons for this disparity remain unclear. While social deficits central ASD may contribute depression, it uncertain whether interaction behavior themselves or individuals’ introspection about their behaviors are more impactful. Although anterior cingulate cortex (ACC) frequently implicated ASD, and functioning, unknown if explains...
Unmasking the neural basis of neurodevelopmental disorders, such as autism spectrum disorders (ASD), requires studying functional connectivity during childhood when cognitive skills develop. A magnetic resonance imaging (fcMRI) analysis was performed on data collected Go/NoGo task performance from 24 children ages 8–12 years (12 with ASD; 12 controls matched age and intellectual functioning). We investigated left right inferior frontal cortex (IFC; BA 47), key regions for response...
Background Restricted interests are a class of repetitive behavior in autism spectrum disorders ( ASD ) whose intensity and narrow focus often contribute to significant interference with daily functioning. While numerous neuroimaging studies have investigated executive circuits as putative neural substrates behavior, recent work implicates affective restricted interests. We sought explore the role determine how distinguished from hobbies or typical development. Methods compared group...
One hypothesis for the social deficits that characterize autism spectrum disorders (ASD) is diminished neural reward response to interaction and attachment. Prior research using established monetary paradigms as a test of non-social compare with may involve confounds in ability individuals ASD utilize symbolic representation money abstraction required interpret gains. Thus, useful addition our understanding circuitry includes characterization primary rewards.We asked 17 children 18 without...
Autism spectrum disorder (ASD) and schizophrenia (SZ) are heterogenous neurodevelopmental disorders that overlap in symptom presentation. The purpose of this study was to specify overlapping domains identify symptoms can reliably differentiate adults with ASD (n = 53), SZ 39), typical development (TD; n 40). All participants regardless diagnosis were administered gold-standard diagnostic assessments characteristics including the Diagnostic Observation Schedule (ADOS-2) Positive Negative...
Sensory processing alterations are highly prevalent in autism spectrum disorder (ASD). Neurobiologically‐based theories of ASD propose that abnormalities the temporal aspects sensory input could underlie core symptoms ASD. For example, rapid auditory is critical for speech perception, and language difficulties central to social communication deficits defining disorder. This study assessed visual abilities tested their relation symptoms. 53 children (26 ASD, 27 TD) completed psychophysical...
Individuals with Phelan-McDermid syndrome (PMS) present a wide range of developmental, medical, cognitive and behavioral abnormalities. Previous literature has begun to elucidate genotype-phenotype associations that may contribute the spectrum features. Here, we report results in cohort 170 individuals PMS. Genotypes were defined as Class I deletions (including SHANK3 only or ARSA and/or ACR RABL2B), II (all other deletions) sequence variants. Phenotype data derived prospectively from direct...
Abstract Background DDX3X syndrome is a recently identified genetic disorder that accounts for 1–3% of cases unexplained developmental delay and/or intellectual disability (ID) in females, and associated with motor language delays, autism spectrum (ASD). To date, the published phenotypic characterization this has primarily relied on medical record review; addition, behavioral dimensions have not been fully explored. Methods We carried out multi-day, prospective, detailed phenotyping 14...
Abstract Functional magnetic resonance imaging was used to examine functional anatomy of attention social (eye gaze) and nonsocial (arrow) communicative stimuli in late childhood a disorder defined by atypical processing stimuli, Autism Spectrum Disorders (ASD). Children responded target word (‘LEFT’/‘RIGHT’) the context distracting arrow or averted gaze pointing direction that congruent, incongruent, neutral (bar without arrowheads, central relative word. Despite being irrelevant task, both...
Autism spectrum disorder (ASD) has been characterized by atypical socio-communicative behavior, sensorimotor impairment and abnormal neurodevelopmental trajectories. DTI used to determine the presence nature of abnormality in white matter integrity that may contribute behavioral phenomena characterize ASD. Although patterns sensory responding ASD are well documented literature, much less is known about neural networks associated with aberrant processing. To address roles basic sensory,...
While allowing for rapid recruitment of large samples, online research relies heavily on participants' self-reports neuropsychiatric traits, foregoing the clinical characterizations available in laboratory settings. Autism spectrum disorder (ASD) is one example which validity such an approach remains elusive. Here we compared 56 adults with ASD recruited person and evaluated by clinicians to matched samples through platform (Prolific; high autistic traits low traits) via self-reported...
Abstract A default mode network of brain regions is known to demonstrate coordinated activity during the resting state. While well characterized in adults, few investigations have focused upon its development. We scanned 9–13‐year‐old children with diffusion tensor imaging and resting‐state functional magnetic resonance imaging. identified networks using Independent Component Analysis tested whether connectivity between medial prefrontal cortex (mPFC) posterior cingulate (PCC) depends...