A5009416336- Cerebral Palsy and Movement Disorders
- Botulinum Toxin and Related Neurological Disorders
- Stroke Rehabilitation and Recovery
- Family and Disability Support Research
- Infant Development and Preterm Care
- Muscle activation and electromyography studies
- Balance, Gait, and Falls Prevention
- Spinal Cord Injury Research
- Neonatal and fetal brain pathology
- Prosthetics and Rehabilitation Robotics
- Neurogenetic and Muscular Disorders Research
- Nerve Injury and Rehabilitation
- Children's Physical and Motor Development
- EEG and Brain-Computer Interfaces
- Motor Control and Adaptation
- Health and Medical Research Impacts
- Diabetic Foot Ulcer Assessment and Management
- Traumatic Brain Injury Research
- Hip disorders and treatments
- Delphi Technique in Research
- Autism Spectrum Disorder Research
- Neuroscience and Neural Engineering
- Lower Extremity Biomechanics and Pathologies
- Musculoskeletal Disorders and Rehabilitation
- Foot and Ankle Surgery
National Institutes of Health Clinical Center
2016-2025
National Institutes of Health
2015-2024
Northern Arizona University
2018
Shirley Ryan AbilityLab
2017
Methodist Rehabilitation Center
2017
VA Boston Healthcare System
2017
Harvard University
2017
Rehabilitation Hospital of Indiana
2017
Indiana University – Purdue University Indianapolis
2017
Medical University of South Carolina
2017
For a variety of reasons, the definition and classification cerebral palsy (CP) need to be reconsidered. Modern brain imaging techniques have shed new light on nature underlying injury studies neurobiology pathology associated with development further explored etiologic mechanisms. It is now recognized that assessing extent activity restriction part CP evaluation people without should not included in rubric. Also, previous definitions given sufficient prominence non-motor neurodevelopmental...
Although weakness has been identified in cerebral palsy (CP) isolated muscle groups, the magnitude of multiple muscles and patterns across joints have not documented. The maximum voluntary contraction eight groups lower extremities 15 children with spastic diplegia, hemiplegia, 16 age-matched peers was determined using a hand-held dynamometer. Children diplegia were shown to be weaker than all tested, as hemiplegia on involved side, strength differences also noted uninvolved side. Weakness...
Cerebral palsy (CP) is the most common childhood physical disability. Early intervention for children younger than 2 years with or at risk of CP critical. Now that an evidence-based guideline early accurate diagnosis exists, there a need to summarize effective, CP-specific and conduct new trials harness plasticity improve function increase participation. Our recommendations apply primarily high CP, aged 0 years.To systematically review best available evidence about interventions across 9...
SUMMARY Fourteen ambulatory children with spastic diplegia participated in a bilateral quadriceps. strengthening program an attempt to decrease the amount of knee crouch during gait. Each chid exercised three times week for six weeks using free ankle weights at load 65 per cent maximum. A normal comparison group 25 was also tested under identical conditions. Children cerebral palsy were significantly weaker quadriceps and hamstrings muscle groups than controls. Quadriceps strength increased...
This prospective longitudinal multicenter study of ambulatory children with cerebral palsy (CP) examined changes in outcome tool score over time, responsiveness, and used a systematic method for defining minimum clinically important differences (MCIDs). Three hundred eighty‐one participants CP (Gross Motor Function Classification System [GMFCS] Levels I–III; age range 4–18y, mean 11y [SD 4y 4mo]; 265 diplegia, 116 hemiplegia; 230 males, 151 females). At baseline follow‐up at least 1 year...
Despite evidence of weakness in children with cerebral palsy, the use strength training this population remains controversial.Fourteen spastic diplegia, ranging age from 6 to 14 years (X = 9.1, SD 2.5), participated a bilateral quadriceps femoris muscle strengthening program.The exercised three times per week for weeks using ankle weights at loads approximately 65% each child's maximum isotonic force production. The maximal voluntary contraction muscles was measured before, midpoint of, and...
Inadequate physical fitness is a major problem affecting the function and health of children with cerebral palsy (CP). Lack optimal activity may contribute to development secondary conditions associated CP such as chronic pain, fatigue, osteoporosis. The purpose this article highlight content recommendations Pediatrics Research Summit developed foster collaborative research in area. Two components fitness—muscle strength cardiorespiratory fitness—were emphasized. Although there evidence...
Although trihexyphenidyl is used clinically to treat both primary and secondary dystonia in children, limited evidence exists support its effectiveness, particularly disorders such as cerebral palsy. A prospective, open-label, multicenter pilot trial of high-dose was conducted 23 children aged 4 15 years with palsy judged have impairing function the dominant upper extremity. All were given at increasing doses over a 9-week period up maximum 0.75 mg/kg/d. Trihexyphenidyl subsequently tapered...
A longitudinal study over a mean of 32 months was conducted on 18 subjects with spastic diplegia, ranging in age from 4 to 14 years. Three-dimensional gait analyses were performed compare the temporal and kinematic data across two time intervals. The comparison revealed deterioration stability evidenced by increases double support decreases single growth (p < 0.05). Kinematic analysis loss excursion about knee, ankle, pelvis Additionally, passive range-of-motion decrease popliteal angle In...
This study aimed to explore the limitations of Ashworth scale for measuring spasticity. An isokinetic dynamometer quantify resistance passive stretch and surface EMG was used verify if a response occurred and, so, at what joint angle. The authors sought determine which components (magnitude, rate change, onset angle stretch, or velocity dependence) were most related scores motor function in cerebral palsy (CP). Twenty-two individuals with spastic CP (11 males, 11 females; mean age 11.9...
Progressive resistance exercise (PRE) is a method of increasing the ability muscles to generate force. However, effectiveness and safety PRE for clients physical therapists are not well known. The purpose this article review evidence on positive negative effects as therapy intervention. Electronic databases were searched systematic reviews any relevant randomized trials published after last available review. search yielded 18 under major areas therapy: cardiopulmonary, musculoskeletal,...
The ability to walk contributes considerably physical health and overall well-being, particularly in children with motor disability, is therefore prioritized as a rehabilitation goal. However, half of ambulatory cerebral palsy (CP), the most prevalent childhood movement disorder, cease adulthood. Robotic gait trainers have shown positive outcomes initial studies, but these clinic-based systems are limited short-term programs insufficient length maintain improved function lifelong disability...
Computer simulations have demonstrated that excessive hip and knee flexion during gait, as frequently seen in ambulatory children with cerebral palsy (CP), can reduce the ability of muscles to provide antigravity support increase tendency internally rotate thigh. These findings suggest therapies for improving upright posture gait also may internal rotation.The goal this study was determine whether strength training diminish degree crouched, rotated spastic diplegic CP.This a pilot...
Muscle architecture is known to be predictive of muscle function. However, it unknown whether this relationship similar in children and adolescents with without cerebral palsy (CP).The objective study was determine the rectus femoris (RF) vastus lateralis (VL) muscles maximum voluntary knee extensor torque CP these measures were related activity participation levels.A case-control design used.Eighteen participants (mean age=12.0 years, SD=3.2) at Gross Motor Function Classification System...
Accumulating evidence suggests cortical circuits may contribute to control of human locomotion. Here, noninvasive electroencephalography (EEG) recorded from able-bodied volunteers during a novel treadmill walking paradigm was used assess neural correlates walking. A systematic processing method, including recently developed subspace reconstruction algorithm, reduced movement-related EEG artifact prior independent component analysis and dipole source localization. We quantified activity while...