A5024767587- Cerebral Palsy and Movement Disorders
- Botulinum Toxin and Related Neurological Disorders
- Stroke Rehabilitation and Recovery
- Muscle activation and electromyography studies
- Family and Disability Support Research
- Neurogenetic and Muscular Disorders Research
- Infant Development and Preterm Care
- Muscle Physiology and Disorders
- Prosthetics and Rehabilitation Robotics
- Children's Physical and Motor Development
- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Assistive Technology in Communication and Mobility
- Motor Control and Adaptation
- Neurological disorders and treatments
- Balance, Gait, and Falls Prevention
- Lower Extremity Biomechanics and Pathologies
- Neonatal and fetal brain pathology
- Scoliosis diagnosis and treatment
- Glycogen Storage Diseases and Myoclonus
- Hip and Femur Fractures
- Inflammatory Myopathies and Dermatomyositis
- Advanced Neuroimaging Techniques and Applications
- Tendon Structure and Treatment
- Pharmacological Effects and Assays
Orthopaedic Institute for Children
2014-2024
University of California, Los Angeles
2015-2024
United Cerebral Palsy
2007-2021
Motion Control (United States)
2013
Orthopaedic Hospital
2001-2012
Los Angeles Medical Center
1996-1999
University of Calgary
1999
UCLA Medical Center
1995
Inadequate physical fitness is a major problem affecting the function and health of children with cerebral palsy (CP). Lack optimal activity may contribute to development secondary conditions associated CP such as chronic pain, fatigue, osteoporosis. The purpose this article highlight content recommendations Pediatrics Research Summit developed foster collaborative research in area. Two components fitness—muscle strength cardiorespiratory fitness—were emphasized. Although there evidence...
Normal selective voluntary motor control (SVMC) can be defined as the ability to perform isolated joint movement without using mass flexor/extensor patterns or undesired at other joints, such mirroring. SVMC is an important determinant of function, yet a valid, reliable assessment tool lacking. The Selective Control Assessment Lower Extremity (SCALE) clinical developed quantify in patients with cerebral palsy (CP). This paper describes development, utility, validation, and interrater...
Background and Purpose. The rapid growth of the elderly population has resulted in a corresponding rise number individuals who experience disability during their lifetimes. purpose this study was to test usefulness four established clinical measures balance, gait, subjective perceptions fear falling as screening methods for referring community-dwelling living residential care facilities detailed physical therapy evaluation possible intervention. Subjects. subjects were convenience sample 53...
Multiple impairments contribute to motor deficits in spastic cerebral palsy (CP). Selective voluntary control (SVMC), namely isolation of joint movement upon request, is important, but frequently overlooked. This study evaluated the proximal distal distribution SVMC impairment among lower extremity joints.Using a recently developed tool, Control Assessment Lower Extremity (SCALE), we hip, knee, ankle, subtalar joint, and toes cross-sectional, observational 47 participants with spastic,...
The majority of published functional outcome data for tumor megaprostheses comes in the form subjective scores. Sparse objective exist demonstrating results, activity levels, and efficiency gait after endoprosthetic reconstruction patients treated orthopaedic tumors. Patients embarking on massive surgical operations, often setting debilitating medical therapies, face mortality a myriad unknowns. Objective outcomes provide with reasonable expectations means to envision life treatment. also...
The Bobath neurodevelopmental treatment approach advised against the use of resistive exercise, as proponents felt that increased effort would increase spasticity. purpose this study was to test premise performance exercises with maximum efforts will spasticity in people cerebral palsy (CP). Spasticity, present study, defined a velocity-dependent hyperexcitability muscle stretch reflex.Twenty-four subjects spastic diplegic form CP (mean age=11.4 years, SD=3.0, range=7-17) and 12 without...
Background Effective interventions to improve and maintain strength (force-generating capacity) endurance are needed for children with cerebral palsy (CP). Objective This study was performed examine the effects of a stationary cycling intervention on muscle strength, locomotor endurance, preferred walking speed, gross motor function in spastic diplegic CP. Design phase I randomized controlled trial single blinding. Setting The were community-based outpatient physical therapy clinics. Outcome...
The sensitivity of the pendulum test to variation in spasticity persons with spastic cerebral palsy (CP) was tested 30 participants CP and 10 without (controls) (mean age 13.8 years). were classified into three groups, normal 15.9 years), mild/moderate (13.0 or severe (23.0 years) muscle tone, as assessed clinically using a modified Ashworth scale. Joint motion during measured an electrogoniometer. Muscle relaxation confirmed surface EMG. Outcome measures from (1) number oscillations, (2)...
Evidence-based recommendations regarding which exercise tests to use in children and adolescents with cerebral palsy (CP) are lacking. This makes it very difficult for therapists researchers choose the appropriate exercise-related outcome measures this group. study aimed identify a core set of CP.Fifteen experts (10 physical therapists/researchers five physiologists; three from Netherlands, two USA, one UK, Canada, four Australia) participated Delphi survey took stages achieve consensus....
In the past, effortful exercises were considered inappropriate for children with spastic cerebral palsy (CP) due to concern that they would escalate abnormalities including spasticity and abnormal movement patterns. Current scientific evidence indicates these concerns unfounded therapeutic interventions focused on muscle strengthening can lead improved functional ability. However, few studies have examined potential benefits of cardiorespiratory fitness in this patient population. The...
<b>Background: </b> Albuterol is a beta-2 agonist that has been demonstrated to increase muscle strength in studies animals and humans. Based on pilot study of extended-release albuterol Repetabs children with dystrophinopathies, the authors conducted randomized, double-blind, placebo-controlled crossover design. <b>Methods: Fourteen boys Duchenne or Becker muscular dystrophy, 6 11 years old, completed two treatment periods (albuterol placebo), 12 weeks each, separated by 12-week washout...
ABSTRACT Introduction Natural history studies for Duchenne muscular dystrophy (DMD) have not included measures of community ambulation. Methods Step activity (SA) monitors quantified ambulation in 42 boys (ages 4–16 years) with DMD serial enrollment up to 5 years by using a repeated‐measures mixed model. Additionally, data were compared 10‐meter walk/run (10mWR) speed determine validity and sensitivity. Results There significant declines average strides/day percent strides at moderate, high...
The authors conducted a randomized, crossover, double-blind, placebo-controlled pilot study of albuterol in nine boys with dystrophinopathies. Primary outcomes were 1) isometric knee extensor and flexor strength; 2) manual muscle testing (MMT). Isometric strength MMT scores significantly higher patients taking vs placebo. Therefore, 12-week treatment extended-release may increase A larger, randomized is necessary to confirm these results.
Cerebral palsy is associated with osteopenia, increased fracture risk, short stature, and decreased muscle mass, whereas GH therapy bone mineral density (BMD) linear growth improvement in body composition.We conducted a pilot study to evaluate the effect of 18 months on spinal BMD, growth, biochemical markers, functional measures children cerebral palsy.The was randomized control trial, from 2002-2005 at University California, Los Angeles, Orthopedic Hospital's Center for Palsy.Patients...
Aim The aim of this study was to assess health‐related quality life (HRQOL) following a stationary cycling intervention in children with cerebral palsy (CP). Method This phase I multisite randomized controlled trial single blinding. HRQOL evaluated using the Pediatric Quality Life Inventory SF15 (PedsQL; children) and Outcomes Data Collection Instrument (PODCI; parent proxy) before after 3‐month intervention. Sixty‐two (29 male, 33 female; mean age 11y; range 7–18y) spastic diplegic CP,...
Background and Purpose. The purpose of this study was to determine the effectiveness an individualized physical therapy mobility training program on gait, balance, functional performance elderly individuals living in residential care facilities. Subjects. Twenty-seven with impaired balance difficulty performing at least one activity participated study. subjects ranged age from 71 97 years (X̅=87.1, SD=6.7). Methods. Balance gait speed were assessed baseline following that consisted exercises...
The aim of this study was to determine whether prednisone and deflazacort play a different role in child behavior perceived health related psychosocial quality life ambulant boys with Duchenne Muscular Dystrophy. As part prospective natural-history study, parents sixty-seven DMD (27 taking prednisone, 15 deflazacort, 25 were steroid naïve) completed the Child Behavior Checklist (CBCL) for assessment behavioral, emotional social problems both PedsQL™4.0 generic core scale short form. Boys had...