A5079044997- Cerebral Palsy and Movement Disorders
- Botulinum Toxin and Related Neurological Disorders
- Children's Physical and Motor Development
- Infant Development and Preterm Care
- Inclusion and Disability in Education and Sport
- Family and Disability Support Research
- Injury Epidemiology and Prevention
- Burn Injury Management and Outcomes
- Neurogenetic and Muscular Disorders Research
- Nerve Injury and Rehabilitation
- Maternal and fetal healthcare
- Hip disorders and treatments
- Clostridium difficile and Clostridium perfringens research
- Sports Performance and Training
- Sports injuries and prevention
- Stroke Rehabilitation and Recovery
- Hemispheric Asymmetry in Neuroscience
- Disaster Response and Management
- Nail Diseases and Treatments
- Lower Extremity Biomechanics and Pathologies
- Gut microbiota and health
- Homicide, Infanticide, and Child Abuse
- Antimicrobial Resistance in Staphylococcus
- Obesity, Physical Activity, Diet
- Attention Deficit Hyperactivity Disorder
The University of Western Australia
2015-2024
University of Cape Town
2016-2017
Center for Health, Exercise and Sport Sciences
2005-2012
University of Vermont
1997
Johns Hopkins University
1993
Port Moresby General Hospital
1983-1984
King Edward Memorial Hospital
1982
Royal Women's Hospital
1970-1971
The 2013 Infection Prevention and Control (IP&C) Guideline for Cystic Fibrosis (CF) was commissioned by the CF Foundation as an update of 2003 CF. During past decade, new knowledge challenges provided following rationale to develop updated IP&C strategies this unique population: 1. need integrate relevant recommendations from evidence-based guidelines published since into practices . These included Centers Disease (CDC)/Healthcare Practices Advisory Committee (HICPAC), World Health...
Motor impairment is not currently included in the diagnostic criteria or evaluation of autism. This reflects lack large‐scale studies demonstrating its prominence to advocate for change. We examined prevalence motor difficulties at time diagnosis a large sample children with autism utilizing standardized assessment, and relationship between difficulties, core symptomology, other prominent clinical features. Vineland Adaptive Behavior Scales were administered from Western Australian Register...
Hamstrings injury/reinjury is common, but functional reasons for this remain unclear. This study identified bilateral differences in swing phase running biomechanics and isokinetic strength, between the previously hamstring-injured uninjured limbs of male athletes involved sprint-based sports.Athletes, injury-free during testing, underwent three-dimensional motion analyses to determine joint kinematics kinetics submaximal sprinting. Various hip knee strength tests were performed bilaterally...
Aim With evidence for an atrophic effect of botulinum toxin type A (Bo NT ‐A) documented in typically developing muscles, this study investigated the immediate morphological alterations muscles children with cerebral palsy ( CP ) after Bo ‐A treatment. Method Fifteen (10 males, five females; age range 5–11y, mean 8y 5mo, SD 1y 10mo) spastic diplegic [Gross Motor Function Classification System Levels I n =9) and II =6)] receiving B o ‐ injections spasticity management were included. None was...
Introduction: Children diagnosed with Developmental Coordination Disorder (DCD) present a variety of impairments in fine and gross motor function, which impact on their activity participation settings. This research aimed to determine if 10-week group-based Cognitive Orientation Daily Occupational Performance (CO-OP) intervention improved outcome measures across the impairment, levels International Classification Functioning, Disability Health (ICF) framework. Methods: In this...
The need to identify strategies that facilitate involvement in physical activity for children and youth with disabilities is recognised as an urgent priority. This study aimed describe the association between context, mechanisms outcome(s) of a participation-focused intervention understand what works, conditions, how. was designed realist evaluation. Participant recruitment occurred through purposive theoretical sampling parents participating Local Environment Model at Beitostolen...
Purpose: Investigate the combination effects of strength training and Botulinum Toxin Type-A (BoNT-A) on muscle morphology in children with Cerebral Palsy (CP). Methods: Fifteen receiving BoNT-A, classified as Spastic Diplegic CP, GMFCS I-II, aged 5–12 years were recruited for this study. Randomly allocated to 10 weeks either before or after assessed over 6 months. Eight 15 also completed a control period. The Modified Ashworth Scale measured spasticity. Goal Attainment (GAS) achievement...
To investigate the muscle size-strength relationship of knee flexors and extensors in children with spastic cerebral palsy (CP) relation to typically developing (TD).Eighteen Diplegia, Gross Motor Function Classification System I-III (mean 7 y 5 mo SD 1 mo) 19 TD 6 9 participated. Muscle volume (MV) anatomical cross-sectional area (aCSA) were assessed using MRI. Measures peak torque (PT) work isometrically isokinetically a Biodex dynamometer, normalised bodymass (Bm).Children CP weaker than...
ABSTRACT The diarrheal pathogen Clostridium difficile consists of at least six distinct evolutionary lineages. RT017 lineage is anomalous, as strains only express toxin B, compared to from other lineages that produce toxins A and B and, occasionally, binary toxin. Historically, initially was reported in Asia but now has been worldwide. We used whole-genome sequencing phylogenetic analysis investigate the patterns global spread population structure 277 isolates animal human origins...
Tinea imbricata is a chronic dermatophyte infection caused by Trichophyton concentricum affecting large areas of the skin surface. Spontaneous improvement unusual and relapse after apparently successful treatment common. In this study in Papua New Guinea it was found that high proportion infected patients had immediate-type hypersensitivity (52%) or negative responses (46%) to intradermal trichophytin. The majority failed develop delayed-type on testing as assessed vitro leucocyte migration...
Aim To determine the neuromuscular outcomes of an eccentric strength‐training programme for children and adolescents with cerebral palsy (CP). Method In this randomised, parallel‐group trial waiting control, 14 participants CP (six males, eight females; mean age 11y, SD 2y range 9–15y), diagnosed upper‐limb spasticity were compared age‐ sex‐matched typically developing participants. Participants completed a 6‐week progressive resistance‐strengthening programme, performing lengthening...
Evidence-based recommendations regarding which exercise tests to use in children and adolescents with cerebral palsy (CP) are lacking. This makes it very difficult for therapists researchers choose the appropriate exercise-related outcome measures this group. study aimed identify a core set of CP.Fifteen experts (10 physical therapists/researchers five physiologists; three from Netherlands, two USA, one UK, Canada, four Australia) participated Delphi survey took stages achieve consensus....
Purpose: To measure activity, participation and QoL in children with CP to determine how these differ from a comparable group of typically developing (TD) children.Method: A total eleven males eight females ranging age 5 12 years (mean 7 10 months, SD 1 year months; GMFCS level I–II) 19 sex matched TD peers were recruited. Activity was measured using Paediatric Card Sort (PACS), 6-Minute Walk Test Timed Up Go (TUG). Participation the assessment Life Habits (LIFE-H) quality life Cerebral...
In this study we aimed to characterize muscle composition of the medial gastrocnemius in children with spastic cerebral palsy (SCP) using quantitative ultrasound.Forty SCP, aged 4-14 years, participated study. Children were grouped according gross motor function classification system (GMFCS I-V) and compared a cohort age- gender-matched, typically developing (TD; n = 12). Ultrasound scans taken gastrocnemius. Images then characterized grayscale statistics determine mean echo intensity (EI)...
This study aimed to track alterations in muscle volume for 6 months children with cerebral palsy (CP) after the first exposure botulinum neurotoxin A (BoNT-A), a commonly used focal spasticity treatment.Eleven ambulant (eight males, three females) spastic CP, mean age 8 years 10 (SD 3y 1mo) participated. Participants received injections affected gastrocnemius. The of gastrocnemius, soleus, tibialis anterior, and hamstrings was measured using magnetic resonance imaging. Muscle normalized bone...
The purpose of this study was to establish the nature and stability strength-size relationship for knee flexors extensors across a 6-month period childhood growth.Nineteen typically developing children aged 5-11 years underwent lower limb magnetic resonance imaging (MRI) dynamometry strength assessments on 2 occasions, 6 months apart. Muscle volume (MV) maximum anatomical cross-sectional area (aCSA) were determined using MRI analysis software. Isokinetic corresponding isometric isokinetic...
Botulinum toxin A (BoNTA) is routine treatment for hypertonicity in children with cerebral palsy (CP).This single-blind, prospective, cross-sectional study of 10 participants (mean age 11 years 7 months) was done to determine the relationship between muscle histopathology and BoNTA treated medial gastrocnemius CP. Open biopsies were taken from vastus lateralis (control) during orthopedic surgery.Neurogenic atrophy seen 6 4 months 3 post-BoNTA. Type 1 fiber loss type 2 predominance...
Abstract Background and objectives Developmental coordination disorder (DCD) is a prevalent childhood movement disorder, impacting the ability to perform skills at an age appropriate level. Although differences in grey matter (GM) volumes have been found related developmental disorders, no such evidence has linked with DCD date. This cross‐sectional study assessed structural brain children without DCD. Methods High‐resolution images were acquired from 44 aged 7.8–12 years, including 22...