A5042192410- Diabetes and associated disorders
- Diabetes Management and Research
- Growth Hormone and Insulin-like Growth Factors
- Pancreatic function and diabetes
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Child Nutrition and Water Access
- Hip disorders and treatments
- Cerebral Palsy and Movement Disorders
- Genetics and Neurodevelopmental Disorders
- Adipose Tissue and Metabolism
- Pituitary Gland Disorders and Treatments
- Economic and Financial Impacts of Cancer
- Male Breast Health Studies
- Pain Mechanisms and Treatments
- Scoliosis diagnosis and treatment
- Testicular diseases and treatments
- Childhood Cancer Survivors' Quality of Life
- Metabolism, Diabetes, and Cancer
- Genomic variations and chromosomal abnormalities
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and disorders
- Thyroid Disorders and Treatments
- Kruppel-like factors research
Children's Hospital Central California
2021
Medical College of Wisconsin
2006-2020
Children's Hospital of Wisconsin
2009-2020
Al Baha University
2016-2017
Shendi University
2016
Faculty of Public Health
2016
University of California, Los Angeles
2006-2007
Mattel Children's Hospital
2003
Dhahran Health Center
1996
Children's Hospital of Pittsburgh
1993
Type 2 diabetes (T2D) is the result of interaction between environmental factors and a strong hereditary component.We review heritability T2D as well history genetic genomic research in this area.Very few risk genes were identified using candidate gene linkage-based studies, but advent genome-wide association studies has led to identification multiple genes, including several that not previously known play any role T2D.Highly replicated for example TCF7L2, KCNQ1 KCNJ11, are discussed greater...
Epigenetic mechanisms, including DNA methylation, mediate the interaction between gene and environment may play an important role in obesity epidemic. We assessed relationship methylation peripheral blood mononuclear cells (PBMCs) at 485,000 CpG sites across genome family members (8-90 y of age) using a discovery cohort (192 individuals) validation (1,052 Northern European ancestry. After Bonferroni-correction (Pα=0.05 = 1.31 × 10−7) for genome-wide significance, we identified 3 loci,...
Fatty acid-binding proteins (FABPs) play regulatory roles at the nexus of lipid metabolism and signaling. Dyslipidemia in clinical manifestation frequently co-occurs with obesity, insulin resistance hypertension Metabolic Syndrome (MetS). Animal studies have suggested FABPs expressing MetS phenotypes. In our family cohort Northern European descent, transcript levels peripheral white blood cells (PWBCs) a key FABPs, FABP3, is correlated leading components. However, evidence supporting...
Cerebral palsy is associated with osteopenia, increased fracture risk, short stature, and decreased muscle mass, whereas GH therapy bone mineral density (BMD) linear growth improvement in body composition.We conducted a pilot study to evaluate the effect of 18 months on spinal BMD, growth, biochemical markers, functional measures children cerebral palsy.The was randomized control trial, from 2002-2005 at University California, Los Angeles, Orthopedic Hospital's Center for Palsy.Patients...
The prevalence of chronic diseases such as cancer, type 2 diabetes, metabolic syndrome (MetS), and cardiovascular disease increases with age in all populations. Epigenetic features are hypothesized to play important roles the pathophysiology age-associated diseases, but a map these markers is lacking. We searched for genome-wide methylation signatures peripheral blood individuals at high risks MetS by profiling 485,000 CpG sites 192 Northern European ancestry using Illumina HM450 array....
Metabolic syndrome (MetS) is an aberration associated with increased risk for cancer and inflammation. Adiponectin, adipocyte-produced abundant protein hormone, has countering effect on the diabetogenic atherogenic components of MetS. Plasma levels adiponectin are negatively correlated onset patient mortality. We previously performed microsatellite linkage analyses using as a surrogate marker revealed two QTLs chr5 (5p14) chr14 (14q13). Using individuals from 85 extended families that...
Continuous subcutaneous insulin infusion (CSII) is a safe and effective alternative to injections in pediatric type 1 diabetes mellitus. CSII can be associated with an increased risk of hypoglycemia diabetic ketoacidosis (DKA) some patients. In our Center, patients/guardians are screened for proficiency management skills as prerequisite initiation CSII. We reviewed the clinical data from patients assess predictors nonadherence therapy.We retrospectively collected on all initiations between...
Metabolic Syndrome (MetS) is a phenotype cluster predisposing to type 2 diabetes and cardiovascular disease. We conducted study elucidate the genetic basis underlying linkage signals for multiple representative traits of MetS that we had previously identified at two significant QTLs on chromosomes 3q27 17p12.We performed QTL-specific genomic transcriptomic analyses in 1,137 individuals from 85 extended families contributed original linkage. tested SOLAR association phenotypes with...
<i>Background/Aims:</i> Childhood cerebral palsy (CP) is associated with osteopenia and the GH-IGF axis plays an important role in bone metabolism. We studied relationship between spinal mineral density (BMD) serum IGF-1 IGFBP-3 children CP. <i>Methods:</i> Cross-sectional study of 30 (9 F 21 M, ages 4.5–15) Subjects underwent dual-energy x-ray absorptiometry scans (spinal BMD), blood tests (IGF-1, IGFBP-3, Ca, P, PTH, vitamin D, osteocalcin) urine (N-telopeptide)....
Factors such as gender, ethnicity, and age affect pain processing in children adolescents with chronic pain. Although obesity has been shown to adults, almost nothing is known about pediatric populations. The aim of this pilot study was explore whether alters sensory Participants were recruited from a clinic (Chronic Pain (CP), n = 12 normal weight; Chronic + Obesity (CPO), 19 overweight/obesity) an (Obesity alone (O), 14). quantitative testing protocol included assessments thermal...
Diarrheal diseases are a collection of caused by multiple viral, bacterial, and parasitic organisms that share common symptoms, it’s defined as the passage three or more loose liquid stool per day. This Descriptive community based cross sectional study was conducted in Shendi Town during year2015To Knowledge Attitude towards diarrheal disease children under five years. A system simple random sampling allocation followed to select sample for coverage diarrhea town. The data collected through...