A5018068490- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Congenital Heart Disease Studies
- Cardiac Arrest and Resuscitation
- Birth, Development, and Health
- Pulmonary Hypertension Research and Treatments
- Nitric Oxide and Endothelin Effects
- Neonatal Health and Biochemistry
- Adipose Tissue and Metabolism
- Infant Nutrition and Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Mechanical Circulatory Support Devices
- Anesthesia and Neurotoxicity Research
- Cardiovascular Function and Risk Factors
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Impact on Reproduction
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pancreatic function and diabetes
- IoT-based Smart Home Systems
- Adenosine and Purinergic Signaling
- Breastfeeding Practices and Influences
Apollo Hospitals
2022-2024
Florida College
2023
University of Florida
2023
University at Buffalo, State University of New York
2011-2023
Koneru Lakshmaiah Education Foundation
2022-2023
Women & Children's Hospital of Buffalo
2009-2023
New York University
2019-2020
University of Rochester
2019
The Ohio State University
2016
Manipal University College Malaysia
2016
Failed alveolar formation and excess, disordered elastin are key features of neonatal chronic lung disease (CLD). We previously found fewer alveoli more in lungs preterm compared with term lambs that had mechanical ventilation (MV) O(2)-rich gas for 3 wk (MV-3 wk). hypothesized that, than lambs, MV-3 would reduce expression growth factors regulate alveolarization (VEGF, PDGF-A) increase [transforming factor (TGF)-alpha, TGF-beta(1)] matrix molecules (tropoelastin, fibrillin-1, fibulin-5,...
<b>Background</b> Inhaled nitric oxide (iNO) is being increasingly used in preterm infants < 34 weeks with hypoxemic respiratory failure (HRF) and/or pulmonary hypertension (PH). <b>Objective</b> To evaluate the risk factors, survival characteristics, and lung histopathology PH/HRF. <b>Methods</b> Retrospective chart review was conducted to determine characteristics of 93 treated iNO first 28 days compared 930 matched controls. Factors associated HRF smooth muscle actin from nine autopsies...
Prostacyclin is a pulmonary vasodilator and produced by prostacyclin synthase stimulates adenylate cyclase (AC) via the receptor (IP) to produce cAMP. Forskolin direct stimulant of AC. Phosphodiesterase 3 hydrolyzes cAMP inhibited milrinone. Objective: To characterize prostacyclin-AC-cAMP pathway in ovine ductal ligation model persistent hypertension newborn (PPHN). Setting: University-based laboratory animal facility. Subjects: Lambs delivered time-dated pregnant ewes. Interventions: Fifth...
Background Supplemental O2 to treat bronchopulmonary dysplasia (BPD) in premature infants, is a major risk factor producing alteration lung function, airway reactivity, and predisposition respiratory infections. This study explores inflammatory responses following neonatal hyperoxia adult mice. Methods Newborn mouse litters were randomized 85% or room air (RA) on P3 for 12 days; mice sacrificed either P15 at 15 weeks recovery RA. Airway hyper reactivity (AHR) was assessed vivo (8 weeks)...
Caffeine therapy for apnea of prematurity reduces the incidence bronchopulmonary dysplasia (BPD) in premature neonates. Several mechanisms, including improvement pulmonary mechanics underly beneficial effects caffeine BPD. As vascular development promotes alveologenesis, we hypothesized that might enhance angiogenesis lung, promoting lung growth, thereby attenuating BPD.C57Bl/6 mice litters were randomized within 12 h birth to room air (RA) or 95%O2 receive (20 mg/kg/day) placebo 4 days and...
BACKGROUND:Premature birth disrupts hypoxia driven microvascular development that directs alveolar and lung growth. Changes in oxygen exposure after can perturb the regulation of angiogenesis leading to bronchopulmonary dysplasia (BPD). We studied effects intermittent or hypero xia on HIF angiogenic gene expression newborn mice. METHODS:Newborn litters were randomized within 12 h 12% O2 (4 h), 50% h) (2 h)/50% followed by room air (RA) recovery for 20 h. Mice RA control group. The mice...
The outcomes of premature infants have improved greatly; however, the health risks in adulthood are still relatively unclear. Bronchopulmonary dysplasia (BPD) is a major risk factor for alteration lung function and predisposition to respiratory morbidity, associated with hyperoxia. study explores effect neonatal hyperoxia on organ systems adult mice. Newborn mouse litters were randomized 85%O2 or room air (RA) P3 12 days; mice sacrificed at P3, P7, P15, 3 months 9 months. Lungs assessed by...