A5036515738- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- Respiratory viral infections research
- Organ Transplantation Techniques and Outcomes
- Tracheal and airway disorders
- Nutrition and Health in Aging
- Mechanical Circulatory Support Devices
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- Frailty in Older Adults
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Telomeres, Telomerase, and Senescence
- Pulmonary Hypertension Research and Treatments
- Mycobacterium research and diagnosis
- Cystic Fibrosis Research Advances
- Medical Imaging and Pathology Studies
- Complement system in diseases
- Systemic Sclerosis and Related Diseases
- COVID-19 Clinical Research Studies
- Galectins and Cancer Biology
University of California, San Francisco
2016-2025
San Francisco VA Medical Center
2016-2025
San Francisco VA Health Care System
2018-2025
International Society for Heart and Lung Transplantation
2024
IFC Research (United Kingdom)
2024
United States University
2023
University of California System
2014-2022
Veterans Health Administration
2022
Advanced ENT and Allergy
2020-2021
Beth Israel Deaconess Medical Center
2005-2009
Neutralizing autoantibodies against type I interferons (IFNs) have been found in some patients with critical coronavirus disease 2019 (COVID-19), the caused by severe acute respiratory syndrome 2 (SARS-CoV-2). However, prevalence of these antibodies, their longitudinal dynamics across severity scale, and functional effects on circulating leukocytes remain unknown. Here, 284 COVID-19, we IFN–specific peripheral blood samples from 19% 6% disease. We no IFN individuals moderate Longitudinal...
Frailty is associated with morbidity and mortality in abdominal organ transplantation but has not been examined lung transplantation.To examine the construct predictive validity of frailty phenotypes transplant candidates.In a multicenter prospective cohort, we measured Fried Phenotype (FFP) Short Physical Performance Battery (SPPB). We evaluated through comparisons conceptually related factors. In nested case-control study frail nonfrail subjects, serum IL-6, tumor necrosis factor receptor...
Frailty is associated with increased mortality among lung transplant candidates. We sought to determine the association between frailty, as measured by Short Physical Performance Battery (SPPB), and after transplantation. In a multicenter prospective cohort study of adults who underwent transplantation, preoperative frailty was assessed SPPB (n = 318) and, in secondary analysis, Fried Phenotype (FFP; n 299). tested following transplantation propensity score-adjusted Cox models. calculated...
Under the U.S. Lung Allocation Score (LAS) system, older and sicker patients are prioritized for lung transplantation (LT). The impact of these changes on health-related quality life (HRQL) after transplant has not been determined. In a single-center prospective cohort study from 2010 to 2016, we assessed HRQL before repeatedly LT up 3 years using SF12-Physical Mental Health, respiratory-specific Airway Questionnaire 20-Revised, Euroqol 5D/Visual Analog Scale utility measures by multivariate...
Platelets have a wide range of functions including critical roles in hemostasis, thrombosis, and immunity. We hypothesized that during acute inflammation, such as life-threatening sepsis, there are fundamental changes the sites platelet production phenotypes resultant platelets. Here, we showed sepsis spleen was major site megakaryopoiesis production. Sepsis provoked an adrenergic-dependent mobilization megakaryocyte-erythrocyte progenitors (MEPs) from bone marrow to spleen, where IL-3...
Promoting immune tolerance to transplanted organs can minimize the amount of immunosuppressive drugs that patients need take, reducing lifetime risks mortality and morbidity. Regulatory T cells (T regs ) are essential for tolerance, preclinical studies have shown their therapeutic efficacy in inducing transplantation tolerance. Here, we report results a phase 1/2 trial (ARTEMIS, NCT02474199) autologous donor alloantigen–reactive reg (darT therapy individuals 2 6 years after receiving living...
Frailty is prevalent in lung transplant candidates (LTC) and associated with waitlist delisting or death. We performed a pilot study to assess the safety feasibility of home-based, mobile health technology-facilitated intervention treat frailty LTC.We an 8-week, nonrandomized, home-based exercise nutrition LTC Short Physical Performance Battery (SPPB) scores ≤11. The utilized customized, device application ("app") enabling monitoring progression real time. aimed evaluate key process...
Human adaptive-like natural killer (NK) cells express low levels of FcεRIγ (FcRγ−/low) and are reported to accumulate during COVID-19 infection; however, the mechanism underlying regulating FcRγ expression in NK has yet be fully defined. We observed lower protein cell subsets from lung transplant patients rapamycin treatment, suggesting a link with reduced mTOR activity. Further, FcRγ−/low healthy donors displayed discovered that upregulation is dependent on proliferation progression...
Acute lung allograft dysfunction (ALAD) is an imprecise syndrome denoting concern for the onset of chronic (CLAD). Mechanistic biomarkers are needed that stratify risk ALAD progression to CLAD. We hypothesized single cell investigation bronchoalveolar lavage (BAL) cells at time would identify immune linked progressive graft dysfunction.
Pulmonary ischemia-reperfusion injury (IRI) is a clinical syndrome of acute lung that occurs after transplantation or remote organ ischemia. IRI causes early mortality and has no effective therapies. While NK cells are innate lymphocytes capable recognizing injured cells, their roles in incompletely understood. Here, we demonstrated were increased frequency cytotoxicity 2 different mouse models. We showed trafficked to the tissue from peripheral reservoirs more mature within tissue. Acute...
Antibodies targeting human leukocyte antigen (HLA)/major histocompatibility complex (MHC) proteins limit successful transplantation and transfusion, their presence in blood products can cause lethal transfusion-related acute lung injury (TRALI). It is unclear which cell types are bound by these anti-leukocyte antibodies to initiate an immunologic cascade resulting injury. We therefore conditionally removed MHC class I (MHC I) from likely cellular targets antibody-mediated Only the removal of...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a global economic and health crisis. Recently, plasma levels of galectin-9 (Gal-9), β-galactoside-binding lectin involved in immune regulation viral immunopathogenesis, were reported to be elevated the setting COVID-19 disease. However, impact Gal-9 on SARS-CoV-2 infection immunopathology remained elucidated. In this study, we demonstrate that treatment potently enhances replication human airway epithelial...
Supplementary methods to identify acute rejection and distinguish from infection may improve clinical outcomes for lung allograft recipients. We hypothesized that distinct bronchoalveolar lavage (BAL) cell profiles are associated with infection. retrospectively compared 2939 BAL counts immunophenotypes against concomitantly obtained transbronchial biopsies microbiologic studies. randomly assigned 317 subjects a derivation or validation cohort. samples were classified into four groups:...
Lung transplantation offers great promise for otherwise terminal lung diseases, but the development of bronchiolitis obliterans syndrome (BOS) continues to limit survival. Although acute rejection and lymphocytic have been identified as risk factors BOS, it is unclear whether large-airway inflammation conveys same risk.We evaluated bronchitis on endobronchial biopsies a factor BOS mortality.Endobronchial were collected graded during surveillance after transplantation. We assessed samples...