A5056803597- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Metalloenzymes and iron-sulfur proteins
- Kawasaki Disease and Coronary Complications
- Wound Healing and Treatments
- Cancer, Lipids, and Metabolism
- Inflammasome and immune disorders
- Viral Infections and Immunology Research
- Platelet Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Histone Deacetylase Inhibitors Research
- Renal and related cancers
- RNA modifications and cancer
- Genetics, Aging, and Longevity in Model Organisms
- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
- Heat shock proteins research
- Genetic Syndromes and Imprinting
- Polyamine Metabolism and Applications
- Prostate Cancer Treatment and Research
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Peptidase Inhibition and Analysis
- Prostate Cancer Diagnosis and Treatment
Brigham and Women's Hospital
2018-2023
Harvard University
2018-2023
Centre National de la Recherche Scientifique
2013-2017
Inserm
2013-2017
Genetique Reproduction and Developpement
2014-2016
Université Clermont Auvergne
2013-2016
Centre de Recherche en Nutrition Humaine d'Auvergne
2014
Platelets have a wide range of functions including critical roles in hemostasis, thrombosis, and immunity. We hypothesized that during acute inflammation, such as life-threatening sepsis, there are fundamental changes the sites platelet production phenotypes resultant platelets. Here, we showed sepsis spleen was major site megakaryopoiesis production. Sepsis provoked an adrenergic-dependent mobilization megakaryocyte-erythrocyte progenitors (MEPs) from bone marrow to spleen, where IL-3...
Significance Dynamic demethylation of histone residues plays a crucial role in the regulation gene expression. Lysine Specific Demethylase 1 (LSD1) can remove both transcriptionally permissive and repressive marks. How these activities are controlled is not clearly understood. Here, we show that estrogen-related receptor α (ERRα) induces LSD1 to erase marks vitro. Through such mechanism, ERRα commonly activate set transcriptional targets include genes involved cellular capacity invade...
Multisystem inflammatory syndrome in children (MIS-C) evolves some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID-19 severity and outcomes were previously correlated Notch4 expression on Tregs, here, we show that Tregs MIS-C destabilized through a Notch1-dependent mechanism. Genetic analysis revealed had enrichment of rare deleterious variants affecting inflammation autoimmunity pathways, including dominant-negative mutations...
The chaperone nucleophosmin (NPM1) is over-expressed in the epithelial compartment of prostate tumours compared to adjacent healthy epithelium and may represent one key actors that support neoplastic phenotype adenocarcinoma cells. Yet, mechanisms underlie NPM1 mediated remain elusive prostate. To better understand functions cancer cells, we sought characterize its impact on cells behaviour decipher by which it act. Here show favors tumour cell migration, invasion colony forming....
The mammalian target of rapamycin (mTOR) plays essential roles in the regulation growth-related processes such as protein synthesis, cell sizing and metabolism both normal pathological growing conditions. These functions mTOR are thought to be largely a consequence its cytoplasmic activity regulating translation rate, but accumulating data highlight supplementary role(s) for this serine/threonine kinase within nucleus. Indeed, nuclear activities currently associated with control biosynthetic...
Squamous Cell Carcinoma (SCC) develops in stratified epithelial tissues and demonstrates frequent alterations transcriptional regulators. We sought to discover SCC-specific programs identified the transcription factor Basonuclin 1 (BNC1) as highly expressed SCC compared other tumor types. RNA-seq ChIP-seq analysis pro-proliferative genes activated by BNC1 cells keratinocytes. Inhibition of suppressed proliferation increased migration via FRA1. In contrast, reduction keratinocytes caused...
Abstract Multisystem inflammatory syndrome in children (MIS-C) evolves some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID-19 severity and outcome were previously correlated Notch4 expression on regulatory T (Treg) cells, here we show that the Treg cells MIS-C are destabilized association increased Notch1 expression. Genetic analysis revealed enriched rare deleterious variant impacting inflammation autoimmunity pathways,...
Abstract Nucleophosmin NPM1 is a molecular chaperone involved in many aspect of cellular physiology, eg. ribosomal biogenesis and cell cycle regulation. overexpressed numerous types solid tumors, including prostate cancer but the underlying mechanisms are largely unknown. Using both lines transgenic mouse models, we show that expression significantly increased cells where PI3K-AKT-mTOR pathway activated through PTEN deletion. This overexpression reversed when treated with pharmacological...