A5101784966- Nanoparticle-Based Drug Delivery
- Zeolite Catalysis and Synthesis
- Mesoporous Materials and Catalysis
- Advanced Cellulose Research Studies
- Lignin and Wood Chemistry
- Catalysis and Oxidation Reactions
- Catalytic Processes in Materials Science
- Nanoplatforms for cancer theranostics
- Traditional Chinese Medicine Studies
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Acute Ischemic Stroke Management
- Metal-Organic Frameworks: Synthesis and Applications
- Graphene and Nanomaterials Applications
- Identification and Quantification in Food
- Cancer-related gene regulation
- Genetic diversity and population structure
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Neonatal Respiratory Health Research
- Clostridium difficile and Clostridium perfringens research
- Advanced Nanomaterials in Catalysis
- Polysaccharides and Plant Cell Walls
- Enzyme-mediated dye degradation
Shandong Academy of Sciences
2019-2024
Qilu University of Technology
2019-2024
First Affiliated Hospital of Zhengzhou University
2018-2024
Henan Provincial Center for Disease Control and Prevention
2023-2024
First Affiliated Hospital of Henan University of Science and Technology
2014-2024
Center for High Pressure Science and Technology Advanced Research
2024
Tianjin University of Science and Technology
2023
Zhengzhou University
2009-2023
Sichuan University
2023
Lanzhou University
2023
Abstract Background Bacterial infection in wounds has become a major threat to human life and health. With the growth use of synthetic antibiotics elevated evolution drug resistant bacteria body cells requires development novel wound curing strategies. Herein, pH-responsive hydrogel (RPC/PB) was fabricated using poly(vinyl alcohol)-borax (PB) natural antibiotic resveratrol grafted cellulose nanofibrils (RPC) for bacterial-infected management. Results In this matrix, RPC conjugate...
In this work, we designed a novel multifunctional Pickering emulsion stabilized by lignin-based nanoparticles. We utilized the industrial waste lignin to prepare thermoresponsive copolymer grafting poly(N-isopropylacrylamide) (PNIPAM) onto via atom transfer radical polymerization (ATRP) and then formed self-assembled nanoparticles (AL-g-PNIPAM NPs). AL-g-PNIPAM NPs well trans-resveratrol (trans-RSV)-containing palm oil droplets in water. Thanks abundant UV chromophoric groups of lignin,...
The electron-rich characteristic and low work function endow electrides with excellent performance in (opto)electronics catalytic applications; these two features are closely related to the structural topology, constituents, valence electron concentration of electrides. However, synthesized electrides, especially two-dimensional (2D) limited specific prototypes anionic
Abstract Poor delivery of insoluble anticancer drugs has so far precluded their clinical application. In this study, an efficient tumor targeted-nanoparticle system, transferrin-eight-arm-polyethylene glycol–dihydroartemisinin nanoparticles (TF-8arm-PEG-DHA NPs) for the vehiculation dihydroartemisinin (DHA) was first prepared and evaluated its targeting efficiency cytotoxicity in vitro vivo to Lewis lung carcinoma (LLC) cells, which overexpress transferrin receptors (TFRs). The synthesized...
Ginsenoside Rb1 is shown to self-assemble with anticancer drugs form stable nanoparticles, which have greater effects<italic>in vitro</italic>and<italic>in vivo</italic>than the free drugs.
In this study, a targeted nanoparticle platform for co-delivery of anticancer drugs based on folate-conjugated eight-arm-polyethylene glycol-betulinic acid (F-8arm-PEG-BA) was first presented. F-8arm-PEG-BA synthesized by introducing target molecules (folate) and drug (betulinic acid, BA) to hydrophilic (8arm-PEG). Then another drug, hydroxycamptothecin (HCPT), encapsulated into the self-assembled nanoparticles from conjugate simple nanoprecipitation method. These F-8arm-PEG-BA/HCPT (NPs)...
Abstract Protein disulfide isomerase (PDI) involves cell survival and death. Whether PDI mediates mechanical stretch stress (SS) and/or advanced glycosylation end products (AGEs) -triggered simultaneous increases in proliferation apoptosis of vascular smooth muscle cells (VSMCs) is unknown. Here, we hypothesized that different expression levels trigger completely opposite fates among the VSMC subtypes. Mouse veins were grafted into carotid arteries non-diabetic diabetic mice for 8 weeks;...
Single-drug therapy for cancer is greatly hampered by its non-specific delivery to the target tissue, limited efficacies, poor tolerability, and resistance profiles. In order overcome these limitations, we developed a new targeted nanoparticle platform co-delivery of two different anticancer drugs. A conjugate based on carboxymethylcellulose (CMC) was first synthesized introducing hydrophilic molecules (PEG), (folate), drug (betulinic acid) into CMC. Then another hydroxycamptothecine (HCPT)...
The clinical applications of natural anticancer drugs are being restricted by poor water solubility, fast clearance in the circulation, lack targeting to tumor cells, and tissue penetration. To address these problems, this study, we developed a novel lignin-based targeted polymeric nanoparticles (NPs) platform, folic acid-polyethylene glycol-alkaline lignin conjugates (FA-PEG-AL), via self-assembly for delivery drug (hydroxyl camptothecin, HCPT). These had moderate particle size (∼150 nm)...
Abstract Aberrant proliferation and migration of vascular smooth muscle cells (VSMCs) contribute significantly to the development many human cardiovascular diseases, including hypertension. The present study aimed evaluate in vitro functional roles long noncoding RNA growth arrest‐specific transcript 5 (GAS5) VSMCs explored underlying molecular mechanisms. We found that GAS5 was downregulated PDGF‐bb‐treated VSMCs, overexpression remarkably attenuated PDGF‐bb‐induced VSMC migration. In...
Development of biocompatible and biodegradable nanocarriers with multiple functionalities has attracted great interest in recent years.
Aims This study was designed to demonstrate simultaneous increases in proliferation and apoptosis of vascular smooth muscle cells (VSMCs) leading accelerated vein graft remodeling explore the underlying mechanisms. Methods Vein grafts were performed non-diabetic diabetic mice. The cultured quiescent VSMCs subjected mechanical stretch stress (SS) and/or advanced glycosylation end products (AGEs). Harvested treated used detect cell proliferation, apoptosis, mitogen-activated protein kinases...