A5022927618- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Fungal and yeast genetics research
- MRI in cancer diagnosis
- Medical Image Segmentation Techniques
- Advanced Vision and Imaging
- Plant Pathogens and Fungal Diseases
- Image Retrieval and Classification Techniques
- Probiotics and Fermented Foods
- Yeasts and Rust Fungi Studies
- Medical Imaging and Analysis
- Robotics and Sensor-Based Localization
- Pneumocystis jirovecii pneumonia detection and treatment
- Parasitic Diseases Research and Treatment
- Fungal Biology and Applications
- Advanced Image and Video Retrieval Techniques
- Nematode management and characterization studies
- Antimicrobial Resistance in Staphylococcus
- Face and Expression Recognition
- AI in cancer detection
- Infectious Diseases and Mycology
- Image and Object Detection Techniques
- Peptidase Inhibition and Analysis
State Key Laboratory of Genetic Engineering
2019-2025
Huashan Hospital
2019-2025
Fudan University
2019-2025
Shanghai Micro Satellite Engineering Center
2023-2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai Pulmonary Hospital
2024
Tongji University
2024
Tencent (China)
2023
KLA (United States)
2022
In this paper, we present a unified framework for the rigid and nonrigid point set registration problem in presence of significant amounts noise outliers. The key idea is to represent input sets using Gaussian mixture models. Then, reformulated as aligning two mixtures such that statistical discrepancy measure between corresponding minimized. We show popular iterative closest (ICP) method several existing methods field are closely related can be reinterpreted meaningfully our general...
Candida auris is an emerging multidrug-resistant fungal pathogen and a new global threat to human health. A unique morphological feature of this fungus its multicellular aggregating phenotype, which has been thought be associated with defects in cell division. In study, we report form two clinical C . isolates increased biofilm forming capacity due enhanced adherence adjacent cells surfaces. Unlike the previously reported morphology, can become unicellular after treatment proteinase K or...
Abstract Candida auris has become a serious threat to public health. The mechanisms of how this fungal pathogen adapts the mammalian host are poorly understood. Here we report rapid evolution an adaptive C. multicellular aggregative morphology in murine during systemic infection. cells accumulate brain and exhibit obvious advantages over single-celled yeast-form Genetic mutations, specifically de novo point mutations genes associated with cell division or budding processes, underlie...
The emerging human fungal pathogen Candida auris has become a serious threat to public health. This spread 10 provinces in China as of December 2023. Here we describe 312 C. auris-associated hospitalizations and 4 outbreaks healthcare settings from 2018 Three genetic clades have been identified during this period. Molecular epidemiological analyses indicate that introduced local transmission occurred multiple instances China. Most isolated (98.7%) exhibited resistance fluconazole, while only...
This paper proposes a novel and robust approach to the point set registration problem in presence of large amounts noise outliers. Each sets is represented by mixture Gaussians treated as aligning two mixtures. We derive closed-form expression for L(2) distance between Gaussian mixtures, which turn leads computationally efficient algorithm. new algorithm has an intuitive interpretation, simple implement exhibits inherent statistical robustness. Experimental results indicate that our achieves...
Diffusion magnetic resonance imaging (MRI) is a relatively new modality which capable of measuring the diffusion water molecules in biological systems noninvasively. The measurements from MRI provide unique clues for extracting orientation information brain white matter fibers and can be potentially used to infer connectivity vivo using tractography techniques. tensor (DTI), currently most widely technique, fails extract multiple fiber orientations regions with complex microstructure. In...
The emerging human fungal pathogen Candida auris has been recognized as a multidrug resistant species and is associated with high mortality. This fungus was first described in Japan 2009 reported at least 18 countries on five continents. In this study, we report the isolate of C. from bronchoalveolar lavage fluid (BALF) hospitalized woman China. Interestingly, susceptible to all tested antifungals including amphotericin B, fluconazole, caspofungin. Copper sulfate (CuSO4) also potent...
Morphological plasticity has historically been an indicator of increased virulence among fungal pathogens, allowing rapid adaptation to changing environments. Candida auris identified as emerging multidrug-resistant human pathogen global importance. Since the discovery this species, it thought that C. is incapable filamentous growth. Here, we report filamentation and three distinct cell types in auris: typical yeast, filamentation-competent (FC) cells. These form a novel phenotypic switching...
The human fungal pathogen Candida tropicalis is widely distributed in clinical and natural environments. It known to be an obligate diploid organism with incomplete atypical sexual cycle. Azole-resistant C. isolates have been observed increasing prevalence many countries recent years. Here, we report that tebuconazole (TBZ), a triazole fungicide used agriculture, can induce ploidy plasticity the formation of haploid cells . evolved strains variations exhibit cross-resistance between TBZ...
Candida auris is a newly emerging fungal pathogen of humans and has attracted considerable attention from both the clinical basic research communities. Clinical isolates C. are often resistant to one or more antifungal agents. To explore how resistance develops, we performed experimental evolution assays using fluconazole-susceptible isolate (BJCA001). After series passages through medium containing increasing concentrations fluconazole, cells acquired resistance. By sequencing comparing...
The conserved cAMP-dependent protein kinase (PKA) plays critical roles in the regulation of morphological transitions and virulence human fungal pathogen Candida albicans. It has long been thought that PKA catalytic subunit is essential for cell viability this fungus. Paradoxically, single adenylyl cyclase-encoding gene, CYR1, which required production cAMP C. albicans, not growth. Here, a double mutant TPK1 TPK2 (tpk2/tpk2 tpk1/tpk1, t2t1), encode two isoforms was successfully generated,...
Many advanced motion control strategies developed in robotics use captured human data as valuable source of examples to simplify the process programming or learning complex robot motions. Direct and online robots from observed has several inherent challenges. The most important may be representation large number mechanical degrees freedom involved execution movement tasks. Attempting map all such a humanoid is formidable task an instrumentation sensing point view. More importantly, approach...
Candida auris is an emerging pathogenic fungal species found worldwide. Since April 2016, C. colonization/infection cases have been in a general hospital Shenyang, China. The genome-based phylogenetic studies of these isolates remain undefined. In the current study, microbiological characteristics and antifungal susceptibility isolates, which were collected Shenyang during three-year period (2016–2018), investigated. Whole-genome sequencing was applied to investigate genetic variation...
Transferring motion from a human demonstrator to humanoid robot is an important step toward developing robots that are easily programmable and can replicate or learn observed motion. The so called retargeting problem has been well studied several off-line solutions exist based on optimization approaches rely pre-recorded data collected marker-based capture system. From the perspective of interaction, there growing interest in online transfer, particularly without using markers. Such...
A striking feature of pathogenic Candida species is morphological plasticity that facilitates environmental adaptation and host infection. auris an emerging multidrug-resistant fungal pathogen first described in Japan 2009. In this study, we demonstrate clinical isolates C. have multiple colony cellular morphologies including the yeast, filamentous, aggregated, elongated forms. This phenotypic diversity has been observed eight representing four major genetic clades, suggesting it could be a...
Candida vulturna belongs to the haemulonii species complex and is phylogenetically related C. auris. We report a outbreak among persons in Shanxi Province, China, during 2019-2022. Isolates were resistant multiple antifungal drugs exhibited enhanced adhesion biofilm formation properties.
The multidrug-resistant fungal pathogen Candida auris poses an increasing global health threat due to its high transmissibility and persistence in healthcare environments. We aimed explore the potential cases of mixed C. auris-strain colonizations or infections China investigate genetic biological diversity associated isolates. isolates from 5 colonization infection were distinguished by colony morphology verified D1/D2-ITS alignment. Phylogenetic genomic analysis all conducted using whole...