A5074261400- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- NF-κB Signaling Pathways
- Epigenetics and DNA Methylation
- HER2/EGFR in Cancer Research
- Oral microbiology and periodontitis research
- Fungal and yeast genetics research
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Colorectal Cancer Treatments and Studies
- Electronic and Structural Properties of Oxides
- Biochemical and Molecular Research
- Cancer Immunotherapy and Biomarkers
- Supercapacitor Materials and Fabrication
- Gas Sensing Nanomaterials and Sensors
- Cutaneous lymphoproliferative disorders research
- TiO2 Photocatalysis and Solar Cells
- Endoplasmic Reticulum Stress and Disease
- Chronic Lymphocytic Leukemia Research
- Infectious Diseases and Mycology
- Cystic Fibrosis Research Advances
Fudan University
2021-2025
Huashan Hospital
2022-2025
State Key Laboratory of Genetic Engineering
2023-2025
Shenzhen University Health Science Center
2017-2024
Shanghai Jiao Tong University
2021-2024
Shenzhen University
2021-2022
Lanzhou University of Technology
2017-2018
Developing a facile and cost-efficient method to synthesize carbon-based nanomaterials possessing excellent structural functional properties has become one of the most attractive topics in energy conversion storage fields. In this study, density theory calculation results reveal origin high oxygen reduction reaction (ORR) activity predominantly derived from synergistic effect intrinsic defects heteroatom dopants (e.g., N, S) that modulate bandgap charge distribution carbon matrix. Under...
The human fungal pathogen Candida tropicalis is widely distributed in clinical and natural environments. It known to be an obligate diploid organism with incomplete atypical sexual cycle. Azole-resistant C. isolates have been observed increasing prevalence many countries recent years. Here, we report that tebuconazole (TBZ), a triazole fungicide used agriculture, can induce ploidy plasticity the formation of haploid cells . evolved strains variations exhibit cross-resistance between TBZ...
Fungi and bacteria often co-exist physically or chemically interact with each other in their natural niches. This inter-kingdom species interaction is exemplified by the gram-positive bacterial pathogen Streptococcus mutans opportunistic fungal Candida albicans, which human mouth. It has been demonstrated that dynamic between these two plays a critical role virulence biofilm development. In this study, we discovered S. represses filamentous development C. albicans through secreting secondary...
Oncogenic KRAS mutations are a key driver for initiation and progression in non-small cell lung cancer (NSCLC). However, how post-translational modifications (PTMs) of KRAS, especially methylation, modify activity remain largely unclear. Here, we show that SET domain containing histone lysine methyltransferase 7 (SETD7) interacts with methylates at lysines 182 184. SETD7-mediated methylation leads to degradation attenuation the RAS/MEK/ERK signaling cascade, endowing SETD7 potent...
Epidermal growth factor receptor inhibitors (EGFRis) are used to treat many cancers, but their use is complicated by the development of a skin rash that may be severe, limiting and adversely affecting patient quality life. Most studies EGFRi-induced have focused on fully developed stage this disorder, early pathological changes remain unclear. We analyzed high-throughput transcriptome sequencing samples from rats exposed EGFRi afatinib identified keratinocyte activation an alteration in...
Filamentous cell growth is a vital property of fungal pathogens. The mechanisms filamentation in the emerging multidrug-resistant pathogen Candida auris are poorly understood. Here, we show that exposure C . to glycerol triggers rod-like filamentation-competent (RL-FC) phenotype, which forms elongated filamentous cells after prolonged culture period. Whole-genome sequencing analysis reveals all RL-FC isolates harbor mutation 2 H zinc finger transcription factor-encoding gene GFC1 (Gfc1...
Phenotypic plasticity is a common strategy adopted by fungal pathogens to adapt diverse host environments. Candida haemulonii an emerging multidrug-resistant human pathogen that closely related auris. Until recently, it was assumed C. incapable of phenotypic switching or filamentous growth. In this study, we report the identification three distinct phenotypes in haemulonii: white, pink, and filament. The white pink differ cellular size, colony morphology, coloration on phloxine B-...
Opioids are a potential adjuvant treatment for certain cancers; while they primarily used to relieve chronic pain, these drugs may also affect cancer progression and recurrence. Dezocine is one opioid commonly in China, but its effects on cells unknown. Here, we demonstrated the inhibitory effect of dezocine triple-negative breast (TNBC) cells, determined underlying molecular mechanism. We found that suppressed cell proliferation, migration invasion, induced apoptosis TNBC cells. Xenograft...
Candida albicans is a normal resident of the human oral cavity. It also most common fungal pathogen, causing various diseases, particularly in immunocompromised individuals. Chlorhexidine digluconate (CHG) broad-spectrum antimicrobial agent widely used dental practice and has been recommended to treat candidiasis. However, its action mechanism against pathogen C. remains poorly understood. The aim present study was investigate effect CHG at sub-lethal concentrations albicans. inhibited...
The development and synthesis of novel dye sensitizers are important for improving the power conversion efficiency dye-sensitized solar cells (DSSCs) in terms role photon to electricity energy processes. How different moieties tune electronic structures related properties is fundamental issue designing sensitizers. Here, geometries, structures, excitation properties, free variations electron injection (EI) regeneration (DR) porphyrin SM315, GY50, FA, KS, containing bulky...
Abstract Dezocine, a dual agonist and antagonist of the μ-opioid receptor κ-opioid receptor, is widely used as an analgesic in China. At present, there are few studies on anti-tumor effects dezocine, most which to treat cancer pain. However, it has recently been reported that dezocine can induce apoptosis triple negative breast cells. Dezocine may have some activity, but effect potential mechanism treatment other types remain be fully studied. The purpose present study was investigate human...
Anti-epidermal growth factor receptor (EGFR) therapy–associated cutaneous toxicity is a syndrome characterized by papulopustular rash, local inflammation, folliculitis, and microbial infection, resulting in decrease quality of life dose interruption. However, no effective clinical intervention available for this adverse effect. Here, we report the atrophy dermal white adipose tissue (dWAT), highly plastic with various skin-specific functions, correlates rash occurrence exacerbation murine...
ABSTRACT The human fungal pathogen Candida albicans colonizes and infects various host sites with diverse environmental pH. Adaptation to these pH conditions plays a crucial role in its success as commensal pathogen. conserved Rim101 sensing pathway is responsible for neutral–alkaline responses C. . In this study, we identified novel Rfg1-Bcr1 regulatory that governs acidic regulates filamentation A null mutant library was screened, have Rfg1 Bcr1 key regulators of under conditions. directly...
Abstract Oncogenic KRAS mutations are considered to be a key driver for initiation and progression in non-small-cell lung cancer (NSCLC). However, how post-translational modifications (PTMs) of KRAS, especially methylation, modify activity downstream signals remain largely unclear. Here, we showed that SET domain containing histone lysine methyltransferase 7 (SETD7) interacts with methylates at 182 184. SETD7-mediated methylation led degradation attenuation the RAS/MEK/ERK signaling cascade,...
Abstract Anti-epidermal growth factor receptor (EGFR) therapy–associated cutaneous toxicity is a syndrome characterized by papulopustular rash, local inflammation, folliculitis and microbial infection, resulting in decrease quality of life dose interruption. However, no effective clinical intervention available for this adverse effect. Here, we report the atrophy dermal white adipose tissue (dWAT), highly plastic with various skin-specific functions, correlates rash occurrence exacerbation...
Oncogenic KRAS mutations are considered to be a key driver for initiation and progression in non-small-cell lung cancer (NSCLC). However, how post-translational modifications (PTMs) of KRAS, especially methylation, modify activity downstream signals remain largely unclear. Here, we showed that SET domain containing histone lysine methyltransferase 7 (SETD7) interacts with methylates at 182 184. SETD7-mediated methylation led degradation attenuation the RAS/MEK/ERK signaling cascade, endowing...