A5062361695- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- NMR spectroscopy and applications
- Advanced NMR Techniques and Applications
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Atomic and Subatomic Physics Research
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Bone and Joint Diseases
- Electron Spin Resonance Studies
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Epilepsy research and treatment
- Tensor decomposition and applications
- Neuroscience and Neural Engineering
- Parkinson's Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Spinal Cord Injury Research
- Cerebrospinal fluid and hydrocephalus
- Fractional Differential Equations Solutions
- Amyotrophic Lateral Sclerosis Research
- Neurogenesis and neuroplasticity mechanisms
University of Florida
2016-2025
Florida College
1991-2023
National High Magnetic Field Laboratory
2001-2020
Allen Institute for Brain Science
2010-2017
United States Department of Veterans Affairs
1976-2013
Molecular Biology Consortium
2007-2012
WilderShares (United States)
2010
Gainesville Obstetrics & Gynecology
1995
Urbana University
1994
University of Florida Health Science Center
1978-1989
Abstract A new method for mapping diffusivity profiles in tissue is presented. The Bloch‐Torrey equation modified to include a diffusion term with an arbitrary rank Cartesian tensor. This solved give the expression generalized Stejskal‐Tanner formula quantifying diffusive attenuation complicated geometries. makes it possible calculate components of higher‐rank tensors without using computationally‐difficult spherical harmonic transform. General theoretical relations between tensor (DT)...
In this paper, we present a novel constrained variational principle for simultaneous smoothing and estimation of the diffusion tensor field from complex valued diffusion-weighted images (DWI). The involves minimization regularization term L(P) norms, subject to nonlinear inequality constraint on data. data employ is original Stejskal-Tanner equation instead linearized version usually employed in literature. form leads more accurate (when compared version) estimate field. requires that least...
In the recent decades structural connectivity between Broca's area and basal ganglia has been postulated in literature, though no direct evidence of this yet presented. The current study investigates using a novel diffusion-weighted imaging (DWI) fiber tracking method humans vivo. Our findings suggest connections sub-regions anterior one-third putamen, as well ventral nucleus thalamus. Thus, we are first to provide detailed account inferred circuitry involving ganglia, thalamus, area, which...
Purpose In diffusion‐weighted MRI studies of neural tissue, the classical model assumes statistical mechanics Brownian motion and predicts a monoexponential signal decay. However, there have been numerous reports decays that are not monoexponential, particularly in white matter. Theory We modeled diffusion tissue from perspective continuous time random walk. The characteristic decay is represented by Mittag‐Leffler function, which relaxes priori assumptions about governing statistics. then...
Mutations in human ZIP14 have been linked to symptoms of the early onset Parkinsonism and Dystonia. This phenotype is likely related excess manganese accumulation CNS. The metal transporter (SLC39A14) viewed primarily as a zinc that inducible via proinflammatory stimuli. In vitro evidence shows can also transport manganese. To examine role for homeostasis, we used Zip14 knock-out (KO) male female mice conduct comparative metabolic, imaging, functional studies. Manganese was fourfold fivefold...
Abstract This paper details the derivation of rotationally invariant scalar measures from higher‐rank diffusion tensors (DTs) and functions defined on a unit sphere. was accomplished with use an expression that generalizes evaluation trace operator to arbitrary rank, even whose domains are It is shown mean diffusivity selection tensor rank for model used. However, this invariance does not apply anisotropy measures. Therefore, variance‐based, general measure proposed. Also information...
In this paper, we present a new formulation for recovering the fiber tract geometry within voxel from diffusion weighted magnetic resonance imaging (MRI) data, in presence of single or multiple neuronal fibers. To end, define discrete set basis functions. The intravoxel information is recovered at voxels containing crossings bifurcations via use linear combination above mentioned Then, parametric representation mixture Gaussians. Our synthetic experiments depict several advantages by using...
The semi-adiabatic localization by adiabatic selective refocusing (sLASER) sequence provides single-shot full intensity signal with clean and minimal chemical shift displacement error was recommended the international MRS Consensus Group as preferred at high- ultra-high fields. Across-vendor standardization of sLASER 3 tesla has been challenging due to B1 requirements inversion pulses maximum limitations on some platforms. aims this study were design a short-echo that can be executed within...
Abstract Background Clinical trials for upcoming disease‐modifying therapies of spinocerebellar ataxias (SCA), a group rare movement disorders, lack endpoints sensitive to early disease progression, when therapeutics will be most effective. In addition, regulatory agencies emphasize the importance biological outcomes. Objectives READISCA, transatlantic clinical trial readiness consortium, investigated whether advanced multimodal magnetic resonance imaging (MRI) detects pathology progression...
Abstract The apparent diffusion tensor (ADT) imaging method was extended to account for multiple components. A biexponential ADT experiment used obtain separate images of rapidly and slowly diffusing water fractions in excised rat spinal cord. fast slow component tensors were compared found exhibit similar gross features, such as fractional anisotropy, both white gray matter. However, there also some important differences, which are consistent with the different structures occupying...
Spinal cord injury (SCI) induces a progressive pathophysiology affecting cell survival and neurological integrity via complex evolving molecular cascades whose interrelationships are not fully understood. The present experiments were designed to: (1) determine potential functional interactions within transcriptional expression profiles obtained after clinically relevant SCI (2) test the consistency of transcript in two genetically immunologically diverse rat strains characterized by...