A5087867851- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Fungal Biology and Applications
- Fungal and yeast genetics research
- Medical and Biological Ozone Research
- Infectious Diseases and Mycology
- Bacterial Identification and Susceptibility Testing
- Gut microbiota and health
- Herbal Medicine Research Studies
- Antimicrobial Resistance in Staphylococcus
- Pharmacological Effects of Natural Compounds
- Probiotics and Fermented Foods
- Spectroscopy Techniques in Biomedical and Chemical Research
- Peptidase Inhibition and Analysis
- Plant-Microbe Interactions and Immunity
Capital Medical University
2022-2024
Beijing University of Chinese Medicine
2024
Beijing Hospital of Traditional Chinese Medicine
2022-2024
Institute of Microbiology
2015-2020
Chinese Academy of Sciences
2015-2020
University of Chinese Academy of Sciences
2015-2019
State Key Laboratory of Mycology
2018
The emerging human fungal pathogen Candida auris has been recognized as a multidrug resistant species and is associated with high mortality. This fungus was first described in Japan 2009 reported at least 18 countries on five continents. In this study, we report the isolate of C. from bronchoalveolar lavage fluid (BALF) hospitalized woman China. Interestingly, susceptible to all tested antifungals including amphotericin B, fluconazole, caspofungin. Copper sulfate (CuSO4) also potent...
Morphological plasticity has historically been an indicator of increased virulence among fungal pathogens, allowing rapid adaptation to changing environments. Candida auris identified as emerging multidrug-resistant human pathogen global importance. Since the discovery this species, it thought that C. is incapable filamentous growth. Here, we report filamentation and three distinct cell types in auris: typical yeast, filamentation-competent (FC) cells. These form a novel phenotypic switching...
A striking feature of pathogenic Candida species is morphological plasticity that facilitates environmental adaptation and host infection. auris an emerging multidrug-resistant fungal pathogen first described in Japan 2009. In this study, we demonstrate clinical isolates C. have multiple colony cellular morphologies including the yeast, filamentous, aggregated, elongated forms. This phenotypic diversity has been observed eight representing four major genetic clades, suggesting it could be a...
The yeast-filament transition is essential for the virulence of a variety fungi that are pathogenic to humans. N-acetylglucosamine (GlcNAc) potent inducer filamentation in Candida albicans and thermally dimorphic such as Histoplasma capsulatum Blastomyces dermatitidis. However, GlcNAc suppresses rather than promotes tropicalis, fungal species closely related C. albicans. Despite intensive study albicans, regulatory mechanism poorly understood. In this study, we demonstrate cAMP signaling...
While sexual reproduction is pervasive in eukaryotic cells, the strategies employed by fungal species to achieve and complete cycles highly diverse complex. Many fungi, including Saccharomyces cerevisiae Schizosaccharomyces pombe, are homothallic (able mate with their own mitotic descendants) because of switching (HO) endonuclease-mediated mating-type switching. Under laboratory conditions, human pathogen Candida albicans can undergo both heterothallic (opposite- same-sex) mating. However,...
Candida dubliniensis is closely related to albicans, a major causative agent of candidiasis, and primarily associated with oral colonization infection in human immunodeficiency virus (HIV)-positive patients. Despite the high similarity genomic phenotypic features between 2 species, C. much less virulent prevalent than albicans. The ability change morphological phenotypes striking feature species linked virulence. In this study, we report novel phenotype, gray dubliniensis. Together...
Cao Huang Gui Xiang (CHGX) formula, a Chinese herbal medicine, has been empirically used for the treatment of Candida infections. In present study, we discovered that CHGX showed potent antifungal activities against major human fungal pathogen albicans and other clinical species. Besides, indicated had in vivo efficacy on treating C. infection mice without noticeable toxicity at therapeutic concentration. We then set out to investigate mechanisms albicans. found played an important role...
ABSTRACT Candida auris, an emerging fungal pathogen characterized by multidrug resistance and high-mortality nosocomial infections, poses a serious global health threat. However, the precise rapid identification characterization of C. auris remain challenge. Here, we employed Raman spectroscopy combined with machine learning to identify isolates its closely related species as well predict antifungal key virulence factors at single-cell level. The average accuracy among all was 93.33%, 98%...
CaoHuangGuiXiang (CHGX) formula is a traditional Chinese medicine for the treatment of