A5100354170- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Protease and Inhibitor Mechanisms
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Angiogenesis and VEGF in Cancer
- RNA Research and Splicing
- Hepatitis C virus research
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Virus-based gene therapy research
- Colorectal Cancer Surgical Treatments
- Cancer-related Molecular Pathways
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
- Cancer Research and Treatments
- Cell Adhesion Molecules Research
- Healthcare and Venom Research
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bee Products Chemical Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholesterol and Lipid Metabolism
Anhui Medical University
2024
Southeast University
2024
Nanjing Drum Tower Hospital
2019-2023
Chongqing University of Arts and Sciences
2022
Mianyang Central Hospital
2020
Shangqiu First People's Hospital
2019
Purpose: Melittin (MPI) is a potential anticancer peptide due to its abilities of antitumor and immunomodulatory functions. Epigallocatechin-3-Ogallate (EGCG), major extract green tea, has shown great affinity for various types biological molecules, especially peptide/protein drugs. The aim this study prepare fluoro- nanoparticle (NP) formed by self-assembly fluorinated EGCG (FEGCG) MPI, evaluate the effect fluorine modification on MPI delivery their synergistic effect. Methods:...
Abstract Background Long noncoding RNA urothelial carcinoma‐associated 1 (lncRNA‐UCA1) is generally recognized as an oncogenic molecule in several human malignant tumors. However, the available evidence does not necessarily imply unequivocal causal function of UCA1 glioblastoma. The current study was aimed to probe biological lncRNA‐UCA1 glioblastoma cell lines. Besides, we further investigated potential mechanisms. Methods Cell viability, apoptosis, well migration and invasion were measured...
Objective Cancer remains the leading killer of human health worldwide. It has been shown that matrix metalloproteinase-1(MMP1) is related to poor prognosis in cancers such as BRCA, CESC and COAD. However, systematic pan-cancer analysis about prognostic immunological roles MMP1 not explored. Here, purpose this study was investigate confirm cancer-promoting effect pancreatic cancer. Methods In our study, bioinformatics were first used analyze data from multiple databases. Then, several tools...
Background: The retrieved lymph node (LN) count has been confirmed as a prognostic indicator in various cancers. However, the correlation between LN counts and patient prognosis gastric cancer with node-positive is not fully studied. Methods: A total of 8475 patients undergoing gastrectomy Surveillance, Epidemiology, End Results Program (SEER)-registered were analyzed. Kaplan-Meier methods multivariable Cox regression models used to analyze long-term outcomes risk factors. Moreover,...
Diverse clinical observations and basic studies have been conducted to explore the implications of analgesic medications in liver diseases. However, direct causal relationship between prescription use (PAU) risk cancer precancerosis remains unclear. Thus, we aimed reveal conceivable effect PAU on precancerosis, with immune cells as mediating factors. Two-sample Mendelian randomization (MR) analyses were performed ascertain causality precancerosis. Sensitivity analysis approaches employed...
Normal bovine adrenocortical cells and some human fibroblasts can be transformed by SV40T H-Ras in a Ras-dependent manner. We recently reported that high levels of Ras derived from 5' LTR retrovirrus induce highly malignant fast growing tumors, while lower internal ribosome entry site (IRES) promotes slower tumor growth loss malignancy. CMV promoters resulted much malignancy growth. Further studies showed the tumors formed presence dominant negative P53 (P53DD) had fewer apoptotic grew...
Hepatocellular carcinoma is a common malignant tumor of the digestive system with poor prognosis. The high recurrence rate and metastasis after surgery reduce survival time patients. Therefore, assessing overall patients hepatocellular hepatectomy critical to clinicians' clinical decision-making. Conventional assessment systems (such as lymph node Barcelona carcinoma) are obviously insufficient in This research devoted development nomogram tools assess probability undergoing liver...
Background Hepatocellular carcinoma (HCC) is one of the malignant tumors with high morbidity and mortality worldwide. Immunotherapy has emerged as an increasingly important cancer treatment modality. However, potential relationship between immune genes HCC still needs to be explored. The purpose this study construct a new prognostic risk signature predict prognosis patients based on expression immune-related (IRGs) explore its mechanism. Methods We analyzed gene data 332 patient samples 46...
Growing evidence implicates that miRNAs can interact with long non-coding RNAs (lncRNAs) to regulate target mRNAs through competitive interactions. However, this mechanism tumorigenesis and cancer progression remains largely unexplored. Long act as competing endogenous (ceRNAs), which play a significant role in regulating gene expression. The purpose of our study was determine potential lncRNA biomarkers predict the prognosis HCC by comprehensive analysis ceRNA network. edgeR package used...