A5100378107- melanin and skin pigmentation
- Biochemical Analysis and Sensing Techniques
- Skin Protection and Aging
- RNA regulation and disease
- Genetic Associations and Epidemiology
- Hair Growth and Disorders
- Urological Disorders and Treatments
- Myofascial pain diagnosis and treatment
- SARS-CoV-2 and COVID-19 Research
- Genetic and phenotypic traits in livestock
- Trace Elements in Health
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 Clinical Research Studies
- Genetic Mapping and Diversity in Plants and Animals
- Health, Environment, Cognitive Aging
- Heavy Metal Exposure and Toxicity
- Olfactory and Sensory Function Studies
- Restraint-Related Deaths
- Biochemical Acid Research Studies
- Antioxidant Activity and Oxidative Stress
- Mesenchymal stem cell research
- Atherosclerosis and Cardiovascular Diseases
- Neural Networks and Reservoir Computing
- Bioactive Compounds and Antitumor Agents
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Wannan Medical College
2022-2025
Jiangnan University
2025
Women's Hospital
2025
Chinese Academy of Sciences
2013-2024
Institute of Optics and Electronics, Chinese Academy of Sciences
2023-2024
University of Chinese Academy of Sciences
2017-2023
Huazhong University of Science and Technology
2022-2023
Erasmus MC
2020-2023
Beijing Institute of Genomics
2013-2023
Shanghai Center For Bioinformation Technology
2021-2023
The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report large genome-wide association study of ease tanning in 176,678 subjects European ancestry. We identify significant with ability at 20 loci. confirm previously identified associations six these loci, and 14 novel which ten have never been associated pigmentation-related phenotypes. Our results also suggest that variants the AHR/AGR3 locus, cutaneous malignant melanoma underlying mechanism...
A GWAS including 192,986 European and 1636 Asian participants identifies 50 novel discrete associations with eye color.
Abstract Photonic spin‐orbit interactions describe the between spin angular momentum and orbital of photons, which play essential roles in subwavelength optics. However, influence frequency dispersion on photonic angular‐momentum coupling is rarely studied. Here, by elaborately designing contribution geometric phase waveguide propagation phase, dispersion‐enabled symmetry switching experimentally demonstrated. This notion may induce many exotic phenomena be found enormous applications, such...
Abstract Introduction Recurrent spontaneous abortion (RSA) is associated with maternal-fetal interface dysfunction, particularly abnormal trophoblast invasion and proliferation. However, our understanding of the cause RSA remains limited. Methods Plasma Trp Kyn levels were measured in two groups using enzyme-linked immunosorbent assay. Immunofluorescence western blot analyses employed to evaluate expression IDO1, VEGFA, proteins epithelial-mesenchymal transition (EMT) villous decidual...
Background We discovered that vitiligo was associated with sexual dysfunction in clinical diagnosis and treatment; however, no further analysis had been performed due to a lack of data.Objective This study aimed clarify the relationship between dysfunction.Methods searched six databases (PubMed, Embase, Cochrane, China National Knowledge Infrastructure, Science Technology Journal, Wanfang Data Service Platform) for nearly 40 years.Results According search strategy, 91 relevant studies were...
Abstract Genetic prediction of male pattern baldness (MPB) is important in science and society. Previous genetic MPB models were limited by sparse marker coverage, small sample size, and/or data dependency the different analytical steps. Here, we present novel for based on a large set markers independent subsample sets drawn among 187,435 European subjects. We selected 117 SNP predictors within 85 distinct loci from list 270 previously MPB-associated SNPs 55,573 males UK Biobank Study...
Skin pigmentation functions as a shield to prevent UV damage the DNA of epidermal cells. A good number GWASs on skin color variation or photosensitivity have been conducted that discovered large associated loci (Ganguly et al., 2019Ganguly K. Saha T. A. Dutta Banerjee S. Sengupta D. al.Meta-analysis and prioritization human pigmentation-associated GWAS-SNPs using ENCODE data-based web-tools.Arch Dermatol Res. 2019; 311: 163-171Google Scholar). Polymorphisms/mutations at these used study...
Alzheimer's disease (AD) is the highest risk of COVID-19 infection, hospitalization, and mortality. However, it remains largely unclear about link between AD outcomes. ACE2 an entry receptor for SARS-CoV-2. Circulating a novel biomarker death associated with
Gingival-derived mesenchymal stem cells (GMSCs) have recently been harvested; however, the use of GMSCs in periodontal tissue engineering requires further study. The present study established an indirect co‑culture system between rat apical tooth germ‑conditioned medium (APTG‑CM) and GMSCs, order to determine effects on differentiation vitro vivo. Using limiting dilution technique, single‑colony derived human ligament (PDLSCs) were isolated expanded obtain homogeneous populations. PDLSCs...
Predicting appearance phenotypes from genotypes is relevant for various areas of human genetic research and applications such as epidemiology, history, anthropology, particularly in forensics. Many phenotypes, thus their underlying genotypes, are highly correlated, with pigmentation traits serving primary examples. However, all available prediction models, including those currently used forensic DNA phenotyping, ignore phenotype correlations. Here, we investigated the impact correlations on...
Follicle-stimulating hormone (FSH) and luteinizing (LH) play critical roles in female reproduction, while the underlying genetic basis is poorly understood. Genome-wide association studies (GWASs) of FSH LH levels were conducted 2590 Chinese females including 1882 polycystic ovary syndrome (PCOS) cases 708 controls. GWAS for level identified multiple variants at FSHR showing genome-wide significance with top variant (rs2300441) located intron FSHR. The A allele rs2300441 led to a reduced...
Abstract Nonlinear optical metasurfaces provide nanoscale‐level control of harmonic waves, making them highly promising platforms for both fundamental research and applications in nonlinear optics. However, the traditional selection rules theory, which has long served as a guiding principle meta‐optics, is local neglects significance meta‐atomic lattice symmetry. In addition, achieving high‐efficiency generation along with Pancharatnam‐Berry (PB) phase remains challenging. To this end, novel...