A5102836739- Hormonal and reproductive studies
- Respiratory viral infections research
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Neonatal Respiratory Health Research
- Liver Disease Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Hemoglobinopathies and Related Disorders
- SARS-CoV-2 and COVID-19 Research
- Circular RNAs in diseases
- Iron Metabolism and Disorders
- Renal Transplantation Outcomes and Treatments
- Vitamin D Research Studies
- Bariatric Surgery and Outcomes
- Folate and B Vitamins Research
- Stress Responses and Cortisol
- Pharmacological Effects and Assays
- Adrenal Hormones and Disorders
- Sexual Differentiation and Disorders
- Vitamin C and Antioxidants Research
- Cell Adhesion Molecules Research
- Alcohol Consumption and Health Effects
- Immune cells in cancer
- Extracellular vesicles in disease
Guangzhou University of Chinese Medicine
2015-2024
Yue Bei People's Hospital
2022-2024
Shantou University Medical College
2022-2024
Shantou University
2022-2024
Key Laboratory of Guangdong Province
2024
Guangdong Medical College
2023
Affiliated Hospital of Guangdong Medical College Hospital
2023
Guangzhou University
2022
Abstract Platelet αIIbβ3 integrin and its ligands are essential for thrombosis hemostasis, play key roles in myocardial infarction stroke. Here we show that apolipoprotein A-IV (apoA-IV) can be isolated from human blood plasma using platelet β3 integrin-coated beads. Binding of apoA-IV to platelets requires activation integrin, the direct apoA-IV-αIIbβ3 interaction detected a single-molecule Biomembrane Force Probe. We identify aspartic acids 5 13 at N-terminus required binding which is...
Inflammation is a component of tumor progression mechanisms. Neutrophils are common inflammatory infiltrate in many tumors, but their regulation and functions neoplasia not understood. Here, we showed, detailed studies c-Met molecule 225 untreated patients with hepatocellular carcinoma (HCC), that high infiltration neutrophils HCC tissues determined malignant cell c-Met-associated clinical outcome patients. High HCCs were enriched predominantly invading edge HCCs; the accumulated major...
Background Hepatocellular carcinoma (HCC) is a malignant tumor with high rate of recurrence and m metastasis that does not respond well to current therapies has very poor prognosis. Disulfidptosis novel mode cell death been analyzed as therapeutic target for HCC cells. Methods This study integrated bulk ribonucleic acid (RNA) sequencing datasets, spatial transcriptomics (ST), single-cell RNA explore the landscape disulfidptosis immune microenvironment Results We developed model predict...
Oxidative stress is a major risk factor for neurodegenerative disease. The Kelch-like ECH-associated protein 1 (Keap1)–nuclear erythroid 2 related (Nrf2)–antioxidant response element (ARE) pathway one of the most potent defensive systems against oxidative stress. Selenepezil, selenium-based compound, was previously found to exhibit excellent acetylcholinesterase (AChE) inhibition, mimic endogenous glutathione peroxidase (GPx) activity, and scavenging activity hydrogen peroxide in vitro....
Abstract Introduction Haemoglobin A1c (HbA1c) is widely used in the management of diabetes. Therefore, reliability and comparability among different analytical methods for its detection have become very important. Materials A comparative evaluation performances (precision, linearity, accuracy, method comparison, interferences including bilirubin, triglyceride, cholesterol, labile HbA1c (LA1c), vitamin C, aspirin, fetal haemoglobin (HbF), E (Hb E)) were performed on Capillarys 2 Flex Piercing...
We aimed to describe the 25-hydroxyvitamin D (25(OH)D) status of southern Chinese individuals by a high-accuracy liquid chromatography tandem mass spectrometry (LC-MS/MS) method which can trace reference measurement procedure.From January 2018 June 2019, total 4775 were evaluated in our study. The serum levels parathyroid hormone (PTH) detected simultaneously 162 cases. 25(OH)D was determined LC-MS/MS, and PTH using routine automated analysers. distribution concentration, prevalence seasonal...
Abstract Background Human respiratory syncytial virus (RSV) is a leading cause of acute lower tract infection and hospitalization, especially in children. Highly mutagenic nature antigenic diversity enable the RSV to successfully survive human population. We conducted molecular epidemiological study during 2017–2021 investigate prevalence genetic characteristics RSV. Methods A total 6499 nasopharyngeal (NP) swabs were collected from hospitalized children at Department Pediatrics, Guangdong...
ABSTRACT Objective Researches on the epidemiology of various respiratory pathogens at multiple testing points in pediatric population are limited, and these crucial for prevention tract infections children. Methods We obtained 1788 upper swabs from children exhibiting symptoms infection (notably fever with a body temperature exceeding 38.5°C) across five hospitals Guangdong between November 2020 June 2022. used multiplex probe amplification (MPA) PCR to identify 11 viruses subsequently...
Abstract Coronavirus disease 2019 (COVID-19) can be screened and diagnosed through the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by real-time reverse transcription polymerase chain reaction. SARS-CoV-2 nucleic acid amplification tests (NAATs) have been rapidly developed quickly applied to clinical testing during pandemic. However, studies evaluating performance these NAAT assays are limited. We evaluated four NAATs, which were marked Conformité Européenne...
With time, the number of samples in clinical laboratories from therapeutic drug monitoring has increased. Existing analytical methods for blood cyclosporin A (CSA) monitoring, such as high-performance liquid chromatography (HPLC) and immunoassays, have limitations including cross-reactivity, time consumption, complicated procedures involved. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) long been considered reference standard owing to its high accuracy, specificity, sensitivity....
For patients who treated with tacrolimus after kidney transplant, therapeutic drug monitoring is essential to improve their prognosis. However, previous detection methods have limitations, such as the overestimation and unacceptable bias in immunoassays. Precision medicine has been challenged. The liquid chromatography-tandem mass spectrometry (LC-MS/MS) method recognized gold standard due its accuracy specificity, but lack of throughput complex process limits clinical application....
Atherosclerosis and related cardiovascular diseases pose severe threats to human health worldwide. There is evidence suggest that at least 50% of foam cells in atheromas are derived from vascular smooth muscle (VSMCs); the first step this process involves migration atherosclerotic lesions. Long non‑coding RNAs (lncRNAs) have been found play significant roles diverse biological processes. The present study aimed investigate role lncRNAs VSMCs. expression or mRNAs was detected using reverse...
The matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been widely applied in routine clinical microbiology laboratories as an efficient and reliable technique for diagnostic purpose. In this work, we evaluated the performance newly developed Zybio EXS3000 (Zybio Inc., China) microbial identification compared it with VITEK MS (bioMérieux, France). For study, a total 1340 isolates from various specimens were collected. These analyzed simultaneously...
The underlying pathogenic genes and effective therapeutic agents of Alzheimer's disease (AD) are still elusive. Meanwhile, abnormal copper metabolism is observed in AD brains both human mouse models.To investigate metabolism-related gene biomarkers for diagnosis therapy.The datasets (CMGs) were downloaded from GEO GeneCards database, respectively. Differentially expressed CMGs (DE-CMGs) performed through Limma, functional enrichment analysis the protein-protein interaction used to identify...