A5021998770- Intracerebral and Subarachnoid Hemorrhage Research
- Kruppel-like factors research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Fibroblast Growth Factor Research
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Autophagy in Disease and Therapy
- Axon Guidance and Neuronal Signaling
- Cell death mechanisms and regulation
- Heart Failure Treatment and Management
- Immune cells in cancer
- Synthesis of Organic Compounds
- Mycobacterium research and diagnosis
- Signaling Pathways in Disease
- Environmental Changes in China
- Colorectal Cancer Screening and Detection
- Neuroscience and Neural Engineering
- Acute Myocardial Infarction Research
- Neuroblastoma Research and Treatments
- Heart Rate Variability and Autonomic Control
- Caveolin-1 and cellular processes
- Forest, Soil, and Plant Ecology in China
- History of Medical Practice
Zhongshan Hospital
2024
Fudan University
2024
Affiliated Hospital of Nantong University
2008-2024
Nantong University
2011-2024
Qingdao Municipal Hospital
2005-2009
China West Normal University
2006
Dormant cancer cells that survive anticancer therapy can lead to recurrence and disseminated metastases prove fatal in most cases. Recently, specific dormant polyploid giant (PGCC) have drawn our attention because of their association with the clinical risk nasopharyngeal carcinoma (NPC) recurrence, as demonstrated by previous data. In this study, we report biological properties PGCC, including mitochondrial alterations, reveal autophagy is a critical mechanism PGCC induction. Moreover,...
Trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, has been shown to have neuroprotective, neurotrophic and anti-inflammatory properties in both animal cellular models of neurodegenerative disorders. In previous study ours, we demonstrated that TSA inhibited the proliferation increased differentiation neuronal precursor cells (NPCs). However, effects on Schwann (SCs) not yet fully elucidated. Thus, present study, using SCs derived from adult rat sciatic nerves, investigated...
INTRODUCTION: Postendoscopic submucosal dissection (ESD) coagulation syndrome (PECS) prevention is one of the common postoperative complications colorectal ESD. Considering increasing incidence PECS, it critical to investigate various methods. The objective this study was evaluate efficacy transrectal drainage tubes (TDTs) in PECS patients following METHODS: From July 2022 2023, a multicenter, randomized controlled clinical trial conducted 3 hospitals China. Patients with superficial lesions...
Objectives:To better understand the neuroprotective role of astrocytes in spinal cord injury (SCI), we investigated whether astrocyte-conditioned medium (ACM) can attenuate glutamate-induced apoptotic cell death primary cultured neurons.Methods:Spinal neurons were pretreated with ACM for 24 hours. Subsequently, they exposed to glutamate (125 μM) 1 hour. The then incubated Following that, measurements assessing viability and lactate dehydrogenase (LDH) release performed. Apoptosis was...
The aim of this study was to assess the value microarray technology for detection intracranial bacterial infection. A small gene chip prepared based on four pathogens commonly known cause infection and corresponding six types common resistance genes in Affiliated Hospital Nantong University Haian People's University. Cerebrospinal fluid samples were then collected from 30 patients with clinically diagnosed bacteria genes. results compared culture sensitivity test Department Clinical...
To investigate the effects of ketamine on autophagy and apoptosis astrocytes in cerebral cortex rats, determine whether nuclear factor-κB (NF-κB) pathway is involved regulation astrocytes.A total 36 male Sprague-Dawley (SD) rats were randomly divided into 3 groups: control group (Group C: intraperitoneal injection equal amount normal saline), glutamic acid G: 1 mg/kg acid) + GK: then 5 after 30 min). The each was taken successive administration for d. number glial fibrillary acidic protein...
Aged patients often suffer poorer neurological recovery than younger after traumatic brain injury (TBI), but the mechanisms underlying this difference remain unclear. Here, we demonstrate abnormal myelopoiesis characterized by increased neutrophil and classical monocyte output impaired nonclassical patrolling population in aged with TBI as well an murine model. Retrograde anterograde nerve tracing indicated that adrenergic input through central amygdaloid nucleus–bone marrow axis drives a...
To investigate the in vitro effect of short interfering RNAs (siRNAs) against Nogo receptor (NgR) on neurite outgrowth under an inhibitory substrate central nervous system (CNS) myelin. Three siRNA sequences NgR were designed and transfected into cerebellar granule cells (CGCs) to screen for most efficient sequence by using reverse transcription polymerase chain reaction (RT-PCR) immunofluorescence staining. 1 was found which then CGCs grown CNS myelin observe its disinhibition outgrowth....
Neuronal apoptosis is regarded as one of the most important pathophysiological changes intracerebral hemorrhagic (ICH) stroke—a major public health problem that leads to high mortality rates and functional dependency. Mitogen-and stress-activated kinase (MSK) 1 implicated in various biological functions different cell types, including proliferation, tumorigenesis responses stress. Our previous study showed MSK1 phosphorylation (p-MSK1) related regulation LPS-induced astrocytic inflammation,...