A5101542218- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Spinal Cord Injury Research
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- RNA modifications and cancer
- Heat shock proteins research
- Receptor Mechanisms and Signaling
- Cellular Mechanics and Interactions
- Medical Research and Treatments
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Safety and Risk Management
- Genetic Associations and Epidemiology
- Photoacoustic and Ultrasonic Imaging
- Ferroptosis and cancer prognosis
- Functional Brain Connectivity Studies
- Telomeres, Telomerase, and Senescence
- Vanadium and Halogenation Chemistry
- ATP Synthase and ATPases Research
Affiliated Hospital of Nantong University
2012-2024
Nantong University
2013-2024
Lishui City People's Hospital
2024
Xian Yang Central Hospital
2024
Nantong Tumor Hospital
2024
Foshan Second People's Hospital
2022
Shanghai University
2021
Shanghai Jiao Tong University
2020-2021
Shanghai Ninth People's Hospital
2017
Shaanxi Research Association for Women and Family
2005
Abstract Trigeminal nerve injury–induced neuropathic pain is a debilitating chronic orofacial syndrome but lacks effective treatment. G protein–coupled receptors (GPCRs), especially orphan GPCRs (oGPCRs) are important therapeutic targets in medicine. Here, we screened upregulated oGPCRs the trigeminal ganglion (TG) after partial infraorbital transection (pIONT) and found that Gpr151 was most significantly oGPCRs. mRNA increased from pIONT day 3 maintained for more than 21 days. Furthermore,...
Trigeminal neuropathic pain is very common clinically, but effective treatments are lacking. Chemokines and their receptors have been implicated in the pathogenesis of chronic pain. This study explored role chemokine CXCL10 its receptor, CXCR3, trigeminal mice.Trigeminal was established by partial infraorbital nerve ligation (pIONL) wild-type Cxcr3-/- mice. Facial mechanical allodynia evaluated behavioral testing. A lentivirus containing Cxcr3 shRNA (LV-Cxcr3 shRNA) microinjected into...
Trigeminal neuropathic pain (TNP) is a significant health problem but the involved mechanism has not been completely elucidated. Toll-like receptors (TLRs) have recently demonstrated to be expressed in dorsal root ganglion and chronic pain. Here, we show that TLR8 was persistently increased trigeminal (TG) neurons model of TNP induced by partial infraorbital nerve ligation (pIONL). In addition, deletion or knockdown Tlr8 TG attenuated pIONL-induced mechanical allodynia, reduced activation...
Abstract Accumulating evidence reveals that hormone leptin, mainly produced by adipocyte, plays a unique role in promotion of liver fibrosis. Hepatic stellate cell ( HSC ) activation is key step fibrosis and peroxisome‐proliferator activated receptor γ PPAR γ) exerts crucial inhibition activation. Our previous researches demonstrated leptin reduced γ1 (a major subtype s) expression through GATA binding protein 2 2) to site around −2323 promoter. The present aimed examine the effect 3 on...
The cell surface glycoprotein Trop2 is overexpressed in various types of epithelial cancer. Laryngeal carcinoma one the most common head and neck cancer a previous study, expression laryngeal squamous (LSCC) was identified as an independent prognostic factor. However, biological significance LSCC development remains unclear. In current protein fresh tissue paracancerous investigated using western blotting. Hep2 line subsequently suppressed by transfection with small interfering RNA (siRNA)....
HCLS1‑associated protein X‑1 (HAX‑1) is highly expressed or overexpressed in various types of human tumor, and its overexpression associated with cancer metastasis cellular proliferation. However, the precise molecular mechanism involved HAX‑1‑associated proliferation hypopharyngeal carcinoma unknown. The present study aimed to investigate role HAX‑1 carcinoma. Reverse transcription‑quantitative polymerase chain reaction analysis western blotting indicated that was specimens. MTT, clone...
Abstract Age-related hearing loss (ARHI) is the most common sensory disorder in elderly. Although telomere attrition has been shown as a determinant pathobiology of various age-related diseases, it remains unknown whether length associated with ARHI. We hypothesized that decreased leukocyte (LTL) increased risk Thus, we measured LTL 666 ARHI and 43 controls by an established quantitative PCR technique. Four audiogram shape subtypes ARHI, including “flat (FL)”, “2–4 kHz abrupt (AL) shape”, “8...
Laryngeal cancer is one of the most common fatal cancers among head and neck carcinomas, whose mechanism, however, remains unclear. The proneural basic-helix-loop-helix protein achaete-scute complex homologue-1, a member basic helix-loop-helix family, plays very important role in many cancers. This study aims to explore clinical value mechanism homologue-1 laryngeal cancer. Methods including Cell Counting Kit-8, flow cytometry, Transwell invasion assays, scratch assay were adopted further...
The present study explored the role of LAMP3 and related molecular mechanisms in efficacy radiation exposure laryngeal squamous cell carcinoma (LSCC). A lentivirus vector containing gene was transfected into HEp-2 cells to construct siRNA-LAMP3 complementation (siLAMP3+LAMP3) groups. Treatment with 4 Gy or 8 administered evaluate therapy. Apoptosis detected by Annexin V/propidium iodide double staining. Cell migration invasion were measured vitro using Transwell Matrigel assays. Downstream...
Hepatic fibrosis is a spontaneous wound-healing response triggered by chronic liver injury. Pien Tze Huang (PZH), traditional Chinese herbal medicine, has been widely used to treat various hepatic diseases in Asia. We CCl4-induced mouse model establish PZH group of mice treated with and control without any treatment. performed RNA-seq mass spectrometry sequencing investigate the mechanism identified multiple differentially expressed transcripts (DETs) proteins (DEPs) that may be drug targets...
Studies have suggested that salicylate affects neuronal function via interactions with specific membrane channels/receptors. However, the effect of on activity and synaptic morphology hippocampal Cornu Ammonis (CA) 1 area remains to be elucidated. The activation immediate‑early genes (IEGs) was reported correlate activity, in particular activity‑regulated cytoskeleton‑associated protein early growth response gene 1. aim present study evaluate expression these IEGs, as well N‑methyl...