A5100616959- Advanced Measurement and Metrology Techniques
- EEG and Brain-Computer Interfaces
- Spine and Intervertebral Disc Pathology
- Cardiac electrophysiology and arrhythmias
- Bone and Dental Protein Studies
- Fluoride Effects and Removal
- Diabetes Management and Research
- Folate and B Vitamins Research
- Insect and Arachnid Ecology and Behavior
- Mesenchymal stem cell research
- Spinal Fractures and Fixation Techniques
- Apelin-related biomedical research
- Erythropoietin and Anemia Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Alcoholism and Thiamine Deficiency
- Heart Failure Treatment and Management
- Neurobiology and Insect Physiology Research
- Traditional Chinese Medicine Studies
- Healthcare and Venom Research
- Cancer Research and Treatments
- Cardiac Valve Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Atrial Fibrillation Management and Outcomes
- Cardiac Fibrosis and Remodeling
Army Medical University
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Dalian Medical University
2025
Hangzhou Children's Hospital
2019-2025
Nantong University
2021-2025
Inner Mongolia Medical University
2018-2025
Renmin Hospital of Wuhan University
2024
Wuhan University
2014-2024
Second Military Medical University
2018-2024
The growth arrest special 5 (GAS5) is known to be involved in various cancers. However, its expression regulation remains unclear. Polymorphisms the promoter region of GAS5 may affect and associated with cancer susceptibility. In this research, we first evaluated association a 5-base pair indel polymorphism (rs145204276) hepatocelluar carcinoma (HCC) susceptibility Chinese populations. Logistic regression analysis showed that deletion allele rs145204276 significantly increased risk HCC two...
Abstract Object Patients with type 2 diabetes mellitus (T2DM) are at higher risk of developing atherosclerosis. Previous studies have analyzed the factors associated diabetic macrovascular disease, although whether these applicable to T2DM patients carotid atherosclerosis remains unclear. Therefore, aim this study was investigate for formation atherosclerotic plaque in hospitalized and provide a theoretical basis early prevention treatment patients. Methods A total 949 were included study....
The clinical benefits of combining immunotherapy with chemotherapy and surgical resection in pancreatic adenocarcinoma remain unclear. expression significance HIF1A circulating tumor cells (CTCs) remains limited.
The cervical uncinate process is a unique structure of the spine that undergoes significant changes in its morphological characteristics with age, and these may be related to osteoporosis. This study aimed observe distribution cancellous bone features using micro-computed tomography (Micro-CT) gain deeper understanding microstructure. We performed Micro-CT scans on 31 sets C3-C7 vertebrae, total 155 intact samples, subsequently used measurement software system obtain parameters process....
Recognition memory improves with child development, but the neural mechanisms underlying such improvement and developmental variation remain poorly understood. Herein, we investigated how representations during encoding retrieval phases of recognition change age, using representational similarity analysis in a sample children aged 6-13 years (n = 137). Our results indicated that have distinct patterns development. Similarly, model-free approach, confirmed there is key stage (about 9-10 old)...
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed an unprecedented demand for accurate and cost-effective diagnostic assays to discriminate between different variants. Whilst many bioassays have been successfully demonstrated SARS-CoV-2 detection, diagnosis its variants remains challenging mainly relies on time-consuming costly sequencing techniques. Herein, we proposed a triplevalent tetrahedral DNA nanostructure (tTDN) with three overhang isotope...
There are conflicting reports on the link between micronutrient selenium and prevalence of diabetes. To investigate possibility that acts as a "double-edged sword" in diabetes, cDNA microarray profiling two-dimensional differential gel electrophoresis coupled with mass spectrometry were used to determine changes mRNA protein expression pancreatic liver tissues diabetic db/db mice response dietary selenate supplementation. Fasting blood glucose levels increased continuously administered...
This study aimed at investigating the therapeutic effect and mechanism of pioglitazone metformin complex preparation (PM) in polycystic ovary syndrome (PCOS) comorbid psychological distress.Seventy-five patients with PCOS distress were randomly allocated into PM, metformin, placebo groups. The primary efficacy measure was change from baseline to week 12 on Symptom Checklist 90-R (SCL-90-R) scores. NLRP3 inflammasome, IL-1β, IL-6, TNF-α, biochemical parameters determined 12. participants...
The telomerase reverse transcriptase (TERT) has long been pursued as a direct therapeutic target in human cancer, which is currently hindered by the lack of effective specific inhibitors TERT. FOS/GABPB/(mutant) TERT cascade plays critical role regulation mutant TERT, FOS acts transcriptional factor for GABPB to up-regulate expression GABPB, turn activates but not wild-type promoter, driving TERT-promoted oncogenesis. In present study, we demonstrated that inhibiting this targeting using...
Background Tie2-expressing monocytes (TEMs) are found in various tumors, involved forming tumor blood vessels and expressing several important proangiogenic factors. The goals of this study were to evaluate the value TEMs diagnosing predicting prognosis hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Methods Flow cytometry was performed identify count peripheral from HCC patients (n = 84) receiving hepatectomy, HBV cirrhotic 21), benign tumors 15) healthy volunteers 23)....
The adipocytokine, apelin-13, is an abundantly expressed peptide in the nervous system. Apelin-13 protects brain against ischemia/reperfusion injury and attenuates traumatic by suppressing autophagy. However, secondary apelin-13 effects on injury-induced neural cell death blood-brain barrier integrity are still not clear. Here, we found that significantly decreases cerebral water content, mitigates destruction, reduces aquaporin-4 expression, diminishes caspase-3 Bax expression cortex...
Hyperglycemia plays a major role in the development of diabetic macrovascular complications, including atherosclerosis and restenosis, which are responsible for most disability mortality patients. Osteopontin (OPN) is an important factor involved atherogenesis, hyperglycemia enhances transcriptional activity FoxO1 closely association with insulin resistance diabetes. Here, we showed that plasma OPN levels were significantly elevated type 2 patients positively correlated glycated albumin...
Objective: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Metrnl a secreted protein that plays an important role in The aim this study was to investigate DKD-related factors and correlation between serum levels severity DKD. Methods: Ninety-six type 2 diabetes mellitus (T2DM) patients 45 DKD were included study. A range parameters measured simultaneously, including waist-to-hip ratio (WHR), body mass index (BMI), urinary albumin/creatinine (UACR),...
Cardiovascular diseases (CVDs) are a major public health concern. The impact of dietary components on CVD risk has been recognized, but their interactions require further investigation. This study aimed to examine the associations between nutrient intake and assess potential causal relationships via Mendelian randomization.
The probe tip of a micro-coordinate Measuring Machine (micro-CMM) is microsphere with diameter hundreds microns, and its sphericity generally controlled within tens to nanometers. However, the accurate measurement morphology difficult because small size high precision requirement. In this study, method two scanning probes proposed obtain dimensions including microsphere. A series maximum cross-sectional profiles in different angular directions are scanned simultaneously differently by...