A5029833562- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Colorectal and Anal Carcinomas
- Infectious Diseases and Mycology
- Melanoma and MAPK Pathways
- Nonmelanoma Skin Cancer Studies
- Ear and Head Tumors
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- RNA modifications and cancer
- CAR-T cell therapy research
- Protein Degradation and Inhibitors
- NF-κB Signaling Pathways
- Single-cell and spatial transcriptomics
- Voice and Speech Disorders
- Cerebrovascular and Carotid Artery Diseases
- Lung Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Histone Deacetylase Inhibitors Research
Beijing Tongren Hospital
2018-2025
Capital Medical University
2018-2025
University of Science and Technology of China
2024
In this study, a next-generation sequencing strategy on 16S ribosomal RNA (16S rRNA) gene was employed to analyze 70 oral samples from 32 patients with throat cancer, nine vocal cord polyp, and 29 healthy individuals (normal controls). Using strategy, we demonstrated, for the first time, that salivary microbiota of cancer were significantly different those polyp individuals. We observed beta diversity group divergent both normal groups, while alpha-diversity indices such as Chao1 estimator...
Hypopharyngeal squamous cell carcinoma (HSCC) is a highly malignant tumor type in the head and neck region. In recent years, neoadjuvant therapy has significantly improved laryngeal preservation rate among patients. However, there are variations efficacy of therapy, identification reliable predictive biomarkers for its remains challenging research focus. This study aims to explore correlation between expression P53, P16, Ki67 response therapy. A retrospective analysis was conducted on 120...
Human papillomavirus (HPV) infection is closely related to upper respiratory mucosal lesions, and the most common disease adult papilloma, which has a certain probability of cancer transformation.This study conducted in vitro tissue cell experiments explore inflammatory mechanisms associated with HPV + laryngeal papilloma. We compared differential expression AIM2 IL-1β between (High-risk) negative positive papilloma patients. In were investigate differences AIM2, Caspase-1, HPV- HPV+ cells....
Abstract The efficacy of the first-line treatment for hypopharyngeal carcinoma (HPC), a predominantly male cancer, at advanced stage is only about 50% without reliable molecular indicators its prognosis. In this study, HPC biopsy samples collected before and after are classified into different groups according to responses. We analyze changes tumor microenvironment (TME) single-cell level in response identify three gene modules associated with estimate cell constitutions based on bulk...
The BTF3 is involved in oncogenesis, while the biological roles HSCC remain unclear. aim of this study was to explore impact knockdown on phenotypes human vivo and vitro. expression assessed normal tissues. In vitro experiments were performed cell line, including proliferation, cycle, apoptosis. Moreover, nude mice used evaluate growth xenograft tumors. Finally, gene chip potential signaling pathways BTF3, with confirmation BTF3-related genes. Our results showed elevated observed tumors...
Mucosal melanoma of the nasal cavity and paranasal sinus is always associated with poor prognosis, 5-year overall survival does not exceed 40%. Our study aimed to compare intraoperative conditions prognosis different surgical techniques determine optimum approach for patients mucosal sinus. This was a retrospective analysis 54 who received treatment at Beijing Tongren Hospital between January 2004 December 2016. The were divided into two groups: those endoscopic surgery underwent traditional...
Although poorly differentiated is rare in head and neck squamous cell carcinoma (HNSCC), its prognosis are worse with high rate of local recurrence distant metastasis (DS). Therefore, this study hopes to carry out prospective clinical research on different treatment options for patients explore the scheme more suitable these patients.This a cohort study. We selected larynx or hypopharynx (stage I-IV, T1-4a, N0-2, M0). The intervention methods stage I-II as follows: surgery, induction...
Objective: To study the clinical characteristics of mucosal melanoma in head and neck, including risk factors affecting distant metastasis, recurrence survival rate, to provide basis for individualized treatment neck. Methods: The data 117 cases neck treated from January 2004 June 2016 Beijing Tongren Hospital were analyzed retrospectively, prognosis, metastasis local analyzed.Kaplan-Meier analysis was used analysis, Log-Rank test comparison between groups. Results: follow-up time 5-139...
Background: The prognosis of mucosal melanoma is poor, and the difference in clinical between patients with without pigment needs further study.Aim: To analyze data head neck melanoma, compare pigment.Material methods: amelanotic were matched pigmented type according to age, sex, stage, location disease, treatment history, tobacco alcohol history. Kaplan–Meier Cox proportional risk regression model was used for analyzation.Results: 46 included this study. overall survival rate...
Abstract Objective To retrospective analysis of the epidemiological and clinical characteristics parotid gland tumors, to explore value ultrasound in differentiation benign malignant tumors. Methods The data 350 patients with tumors our hospital from 2002 2022 were retrospectively analyzed. These examined by ultrasound. postoperative pathological test results used as “gold standard” verify analyze color Doppler differential diagnosis (PT). Results male‐to‐female ratio was 1.16:1. age ranged...
Immune system biomarkers in cancer pathogenesis offer new therapeutic avenues, as seen cytokine (CK) profiles of laryngeal and hypopharyngeal tumors. A retrospective analysis was conducted on 58 patients with tumors 27 benign vocal cord lesions to explore the role serum CKs these diseases’ characteristics immunotherapy. The differences levels 12 cytokines were measured. Additionally, study examined correlation between T helper cells (Th)1/Th2 clinical immunotherapy efficacy cancers. results...
Head and neck mucosal melanoma is one of the most common types in China, but prognosis worse than other types, there no effective treatment plan to improve patient survival. This study analyzes efficacy hypofractionation radiotherapy combined with PD-1 inhibitor head melanoma, as well its impact on tumor immune microenvironment. NPSG mice were used construct a humanized bilateral lesion model system. The models divided into an RT (8 Gy)+anti group, (2 GyX4)+anti Anti Gy) blank group....
The aim of the present study was to analyze characteristics angiogenic factors in patients with hypopharyngeal cancer, and effects these on induction chemotherapy, patient prognosis survival. Data from 60 eligible cancer that were treated between January 2012 December 2016 collected retrospectively. differential expression tumor peritumoral tissues analyzed retrospectively assess association five differentially expressed genes, including interleukin (IL)-1β, transforming growth factor...