A5006706169- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Health, Environment, Cognitive Aging
- EEG and Brain-Computer Interfaces
- Neurological Disease Mechanisms and Treatments
- Neurobiology of Language and Bilingualism
- Advanced Neuroimaging Techniques and Applications
- Identity, Memory, and Therapy
- Frailty in Older Adults
- Nicotinic Acetylcholine Receptors Study
- Reading and Literacy Development
- Blood Pressure and Hypertension Studies
- Epilepsy research and treatment
- Olfactory and Sensory Function Studies
- Memory Processes and Influences
- Transcranial Magnetic Stimulation Studies
- Cognitive Functions and Memory
- Hearing Loss and Rehabilitation
- Cholinesterase and Neurodegenerative Diseases
- 3D IC and TSV technologies
- Nutritional Studies and Diet
- Aging and Gerontology Research
- Genetic Associations and Epidemiology
Macquarie University
2015-2024
Australian Hearing
2015-2023
ARC Centre of Excellence in Cognition and its Disorders
2012-2021
Australian Research Council
2013-2019
The University of Melbourne
2001-2017
Florey Institute of Neuroscience and Mental Health
2016-2017
Austin Health
2007-2016
CSIRO Health and Biosecurity
2016
Mental Health Research Institute
2007-2016
The University of Western Australia
2015
<b>Objective: </b> To compare brain β-amyloid (Aβ) burden measured with [<sup>11</sup>C]Pittsburgh Compound B (PIB) PET in normal aging, Alzheimer disease (AD), and other dementias. <b>Methods: Thirty-three subjects dementia (17 AD, 10 Lewy bodies [DLB], 6 frontotemporal [FTD]), 9 mild cognitive impairment (MCI), 27 age-matched healthy control (HCs) were studied. Aβ was quantified using PIB distribution volume ratio. <b>Results: Cortical binding markedly elevated every AD subject regardless...
The Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging aimed to recruit 1000 individuals aged over 60 assist with prospective research into Alzheimer's disease (AD). This paper describes the recruitment cohort gives information about methodology, baseline demography, diagnoses, medical comorbidities, medication use, cognitive function participants.Volunteers underwent a screening interview, had comprehensive testing, gave 80 ml blood, completed health lifestyle...
β-amyloid (Aβ) deposition is pathognomic for Alzheimer's disease (AD), but may occur in normal elderly people without apparent cognitive effect. Episodic memory impairment an early and prominent sign of AD, its relationship with Aβ burden non-demented persons AD patients unclear. We examined this using 11C-PIB-PET as a quantitative marker vivo healthy ageing (HA), mild (MCI) AD. Thirty-one 33 MCI 32 HA participants completed neuropsychological assessment brain scan. Multiple linear...
Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer's disease (LOAD). However, LOAD genetic architecture and prediction are unclear. Here we estimate the optimal P-threshold (P
Objective Biomarkers for Alzheimer disease (AD) can detect the pathology in asymptomatic subjects and individuals with mild cognitive impairment (MCI), but their prognosis remains uncertain. We aimed to determine prognostic value of β‐amyloid imaging, alone combination memory performance, hippocampal atrophy, apolipoprotein E ε4 status nondemented, older individuals. Methods A total 183 healthy (age = 72.0 ± 7.26 years) 87 participants MCI 73.7 8.27) Australian Imaging, Biomarkers, Lifestyle...
Abstract Introduction The objective of this study was to determine the utility subjective memory decline (SMD) predict episodic change and rates clinical progression in cognitively normal older adults with evidence high β‐amyloid burden (CN Aβ+). Methods Fifty‐eight CN Aβ+ participants from Australian Imaging, Biomarkers, Lifestyle responded an SMD questionnaire underwent comprehensive neuropsychological assessments. Participant data for three follow‐up assessments were analyzed. Results In...
The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), 211 Alzheimer's disease dementia (AD)) an 'Inception cohort' who underwent detailed ssessments every 18 months. Over the past decade, additional 1247 subjects have been added 'Enrichment (as 10 April 2019). Here we provide overview these Inception Enrichment cohorts more than 8,500 person-years...
Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it unknown whether continuous age- AD-related cortical degradation alters asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order regions exhibiting pronounced at age ~20 also asymmetry-loss across lifespan. Hence, accelerated thinning (previously) thicker homotopic hemisphere a aging. This...
The sulci and gyri found within the anterior cingulate (AC), across cerebrum generally, have been to vary in location complexity from one individual next, making it difficult analyze imaging data accurately systematically. In this study, we examined nature of morphometric variance AC left right cerebral hemispheres using high-resolution structural magnetic resonance (MRI) acquired 176 healthy volunteers. Depending on presence a paracingulate sulcus (PCS) its antero-posterior extent, three...
ABSTRACT Background: The prognostic value of subjective memory complaints (SMCs) in the diagnosis dementia Alzheimer's type is unclear. While some studies have found an association between SMCs and cognitive decline, many a stronger with depression, which raises questions about their diagnostic utility. Methods: We examined cross-sectional SMC severity (as measured using MAC-Q, brief questionnaire) affect, memory, disease (AD) biomarkers (β-amyloid deposition apolipoprotein E ε4 (APOEε4)...
The aim of this study was to validate the CogState Brief Battery, which assesses psychomotor, attentional, working memory, and visual learning functions, in healthy older people patients with mild cognitive impairment (MCI) Alzheimer's disease (AD), enrolled Australian Imaging, Biomarkers Lifestyle (AIBL) study. In adults, weak relationships between demographic variables (e.g., education, depression) performance were observed. AD MCI groups, magnitude greatest for tasks memory a negative...
Assessment of risk and early diagnosis Alzheimer's disease (AD) is a key to its prevention or slowing the progression disease. Previous research on factors for AD typically utilizes statistical comparison tests stepwise selection with regression models. Outcomes these methods tend emphasize single rather than combination factors. However, factors, any one alone, likely affect development. Genetic algorithms (GA) can be useful efficient searching variables best achievement (eg. accuracy...
Neuroimaging studies have shown that the neural mechanisms of motor imagery (MI) overlap substantially with execution (ME). Surprisingly, however, role several regions circuitry in MI remains controversial, a variability may be due to differences neuroimaging techniques, training, instruction types, or tasks used evoke MI. The objectives this study were twofold: (i) design novel task reliably invokes MI, provides reliable behavioral measure performance, and is transferable across imaging...
Retinal imaging may serve as an alternative approach to monitor brain pathology in Alzheimer's disease (AD). In this study, we investigated the association between retinal vascular and structural changes cerebral amyloid-β (Aβ) plaque load elderly cohort.We studied a total of 101 participants, including 73 subjects (79 ± 5 years, 22 male) with no clinical diagnosis AD but reporting some subjective memory change additional 28 (70 9 16 clinically established AD. Following complete dilated...
Abstract Objectives: The Addenbrooke’s Cognitive Examination (ACE) is a common cognitive screening test for dementia. Here, we examined the relationship between most recent version (ACE-III) and its predecessor (ACE-R), determined ACE-III cutoff scores detection of dementia, explored with functional ability. Methods: Study 1 included 199 dementia patients 52 healthy controls who completed ACE-R. total domain were regressed on their corresponding ACE-R values to obtain conversion formulae. 2...
<h3>Objective:</h3> Although the <i>APOE</i> ϵ<i>4</i> allele is associated with more rapid decline in memory healthy older adults, significance of elevated cerebral β-amyloid (Aβ) load for longitudinal changes cognition unclear. <h3>Methods:</h3> Healthy and cognitively normal adults (n = 141; mean age 76 years) underwent PET neuroimaging Aβ, genotyping, cognitive assessment as part their baseline Australian Imaging Biomarkers Lifestyle study. Cognitive function was reassessed 18 months...
Olfactory deficits and increased amyloid-β (Aβ) burden are observed in people with amnestic mild cognitive impairment (aMCI); both factors may be predictive of Alzheimer's disease (AD). We explored whether olfactory identification is related to vivo measures Aβ using Pittsburgh Compound B (PiB) PET. Nineteen control, 24 aMCI, 20 AD participants completed an task underwent PiB PET scanning. Control performed better on showed lower binding than aMCI patients. There was a significant...
Abstract Background High β‐amyloid (Aβ) is associated with faster memory decline in healthy individuals and adults mild cognitive impairment (MCI). However, longer prospective studies are required to determine if Aβ‐related continues whether it increased rate of disease progression. Methods Healthy controls (HCs; n = 177) MCI (n 48) underwent neuroimaging for Aβ assessment at baseline. Cognition was reassessed 18 36 months later. Results Compared low‐Aβ HCs, high‐Aβ HC groups showed moderate...