A5069459052- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Gestational Trophoblastic Disease Studies
- Misinformation and Its Impacts
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Memory Processes and Influences
- Communication and COVID-19 Impact
- EEG and Brain-Computer Interfaces
- Media Influence and Health
- Vaccine Coverage and Hesitancy
- Thermal Regulation in Medicine
- Trigeminal Neuralgia and Treatments
- Respiratory Support and Mechanisms
- Geriatric Care and Nursing Homes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Healthcare cost, quality, practices
- Pain Mechanisms and Treatments
- Biosensors and Analytical Detection
- Management of metastatic bone disease
- Multiple Sclerosis Research Studies
- interferon and immune responses
University of California, San Francisco
2023-2024
Office of Infectious Diseases
2023
University of Manitoba
2022-2023
Methodist Sports Medicine
2023
Houston Methodist
2023
McMaster University
2020-2022
St. Jude Children's Research Hospital
2022
Children's Hospital
2022
University of Toronto
2022
Missouri State University
2020-2021
Abstract Objectives: The Addenbrooke’s Cognitive Examination (ACE) is a common cognitive screening test for dementia. Here, we examined the relationship between most recent version (ACE-III) and its predecessor (ACE-R), determined ACE-III cutoff scores detection of dementia, explored with functional ability. Methods: Study 1 included 199 dementia patients 52 healthy controls who completed ACE-R. total domain were regressed on their corresponding ACE-R values to obtain conversion formulae. 2...
Some individuals do not return to baseline health following SARS-CoV-2 infection, leading a condition known as long COVID. The underlying pathophysiology of COVID remains unknown. Given that autoantibodies have been found play role in severity infection and certain other post-COVID sequelae, their potential is important investigate. Here, we apply well-established, unbiased, proteome-wide autoantibody detection technology (T7 phage-display assay with immunoprecipitation next-generation...
The COVID-19 pandemic is the first where social media platforms relayed information on a large scale, enabling an "infodemic" of conflicting which undermined global response to pandemic. Understanding how circulated and evolved essential for planning future public health campaigns. This study investigated what types themes about were most viewed YouTube during 8 months pandemic, progressed over this period.We analyzed top-viewed COVID-19-related videos in English from December 1, 2019 August...
Type I interferons (IFNs) are essential innate immune proteins that maintain tissue homeostasis through tonic expression and can be upregulated to drive antiviral resistance inflammation upon stimulation. However, the mechanisms inhibit aberrant IFN upregulation in impacts of production on health disease remain enigmatic. Here, we report caspase-8 negatively regulates type by inhibiting RIPK1-TBK1 axis during across multiple cell types tissues. When is deleted or inhibited, RIPK1 interacts...
Abstract Advances in neuroimaging have permitted the non-invasive examination of human brain pain. However, a persisting challenge is objective differentiation neuropathic facial pain subtypes, as diagnosis based on patients’ symptom descriptions. We use artificial intelligence (AI) models with data to distinguish subtypes and differentiate them from healthy controls. conducted retrospective analysis diffusion tensor T1-weighted imaging using random forest logistic regression AI 371 adults...
Normative word frequency has played a key role in the study of human memory, but there is little agreement as to mechanism responsible for its effects. To determine whether affects binding probability or memory precision, we used continuous reproduction task examine working spatial positions words. In three experiments, after studying list five words, participants had report location one them on circle. Across experiments varied frequency, presentation rate, and proportion low-frequency...
ABSTRACT Some individuals do not return to baseline health following SARS-CoV-2 infection, leading a condition known as Long COVID. The underlying pathophysiology of COVID remains unknown. Given that autoantibodies have been found play role in severity infection and certain other post-COVID sequelae, their potential is important investigate. Here we apply well-established, unbiased, proteome-wide autoantibody detection technology (PhIP-Seq) robustly phenotyped cohort 121 with COVID, 64 prior...
Deaf children born to hearing parents lack continuous access language, leading weaker working memory compared and deaf parents. CopyCat is a game where communicate with the computer via American Sign Language (ASL), it has been shown improve language skills memory. Previously, depended on unscalable hardware such as custom gloves for sign verification, but modern 4K cameras pose estimators present new opportunities. Before re-creating using off-the-shelf hardware, we evaluate whether current...
Guidelines on cardiovascular disease (CVD) risk reassessment intervals are unclear, potentially leading to detrimental practice variation: too frequent can result in overtreatment and greater strain the healthcare system; infrequent could neglect of high patients who require medication. This study aimed understand different factors that general practitioners (GPs) consider when deciding interval for previously assessed primary CVD risk.This paper combines quantitative qualitative data...
Normative word frequency has played a key role in the study of human memory, but there is little agreement as to mechanism responsible for its effects. To determine whether affects binding probability or memory precision, we used continuous reproduction task examine working spatial positions words. In three experiments, after studying list five words, participants had report location one them on circle. Across experiments varied frequency, presentation rate and proportion low words each...
Introduction: Emotion regulation is an integral part of mental health, dynamically impacting brain function as one’s emotions change continuously throughout the day. Impairments in emotion are associated with a range psychiatric disorders. Although implications crucial to few studies have examined training strategies respect brain. Thus, this manuscript will propose affective brain-computer music interface (aBCMI) prototype for that generates by estimating from real-time...
Abstract To understand the roles of acute phase viral dynamics and host immune responses in PASC, we enrolled 136 participants within 5 days their first positive SARS-CoV-2 real-time PCR. Participants self-collected nasal specimens up to 21 times 28 after symptom onset; Interviewer-administered clinical questionnaires blood samples were collected at enrollment 9, 14, 21, 28, month 4 8 post-symptom. Defining PASC as presence any new or worse since infection reported 4-month visit, compared...
Introduction: Antibacterial resistance has accentuated the need for development of novel, efficacious pharmaceuticals. Structurally nanoengineered antimicrobial polypeptide polymers (SNAPPs) have shown promise as a candidate new antibacterial pharmaceutical class which may help overcome problem in humans or animals. Particularly, SNAPP with chemical formula (RGRGRGRGRGRG)4K2K-NH2 (4R6G6) been to exhibit negligible hemolysis while retaining low minimal inhibitory concentrations against...
Abstract Objective: The COVID-19 pandemic is the first where social media platforms relayed information on a large scale, enabling an “infodemic” of conflicting which undermined global response to pandemic. Understanding how circulated and evolved essential for planning future public health campaigns. This study investigated what types themes about were most viewed YouTube during 8 months pandemic, progressed over this period. Methods: We analyzed top-viewed COVID-19-related videos in...
Study Design: Systematic review. Objective: To examine the outcomes of customized 3-dimensional (3D) printed implants for spinal reconstruction after tumor resection. Summary Background Data: Various techniques exist Currently, there is no consensus regarding utility 3D-printed Materials and Methods: A systematic review was registered with PROSPERO performed according to “Preferred Reporting Items Reviews Meta-analyses” guidelines. All level I–V evidence studies reporting use resection were...
Abstract Recurrent hydatidiform molar pregnancies are characterized by uncontrolled proliferation of trophoblasts resulting in the failure embryo and placenta to develop properly. Previous studies genetically mapped a mutation NLRP7 as cause for recurrent pregnancies. The goal this study is identify human proteins that interact with NLRP7, especially those involved DNA acetylation methylation, which could lead development A yeast two-hybrid system using cDNA library was used screen...
Abstract Mutations in NLRP2 and NLRP7 genes result genetic maternal imprinting disorders. These have been identified to be effect regulating early embryo development idiopathic recurrent miscarriage. Previous research suggests that regulate DNA methylation immune signaling through inflammasome formation. However, the exact mechanisms underlying miscarriages are not known. In this study, we report a novel protein interaction of Human proliferation-associated 2G4 (PA2G4, aka: EBP1) with an...
Introduction: Alzheimer’s disease is a type of dementia characterized by buildup -amyloid plaques and neurofibrillary tangles. Prior to the development disease, patients may experience mild cognitive impairment, decline in abilities while maintaining independent function. Electroencephalography has shown promise as clinical predictor impairment. The purpose this study review existing literature on biomarkers using resting-state electroencephalography or event-related potentials differentiate...
<sec> <title>BACKGROUND</title> The COVID-19 pandemic is the first where social media platforms relayed information on a large scale, enabling an “infodemic” of conflicting which undermined global response to pandemic. Understanding how circulated and evolved essential for planning future public health campaigns. </sec> <title>OBJECTIVE</title> This study investigated what types themes about were most viewed YouTube during 8 months pandemic, progressed over this period....
Abstract Recurrent hydatidiform molar pregnancies are characterized by uncontrolled proliferation of trophoblasts resulting in the failure embryo and placenta to develop properly. Previous studies genetically mapped a mutation NLRP7 as cause for recurrent with abnormal methylation patterns. The goal this study is identify human proteins that interact NLRP7, especially those involved DNA acetylation methylation, which could lead development pregnancies. A yeast two-hybrid system using cDNA...