A5007769445- Inflammasome and immune disorders
- interferon and immune responses
- Immune Response and Inflammation
- Alzheimer's disease research and treatments
- Influenza Virus Research Studies
- EEG and Brain-Computer Interfaces
- Fire effects on ecosystems
- Neuroscience and Neural Engineering
- Nuclear Receptors and Signaling
- Heme Oxygenase-1 and Carbon Monoxide
- Wireless Body Area Networks
- Context-Aware Activity Recognition Systems
- Viral Infections and Vectors
- Non-Invasive Vital Sign Monitoring
- Viral Infections and Outbreaks Research
- MicroRNA in disease regulation
- Neuroscience of respiration and sleep
- Cytokine Signaling Pathways and Interactions
- Curcumin's Biomedical Applications
- Gaze Tracking and Assistive Technology
- Autophagy in Disease and Therapy
- Cutaneous lymphoproliferative disorders research
- Toxoplasma gondii Research Studies
- RNA Research and Splicing
- 14-3-3 protein interactions
Ulsan National Institute of Science and Technology
2023-2025
University of California, Los Angeles
2024
University of Tsukuba
2018-2022
St. Jude Children's Research Hospital
2020-2022
Biology of Infection
2021
Yonsei University
2009-2011
The University of Texas MD Anderson Cancer Center
2002
Cell death provides host defense and maintains homeostasis. Zα-containing molecules are essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell death, PANoptosis, whereas adenosine deaminase acting on RNA (ADAR1) serves as an editor to maintain Here, we identify characterize ADAR1's interaction with ZBP1, defining its role in regulation tumorigenesis. Combining interferons (IFNs) nuclear export inhibitors (NEIs) ZBP1-dependent PANoptosis. ADAR1 suppresses...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for disease 2019 (COVID-19), continues to cause substantial morbidity and mortality in ongoing global pandemic. Understanding fundamental mechanisms that govern innate immune inflammatory responses during SARS-CoV-2 infection is critical developing effective therapeutic strategies. Whereas interferon (IFN)–based therapies are generally expected be beneficial viral infection, clinical trials COVID-19 have...
Resistance to cell death is a hallmark of cancer. Immunotherapy, particularly immune checkpoint blockade therapy, drives immune-mediated and has greatly improved treatment outcomes for some patients with cancer, but it often fails clinically. Its success relies on the cytokines cytotoxic functions effector cells bypass resistance eliminate cancer cells. However, specific capable inducing in tumors mechanisms that connect across types remain unknown. In this study, we analyzed expression...
ABSTRACT Respiratory epithelial cell death by influenza virus infection is responsible for the induction of inflammatory responses, but exact mechanism not understood. Here we showed that induces apoptosis and pyroptosis in normal or precancerous human bronchial cells. Apoptosis was induced only malignant tumor cells infected with virus. In respiratory (PL16T), number apoptotic increased at early phases infection, pyroptotic were observed late infection. These findings suggest pathway...
MxA inflammasome restricts influenza A virus infection in respiratory epithelium.
Alzheimer’s disease (AD) is a form of dementia characterized by progressive memory decline and cognitive dysfunction. With only one FDA-approved therapy, effective treatment strategies for AD are urgently needed. In this study, we found that microRNA-485-3p (miR-485-3p) was overexpressed in the brain tissues, cerebrospinal fluid, plasma patients with AD, its antisense oligonucleotide (ASO) reduced Aβ plaque accumulation, tau pathology development, neuroinflammation, transgenic mouse model...
Programmed cell death (PCD) is essential for the innate immune response, which serves as first line of defense against pathogens. Caspases regulate PCD, responses, and homeostasis. Caspase-8 specifically plays multifaceted roles in PCD pathways including pyroptosis, apoptosis, necroptosis. However, because caspase-8-deficient mice are embryonically lethal, little known about how caspase-8 coordinates different under physiological conditions. Here, we report an anti-inflammatory role during...
Type I interferons (IFNs) are essential innate immune proteins that maintain tissue homeostasis through tonic expression and can be upregulated to drive antiviral resistance inflammation upon stimulation. However, the mechanisms inhibit aberrant IFN upregulation in impacts of production on health disease remain enigmatic. Here, we report caspase-8 negatively regulates type by inhibiting RIPK1-TBK1 axis during across multiple cell types tissues. When is deleted or inhibited, RIPK1 interacts...
Hantavirus cardiopulmonary syndrome (HCPS), which is caused by infection with Choclo virus, uncommon in Panama, yet seropositivity among rural residents as high 60%. To clarify the environmental risk factors favoring rodent-to-human transmission, we tested serum from 3,067 rodents captured over a five-year period for antibodies against recombinant N protein of hantavirus enzyme immunoassay and strip immunoblot. Among 220 seropositive rodents, Oligoryzomys fulvescens, reservoir had highest...
Asthma is a chronic inflammatory disease of the airways associated with excess production Th2 cytokines and lung eosinophil accumulation. This response persists in spite steroid administration that blocks autocrine/paracrine loops cytokines, detailed mechanisms underlying asthma exacerbation remain unclear. Here, we show triggered by airway macrophages through prion-like cell-to-cell transmission extracellular particulates, including ASC protein, assemble inflammasomes mediate IL-1β...
Abstract During 2001–2007, to determine incidence of all hantavirus infections, including those without pulmonary syndrome, in western Panama, we conducted 11 communitywide surveys. Among 1,129 persons, antibody prevalence was 16.5%–60.4%. Repeat surveys 476 found that patients who seroconverted outnumbered with syndrome by 14 1.
Lentinula edodes mycelia (LEM) solid culture extracts contain many bioactive compounds with diverse pharmacological activities such as antitumor, antiviral, and immunopotentiating effects. In this study, we examined the anti-influenza virus activity of LEM in vitro vivo. directly inhibited influenza growth at early phases infection, possibly entry process viral particles to host cells. We also found that nasal administration increased survival rate infected mice, was likely due direct action...