A5005282042- 14-3-3 protein interactions
- Voice and Speech Disorders
- Ubiquitin and proteasome pathways
- Phonetics and Phonology Research
- Plasma Applications and Diagnostics
- Plant Disease Resistance and Genetics
- Dysphagia Assessment and Management
- Epigenetics and DNA Methylation
- Microplastics and Plastic Pollution
- Microbial Natural Products and Biosynthesis
- RNA modifications and cancer
- Surface Modification and Superhydrophobicity
- Electrospun Nanofibers in Biomedical Applications
- Plasma Diagnostics and Applications
- Stuttering Research and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Single-cell and spatial transcriptomics
- Electrohydrodynamics and Fluid Dynamics
- Cancer-related gene regulation
- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
- Enzyme-mediated dye degradation
- Adipose Tissue and Metabolism
- Biosensors and Analytical Detection
Hanyang University
2021-2025
Florida State University
2022-2025
Ulsan National Institute of Science and Technology
2024-2025
Convergence
2025
University of Tsukuba
2015-2023
St. Jude Children's Research Hospital
2022
University of North Carolina at Chapel Hill
2014-2021
Yonsei University
2008-2020
University of Ulsan
2020
Asan Medical Center
2020
Genes implicated in neuropsychiatric disorders are active human fetal brain, yet difficult to study a longitudinal fashion. We demonstrate that organoids from pluripotent cells model cerebral cortical development on the molecular level before 16 weeks postconception. A multiomics analysis revealed differentially genes and enhancers, with greatest changes occurring at transition stem progenitors. Networks of converging gene enhancer modules were assembled into six four global patterns...
Purpose This study examined acoustic predictors of speech intelligibility in speakers with several types dysarthria secondary to different diseases and conducted classification analysis solely by measures according 3 variables (disease, severity, type). Method Speech recordings from 107 due Parkinson’s disease, stroke, traumatic brain injury, multiple system atrophy were used for perceptual judgment intelligibility. Acoustic included 8 segmental/suprasegmental features: 2nd formant frequency...
<i>Objective:</i> This study investigated the distribution of second-formant (F2) slopes in a relatively large number speakers with dysarthria associated two different underlying diseases. <i>Patients and Methods:</i> Forty (20 Parkinson’s disease, PD; 20 stroke) 5 control without history neurological disease were asked to repeat six words <i>(coat, hail, sigh, shoot, row</i> <i>wax</i>) 10 times. Acoustic analysis was performed derive F2...
Adenocarcinoma in situ (AIS) of the lung has an extremely favorable prognosis. However, early but invasive adenocarcinoma (eIA) sometimes a fatal outcome. We had previously compared expression profiles AIS with those eIA showing lymph node metastasis or outcome, and found that stratifin (SFN, 14-3-3 sigma) was differentially expressed gene related to cell proliferation. Here, we performed vivo study clarify role SFN initiation progression adenocarcinoma. Suppression A549 (a human line) by...
Purpose: The research aims of this study are to determine whether listening effort, as measured by pupil dilation and perceived effort (PLE) ratings, depends on the speech is produced a speaker with dysarthria versus neurotypical speaker, listener successfully spoken phrase.Method: Thirty-four listeners completed perception task while an eye-tracking camera tracked their dilation. Phrases in were secondary amyotrophic lateral sclerosis (ALS) speaker. After hearing each phrase, repeated what...
Purpose: This study examined how wearing electromagnetic articulography (EMA) sensors affects acoustic and perceptual speech outcomes in people with Parkinson’s disease (PwPD) dysarthria neurologically healthy control speakers. Additionally, the explored potential after-effects on measures following approximately 45 minutes of EMA both groups. Finally, we investigated whether or after-sensor effects differentially impacted two groups.Methods: Thirty-four speakers (21 Controls 13 PwPD) read...
Lung cancer remains one of the most lethal cancers globally, with nonsmall cell lung (NSCLC) representing predominant subtype. Despite significant advancements in targeted therapies, overcoming therapeutic resistance NSCLC a challenge, particularly cases resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). Here, we developed target-specific, protein nanoparticles using Aquifex aeolicus...
A plasma pad that can be attached to human skin was developed for aesthetic and dermatological treatment. polyimide film used the dielectric layer of flexible pad, high-voltage ground electrodes were placed on surface. Medical gauze covered facing act as a spacer; thus, floated between electrodes. In vitro in vivo biocompatibility tests showed no cytotoxicity normal cells irritation mouse skin. Antibacterial activity shown against Staphylococcus aureus clinical isolates methicillin-resistant...
This study examined the reliability and validity of speech-language pathologists' (SLP) estimations speech intelligibility in dysarthria, including a visual analog scale (VAS) method percent estimation commonly used clinical settings. Speech samples from 20 speakers with dysarthria varying etiologies were to collect orthographic transcriptions naïve listeners n=70 VAS ratings SLPs n=21. Intra- interrater for two SLP measures evaluated, relationship between these was assessed. Finally, linear...
The aim of this study was to investigate a possible link between high-fat diet (HFD)-induced obesity and the expression protein phosphatase 2A (PP2A) Cdc42-interacting 4 (CIP4) proteins, potential downstream components IRS/PI3K/AKT CAP/Cbl/TC10 pathway, respectively, in visceral adipose tissue.Twenty male Sprague-Dawley rats were randomly divided into two groups given either HFD or normal (ND) for 8 weeks. HFD-induced changes epididymal tissue genes involved insulin-signaling pathways...
Alterations of epidermal growth factor receptor (EGFR) expression frequently occur in early‐stage lung adenocarcinoma. Ubiquitin‐specific protease 8 (USP8) has been reported to stabilize EGFR protein at the plasma membrane through recycling pathway. Here, we examined correlation between USP8 and or mutation status EGFR, as well clinicopathological features adenocarcinoma patient outcome. Expression surgically resected specimens (82 cases) was by immunohistochemistry. Overexpression mutually...
// Ryan Edbert Husni 1 , Aya Shiba-Ishii 2 Tomoki Nakagawa Tomoko Dai Yunjung Kim Jeongmin Hong Shingo Sakashita Noriaki Sakamoto Yukio Sato 3 and Masayuki Noguchi Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human University Tsukuba, Ibaraki, Japan Department Diagnostic Pathology, Faculty Medicine, Thoracic Surgery, Correspondence to: Shiba-Ishii, email: aya_shiba@md.tsukuba.ac.jp Keywords: epigenetics; DNA demethylation; early-stage lung adenocarcinoma;...
Purpose: This study aimed to investigate the perceptual, acoustic, and kinematic differences between speakers with without dysarthria due Parkinson’s disease (PD) across conversational, less clear, more clear clarity conditions.Methods: Forty participants, including 22 PD 18 controls, read three phrases aloud using speaking conditions. Acoustic measures were obtained from diphthong /aɪ/ selected vowels in sentences. A total of 368 listeners crowdsourcing provided ratings for intelligibility...
Regulators of G-protein Signaling (Rgs) proteins are the members a multigene family GTPase-accelerating (GAP) for Galpha subunit heterotrimeric G-proteins. Rgs play critical roles in regulation G protein couple receptor (GPCR) signaling normal physiology and human diseases such as cancer, heart diseases, inflammation. Rgs12 is largest family. Some vitro studies have demonstrated that plays role regulating cell differentiation migration; however its function mechanism vivo largely unknown....
Immunoglobulin ( CD 79a) binding protein 1 IGBP 1) is universally overexpressed in lung adenocarcinoma and exerts an anti‐apoptotic effect by to PP 2Ac. However, the molecular mechanism of overexpression still unclear. In present study, we used a micro RNA (mi ) array TargetScan Human software detect 1‐related mi s that regulate expression. The analysis revealed more than 100 are dysregulated early invasive adenocarcinoma. On other hand, silico using 79 associated with Among selected...
Abstract Purpose: Aberrant overexpression of SFN (stratifin) plays an oncogenic role in lung adenocarcinoma. We have shown previously that SKP1, adapter component E3 ubiquitin ligase forming SCF complex, is a unique SFN-binding protein adenocarcinoma cells. Experimental Design: In silico simulation and vitro mutagenesis analysis were performed to identify the domain on SKP1. examined expression, localization, stability SKP1 after knockdown using cells including A549. library screening...