Shane Fernandez
A5068691630- Genetic Associations and Epidemiology
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Advanced Neuroimaging Techniques and Applications
- Bioinformatics and Genomic Networks
- Cardiovascular Health and Disease Prevention
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Cancer-related gene regulation
- Neurological Disease Mechanisms and Treatments
- Genetic Syndromes and Imprinting
- Advanced MRI Techniques and Applications
- Diabetes and associated disorders
Edith Cowan University
2017-2024
Australian Alzheimer’s Research Foundation
2021
Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer's disease (LOAD). However, LOAD genetic architecture and prediction are unclear. Here we estimate the optimal P-threshold (P
Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it unknown whether continuous age- AD-related cortical degradation alters asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order regions exhibiting pronounced at age ~20 also asymmetry-loss across lifespan. Hence, accelerated thinning (previously) thicker homotopic hemisphere a aging. This...
Abstract Alzheimer’s Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles tau protein. As no current clinical test can diagnose individuals at risk developing AD, aim this project to evaluate a blood-based biomarker panel identify who carry risk. We analysed levels 22 biomarkers in clinically classified healthy controls (HC), mild cognitive impairment (MCI) participants from well Australian...
Abstract Epigenome-wide association studies (EWAS) are susceptible to widespread confounding caused by population structure and genetic relatedness. Nevertheless, kinship estimation is challenging in EWAS without genotyping data. Here, we proposed MethylGenotyper, a method that for the first time enables accurate at thousands of single nucleotide polymorphisms (SNPs) directly from commercial DNA methylation microarrays. We modeled intensities probes near SNPs with mixture three beta...
Abstract. Background: Genetic variation in Spondin-1, specifically rs11023139, has been associated with reduced rates of cognitive decline individuals Alzheimer’s disease. Objective: The aim this study was to assess whether the association present cognitively normal older adults. Methods: Longitudinal investigated using linear mixed modelling a cohort 590 adults enrolled Australian Imaging, Biomarkers and Lifestyle Study. Results: No independent effect Spondin-1 rs11023139 on observed....
Abstract Epigenome-wide association studies (EWAS) are susceptible to widespread confounding caused by population structure and genetic relatedness. Nevertheless, kinship estimation is challenging in EWAS without genotyping data. We propose MethylGenotyper, a method that for the first time enables accurate at thousands of SNPs directly from commercial DNA methylation microarrays. model intensities probes near with mixture three beta distributions corresponding different genotypes estimate...
Abstract Background Genome‐wide association studies (GWAS) have identified numerous genetic variants associated with Alzheimer’s disease (AD) risk, but variation in the onset and progression of AD pathology is less understood. Accumulation amyloid‐β (Aβ) brain a key pathological hallmark beginning 10 – 20 years prior to cognitive symptoms. We investigated basis age at (AAO) Aβ by comparing performance polygenic scores (PGSs) based on risk resilience Aβ‐AAO trait‐specific PGS. Method 1122...
Abstract Background World‐Wide FINGERS (WW‐FINGERS) is a global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention (Kivipelto et al., 2020). With over 30 countries conducting studies within the network, harmonizing interventions data collection wherever possible priority. However, study‐specific adaptations are inevitable to accommodate differences in language, culture, environment. Thus, single system not feasible across WW‐FINGERS opportunities...