A5074869182- Glycosylation and Glycoproteins Research
- Diabetes and associated disorders
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Adipokines, Inflammation, and Metabolic Diseases
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Genetic Associations and Epidemiology
- Advanced Neuroimaging Techniques and Applications
- Carbohydrate Chemistry and Synthesis
- Cardiovascular Health and Risk Factors
- Cynara cardunculus studies
- Epigenetics and DNA Methylation
- Muscle Physiology and Disorders
- Metabolomics and Mass Spectrometry Studies
- Motor Control and Adaptation
- Regulation of Appetite and Obesity
- Lipoproteins and Cardiovascular Health
- Genomics and Phylogenetic Studies
- Plant Growth Enhancement Techniques
- Sports Performance and Training
- Neurological Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Sport Psychology and Performance
Murdoch University
2024
Edith Cowan University
2013-2022
Sheffield Hallam University
2022
University of Calgary
2020
The University of Western Australia
2018-2019
Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer's disease (LOAD). However, LOAD genetic architecture and prediction are unclear. Here we estimate the optimal P-threshold (P
Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it unknown whether continuous age- AD-related cortical degradation alters asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order regions exhibiting pronounced at age ~20 also asymmetry-loss across lifespan. Hence, accelerated thinning (previously) thicker homotopic hemisphere a aging. This...
The use of the emerging “omics” technologies for large scale population screening is promising in terms predictive, preventive and personalized medicine. For Parkinson's disease, it essential that an accurate diagnosis obtained disease progression can be monitored. Immunoglobulin G (IgG) has ability to exert both anti-inflammatory pro-inflammatory effects, N-glycosylation fragment crystallizable portion IgG involved this process. This study aimed determine whether glycome could a candidate...
Type 2 diabetes mellitus (T2DM) is a common complex trait arising from interactions among multiple environmental, genomic, and postgenomic factors. We report here the first attempt to investigate association between immunoglobulin G (IgG) N-glycan patterns, T2DM, their clinical risk factors in an Australian population. N-glycosylation of proteins one most frequently observed co- post-translational modifications, reflecting, importantly, real-time status interplay genomic In community-based...
Despite decades of investment in biomarker research, we still do not have robust and field-tested biomarkers for many chronic diseases so as to anticipate clinical outcomes thus move toward personalized medicine. Biomarker innovations tended focus on genomics, but next-generation from the nascent field glycomics now offer fresh vistas innovation disease systems diagnostics. Glycosylation, regarded a complex enzymatic process where sugars (glycans) bind proteins lipids, affects human...
Aim: The study sought to apply N-glycosylation profiles understand the interplay between suboptimal health status (SHS) and metabolic syndrome (MetS). Materials & methods: In this study, 262 Ghanaians were recruited from May July 2016. After completing a survey, plasma samples collected for clinical assessments while ultra performance liquid chromatography was used measure N-glycans. Results: Four glycan peaks found predict case (MetS SHS) using step-wise Akaike's information criterion...
We report the recruitment activities and outcomes of a multi-disease neuromuscular patient registry in Canada. The Canadian Neuromuscular Disease Registry (CNDR) registers individuals across Canada with confirmed diagnosis disease. Diagnosis contact information are collected all diseases detailed prospective data is for 5 specific diseases: Amyotrophic Lateral Sclerosis (ALS), Duchenne Muscular Dystrophy (DMD), Myotonic (DM), Limb Girdle (LGMD), Spinal Atrophy (SMA). Since 2010, CNDR has...
Improving groundstroke velocity and accuracy is critical for tennis success. However, there limited research available on the physical cognitive attributes required performance. Therefore, purpose of this study was to investigate characteristics their association with performance in junior players. Thirty-four competitive players, aged 12.59 ± 2.44 years, participated cross-sectional study. Cognitive tests assessing processing speed, complex attention, flexibility problem-solving capacity...
Inulin, a polysaccharide characterized by β-2,1 fructosyl-fructose structure terminating in glucosyl moiety, is naturally present plant roots and tubers. Current methods provide average degrees of polymerization (DP) but lack information on the distribution absolute concentration each DP. To address this limitation, reproducible (CV < 10 %) high throughput (<2 min/sample) MALDI-MRMS approach capable characterizing quantifying inulin molecules plants using matched-matrix consisting...
It is critical to distinguish events that are temporarily associated with, but not caused by, vaccination from those by during mass immunization. We performed a literature search in China National Knowledge Infrastructure and Pubmed databases. The number of coincident was calculated based on its incidence rate periods after receipt dose hypothesized vaccine. included background incidences Guillain-Barré syndrome, anaphylaxis, seizure, sudden adult death cardiac death, spontaneous abortion,...
Aim: The study sought to determine the patterns of N-glycan profiles among Type 2 diabetes mellitus (T2DM) patients over a 6-month period. Materials & methods: Biochemical and clinical data were obtained from 253 T2DM at baseline follow-up. Ultra-performance liquid chromatography statistical methods applied for profiling. Results: coefficients variation 28% 29% follow-up, respectively, whereas range variability was 11% 56%. Apart GP1 (FA2) GP29 (FA3G3S [3,3,3]3), intra-individual variations...