A5070227264- Parkinson's Disease Mechanisms and Treatments
- Pluripotent Stem Cells Research
- Neurological disorders and treatments
- Neurogenesis and neuroplasticity mechanisms
- Autism Spectrum Disorder Research
- Developmental Biology and Gene Regulation
- Hedgehog Signaling Pathway Studies
- MicroRNA in disease regulation
- Nuclear Receptors and Signaling
- Axon Guidance and Neuronal Signaling
- Restless Legs Syndrome Research
- Nerve injury and regeneration
- Dementia and Cognitive Impairment Research
- Monoclonal and Polyclonal Antibodies Research
- Sleep and related disorders
- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Sleep and Wakefulness Research
- Olfactory and Sensory Function Studies
- Congenital heart defects research
- Brain Tumor Detection and Classification
- Genetic and rare skin diseases.
- Hippo pathway signaling and YAP/TAZ
- Congenital limb and hand anomalies
- Migration, Aging, and Tourism Studies
Edith Cowan University
2009-2019
The University of Western Australia
2006-2018
Curtin University
2016
Speech Pathology Australia
2016
Bridge University
2016
Wicking Dementia Centre
2009
Zero to Three
2008
Baylor College of Medicine
2004
St Mary's Hospital
1994
St. Mary's Hospital
1994
The benefits of physical exercise for psychological aspects quality life (QoL) are well established in normally ageing adults, yet potential people with Parkinson's disease (PD) have received limited attention. This study evaluated the cognitive functioning, mood and disease-specific QoL PD.Twenty-eight individuals PD were allocated to an intervention program (EIP, n = 15) or control group (n 13). EIP undertook a programme progressive anabolic aerobic twice weekly 12 weeks. maintained their...
The use of the emerging “omics” technologies for large scale population screening is promising in terms predictive, preventive and personalized medicine. For Parkinson's disease, it essential that an accurate diagnosis obtained disease progression can be monitored. Immunoglobulin G (IgG) has ability to exert both anti-inflammatory pro-inflammatory effects, N-glycosylation fragment crystallizable portion IgG involved this process. This study aimed determine whether glycome could a candidate...
This study investigated the predictive value of various coping processes for psychological and disease specific aspects health-related quality life (HRQoL) in Parkinson's (PD).Cross-sectional 85 participants with PD using Ways Coping Questionnaire (WCQ), Depression, Anxiety, Stress Scale (DASS-21), (PDQ-39), socio-demographic clinical variables.Greater use planful problem solving was found to be significantly associated better HRQoL relation cognitive impairment, communication bodily...
Summary The caudal zona incerta is the target of a recent modification established procedures for deep brain stimulation ( DBS ) Parkinson's disease and tremor. contains number neuronal populations that are distinct in terms their cytoarchitecture, connections, pattern immunomarkers located at position where major tracts converge before turning toward final destination forebrain. However, it not clear which anatomical features region related to its value as . This paper has tried identify...
Personality traits influence health-related quality of life (HRQoL) in Parkinson's disease (PD). Further, an individual's personality can the strategies they use to cope with a particular stressful situation. However, PD, interplay between traits, choice coping strategy, and their subsequent effect on HRQoL remains unclear.The objective this study was examine whether (neuroticism extraversion) indirectly affects through specific psychological strategies.One hundred forty-six patients PD...
The paired box gene 6 (PAX6) is a powerful mediator of eye and brain organogenesis whose spatiotemporal expression exquisitely controlled by multiple mechanisms, including post-transcriptional regulation microRNAs (miRNAs). In the present study, we use bioinformatic predictions to identify three candidate microRNA-7 (miR-7) target sites in human PAX6 3' untranslated region (3'-UTR) demonstrate that two them are functionally active cell line. Furthermore, transient transfection cells with...
Abstract A Movement Disorder Society (MDS) taskforce recently proposed diagnostic criteria for Parkinson’s disease with features of mild cognitive impairment (PD-MCI). This study first examined the prevalence and nature PD-MCI in a non-demented cohort using MDS criteria. Using generic Monte Carlo simulation method developed by Crawford colleagues (2007), this then estimated base rate representative population who would demonstrate due to chance alone. total 104 participants idiopathic PD...
The transcription factor Pax6 is a well-accepted neurogenic determinant during development, in adult neural progenitor cells and acute brain injury models. In the expressed selective populations of dopaminergic neurons, thus may have role to play Parkinson's disease (PD). This study looked at post-mortem tissue from patients with PD particular substantia nigra which showed reduced number PAX6+ compared age sex matched control tissue. an animal model PD, there was early transient increase SN...
Parkinson's disease is a progressive neurodegenerative disorder associated with reduced spatial and verbal working memory ability. There are two established motor subtypes of PD, tremor dominant (TD) postural instability gait difficulty (PIGD). This study used structural equation modelling to explore the longitudinal relationship between assessed at 2-year follow-up. The comprised 84 males 30 females (N = 114), aged 39 85 (M 64.82, SD 9.23) confirmed PD. was no significant subtype Time 1 2....
The Depression, Anxiety, and Stress Scale -21 (DASS-21) is a frequently used measure of emotional disturbance symptoms in Parkinson's disease (PD). However, the factor structure DASS-21 PD has yet to be explored.To assess whether scale measuring these same way as general population.The present study fit series established structures with both confirmatory analysis (CFA) exploratory structural equation modelling (ESEM) using data from 251 participants PD.The 3-factor ESEM provided best fit....
The Ways of Coping Questionnaire (WCQ) is used extensively in health research, but the measurement properties and suitability WCQ for people with Parkinson’s disease (PD) have not been psychometrically assessed. If does align its original 8-factor structure a PD population, use subscales may be appropriate. present study confirmatory factor analysis (CFA), exploratory (EFA), multiple-group EFA to determine ideal sample. 8 factors were reproduced. revealed 6-factor structure, including...
The transcription factor Pax7 has been implicated in the normal development of superior colliculus and continues to be expressed adult colliculus, where it is concentrated retino-recipient laminae. Here we assessed, immunohistochemically, expression rat after unilateral intraorbital optic nerve transection. We show that transection, number Pax7-expressing cells increased re-establish developmental rostral-caudal gradient these were neurons. These findings may have implications for design...
Many studies have sought to describe the relationship between sleep disturbance and cognition in Parkinson's disease (PD). The Disease Sleep Scale (PDSS) its variants (the Scale-Revised; PDSS-R, Scale-2; PDSS-2) quantify a range of symptoms impacting only 15 items. However, data from these scales may be problematic as included items considerable conceptual breadth, there overlap constructs assessed. Multidimensional measurement models, accounting for tendency measure multiple constructs,...