Laura McAdam
A5008206836- Muscle Physiology and Disorders
- Neurogenetic and Muscular Disorders Research
- Cerebral Palsy and Movement Disorders
- Children's Physical and Motor Development
- Cardiomyopathy and Myosin Studies
- Respiratory Support and Mechanisms
- Family and Disability Support Research
- Adolescent and Pediatric Healthcare
- Child Nutrition and Feeding Issues
- Fibromyalgia and Chronic Fatigue Syndrome Research
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Anomalies and Fetal Surgery
- Bone fractures and treatments
- Neonatal Respiratory Health Research
- Cardiovascular Effects of Exercise
- Eating Disorders and Behaviors
- Exercise and Physiological Responses
- Vitamin D Research Studies
- Anesthesia and Neurotoxicity Research
- Muscle activation and electromyography studies
- Traumatic Brain Injury Research
- Autism Spectrum Disorder Research
- Trauma and Emergency Care Studies
Holland Bloorview Kids Rehabilitation Hospital
2015-2024
University of Toronto
2015-2024
Hospital for Sick Children
2012-2020
SickKids Foundation
2016-2020
Children's National
2015-2018
George Washington University
2015-2018
University of California Davis Medical Center
2015-2016
University of Padua
2016
University Hospital Cologne
2016
University of Cologne
2016
Duchenne muscular dystrophy is a progressive neuromuscular condition that has high rate of cognitive and learning disabilities as well neurobehavioral disorders, some which have been associated with disruption dystrophin isoforms. Retrospective cohort 59 boys investigated the profile dystrophy. Full-scale IQ < 70 was seen in 27%; disability 44%, intellectual 19%; attention-deficit/hyperactivity disorder 32%; autism spectrum disorders 15%; anxiety 27%. Mutations affecting Dp260 isoform...
We aimed to perform an observational study of age at loss independent ambulation (LoA) and side-effect profiles associated with different glucocorticoid corticosteroid (GC) regimens in Duchenne muscular dystrophy (DMD).We studied 340 participants the Cooperative International Neuromuscular Research Group Natural History Study (CINRG-DNHS). LoA was defined as continuous wheelchair use. Effects prednisone or prednisolone (PRED)/deflazacort (DFZ), administration frequency, dose were analyzed by...
<h3>Objective:</h3> To correlate time to loss of ambulation (LoA) and different truncating <i>DMD</i> gene mutations in a large, prospective natural history study Duchenne muscular dystrophy (DMD), with particular attention amenable emerging molecular treatments. <h3>Methods:</h3> We analyzed data from the Cooperative International Neuromuscular Research Group Natural History Study for participants single- or multi-exon deletions duplications defined exon boundaries (n = 186), small...
Background: Duchenne muscular dystrophy, a progressive muscle disorder that occurs in males, causes gradual decline strength. This is associated with the development of scoliosis. Previous studies have shown use glucocorticoids slows progression scoliosis, but it unknown if spine remains straight long term. We examined glucocorticoid treatment has long-term effect on prevalence Methods: Fifty-four boys who had been diagnosed dystrophy while they were still walking enrolled non-randomized...
We describe changes in pulmonary function measures across time Duchenne muscular dystrophy patients treated with glucocorticoids (GCs) > 1 year compared to GC naïve the Cooperative International Research Group Natural History Study, a multicenter prospective cohort study. 397 participants underwent 2799 assessments over period up 10 years. Fifty-three (< month exposure) were 322 subjects cumulative treatment. Forced vital capacity (FVC), peak expiratory flow rate (PEFr), maximal inspiratory...
Abstract Duchenne muscular dystrophy (DMD) is characterized by muscle degeneration and progressive weakness. There considerable inter-patient variability in disease onset progression, which can confound the results of clinical trials. Here we show that a common null polymorphism (R577X) ACTN3 significantly reduced strength longer 10 m walk test time young, ambulant patients with DMD; both are primary outcome measures We have developed double knockout mouse model, also shows strength, but...
Purpose: To evaluate the feasibility and acceptability of a coaching intervention (Solution-Focused Coaching in pediatric rehabilitation [SFC-Peds]) related to physical activity diet males with Duchenne muscular dystrophy. Methods: A pre-post design was employed. Participants had five sessions over 8 weeks. The first session face-to-face, followed by four virtual sessions. Feasibility criteria included recruitment rates, attrition, fidelity. Canadian Occupational Performance Measure (COPM)...
Impaired cough results in airway secretion retention, atelectasis and pneumonia individuals with Duchenne muscular dystrophy (DMD). Lung volume recruitment (LVR) stacks breaths to inflate the lungs greater volumes than spontaneous effort. LVR is recommended DMD clinical care guidelines but not well studied. We aimed determine whether twice-daily LVR, compared standard of alone, attenuates decline FVC at 2 years boys DMD.
Abstract Background Most research into clinical care of Duchenne or Becker dystrophinopathies (MD) has focused on slowing progressive muscular weakness and extending lifespan. Scarce attention been paid to the “human” aspects such as psychosocial health, living a fulfilling life, dealing with disability stigma. This study partnered clinicians identify address local systemic barriers these human care. Methods We employed participatory qualitative design at multidisciplinary MD clinic using 2...
We report the recruitment activities and outcomes of a multi-disease neuromuscular patient registry in Canada. The Canadian Neuromuscular Disease Registry (CNDR) registers individuals across Canada with confirmed diagnosis disease. Diagnosis contact information are collected all diseases detailed prospective data is for 5 specific diseases: Amyotrophic Lateral Sclerosis (ALS), Duchenne Muscular Dystrophy (DMD), Myotonic (DM), Limb Girdle (LGMD), Spinal Atrophy (SMA). Since 2010, CNDR has...