A5017475778- Muscle Physiology and Disorders
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Genetic Neurodegenerative Diseases
- Thallium and Germanium Studies
- Neurogenetic and Muscular Disorders Research
- Healthcare cost, quality, practices
- Thyroid Cancer Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- COVID-19 and healthcare impacts
- Oral health in cancer treatment
- Coenzyme Q10 studies and effects
- Knee injuries and reconstruction techniques
- Metabolism and Genetic Disorders
- Hair Growth and Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Coordination Chemistry and Organometallics
- Pharmacological Effects and Toxicity Studies
- Boron Compounds in Chemistry
- Health Systems, Economic Evaluations, Quality of Life
- Pneumothorax, Barotrauma, Emphysema
- Cardiac Imaging and Diagnostics
- Protein Degradation and Inhibitors
- Healthcare Systems and Challenges
- Takotsubo Cardiomyopathy and Associated Phenomena
Ospedale Papa Giovanni XXIII
2022-2024
Italfarmaco (Italy)
2016-2024
Janssen (Italy)
2020
Società Italiana di Medicina Generale
2020
Ibero American University
2019
University of Milano-Bicocca
2005-2018
Ospedale San Paolo
2016
University of Milan
2016
Fondazione IRCCS Istituto Nazionale dei Tumori
1996
<h3>Objectives</h3> To compare the effects of an intermediate molecular weight (MW) intra-articular hyaluronic acid (HA) with a low MW product on knee osteoarthritis (OA) symptoms. <h3>Methods</h3> Patients symptomatic OA were enrolled inarandomised, controlled, double-blind, parallel-group, non-inferiority trial possibility to shift superiority. randomised GO-ON(MW 800–1500 kD, 25 mg/2.5 ml) or Hyalgan(MW 500–730 20 mg/2 injected at 3-weekly intervals. The primary outcome was 6-month change...
Abstract Becker muscular dystrophy (BMD) is a severe X-linked muscle disease. Age of onset, clinical variability, speed progression and affected tissues display wide making trial design for drug development very complex. The histopathological changes in skeletal tissue are central to the pathogenesis, but they have not been thoroughly elucidated yet. Here we analysed biopsies from large cohort BMD patients, focusing our attention on parameters, as fibrosis, fatty replacement, fibre cross...
No treatments are approved for Becker muscular dystrophy (BMD). This study investigated the efficacy and safety of givinostat, a histone deacetylase pan-inhibitor, in adults with BMD.Males aged 18-65 years diagnosis BMD confirmed by genetic testing were randomized 2:1 to 12 months treatment givinostat or placebo. The primary objective was demonstrate statistical superiority over placebo mean change from baseline total fibrosis after months. Secondary endpoints included other histological...
Thyroid neoplasia is frequently associated with rearranged during transfection (RET) proto-oncogene mutations that cause hyperactivation of RET kinase activity. Selective inhibition RET-mediated signaling should lead to an efficacious therapy. SU5416 a potent inhibitor vascular endothelial cell growth factor receptor, c-Kit, and FLT-3 receptor tyrosine kinases presently used in clinical trials. We found inhibits similar potency, both cell-free assays cells, thus causing proliferation arrest...
During amyotrophic lateral sclerosis progression, up to 85% of patients develop dysphagia. Riluzole oral suspension 50 mg/10 mL is bioequivalent riluzole 50-mg film-coated tablets administered orally under fasting conditions. Here, we compare the bioavailability a single dose via intragastric tube, proxy for percutaneous endoscopic gastrostomy administration, with that administration in healthy volunteers Secondary objectives included plasma pharmacokinetic and safety profiles each...
The coronavirus disease 2019 (COVID-19) pandemic has stressed the importance of health research as never before. In specific domain clinical research, effort to rapidly find responses challenges and therapeutic hypotheses highlighted need for efficient, timely, ethically correct research. guidelines published by Agenzia Italiana del Farmaco have shown that some useful changes are feasible: simple rapid methods been implemented conduct in emergency conditions pandemic, maintaining high levels...
Becker muscular dystrophy (BMD) is characterized by variable disease severity and progression, prompting the identification of biomarkers for clinical trials. We used data from an ongoing phase II study to provide a comprehensive characterization cohort patients with BMD, assess correlations between histological magnetic resonance imaging (MRI) markers muscle function strength.Eligible were ambulatory males aged 18 65 years (200 450 meters on 6-minute walk test). The following obtained: test...
BACKGROUND: Lombardy was the epicenter of first coronavirus disease 2019 (COVID-19) outbreak in western countries. The began February 2020 and rapidly disseminated throughout region. ICU beds were vastly insufficient clinical knowledge poor at that time. Unfortunately, data on long-term mortality, morbidity, Quality Life are scarce controversial. aim this study to evaluate 1-year survival, Life, functional recovery patients with COVID-19 admitted Intensive Care Units.METHODS: All invasively...
Background Givinostat (ITF2357), an oral, synthetic histone deacetylase inhibitor, significantly improved all histological muscle biopsy parameters in a Phase II study boys with Duchenne muscular dystrophy (DMD).Research Design and Methods A population pharmacokinetic (PK) model, including seven clinical studies, was developed to explore the effect of covariates on givinostat PK. The final model qualified simulate pediatric dosing recommendations. PK/pharmacodynamic (PD) link between plasma...
: Cancer is associated with a prothrombotic or hypercoagulable state. Intracoronary thrombosis rare and potentially life-threatening complication in cancer patients. We describe case of large nonocclusive intracoronary successfully treated by means medical therapy.
Becker muscular dystrophy (BMD) is an X-linked neuromuscular disorder due to mutation in the DMD gene, encoding dystrophin. Despite a wide clinical variability, BMD characterized by progressive muscle degeneration and proximal weakness. Interestingly, dysregulated expression of muscle-specific microRNAs (miRNAs), called myomirs, has been found patients affected with dystrophies, although few studies have conducted BMD. We analysed serum levels subset myomirs cohort 29 ambulant individuals...
Prone positioning is frequently used for non-intubated hypoxemic patients with COVID-19, although conclusive evidence still lacking. The aim of the present study was to investigate whether baseline CT-scans could predict improvement in oxygenation COVID-19 related Acute respira-tory syndrome (ARDS) when pronated.A retrospective who underwent non-invasive ventilation (NIV) and prone conducted.Forty-five were included. On average, 50% overall lung volume affected by disease, as observed...
Objective: To evaluate in a phase II study the safety and efficacy of Givinostat ambulant boys affected with Duchenne Muscular Dystrophy (DMD). Background: DMD is most common muscular dystrophy childhood. The only medication so far shown to be effective delaying progression this illness are corticosteroids. histone deacetylase inhibitor developed by Italfarmaco. In preclinical studies, it has been tested mdx mice showing significant reduction fibroadipose replacement muscle. Design/Methods:...