A5047106873- Neurogenetic and Muscular Disorders Research
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Tracheal and airway disorders
- Neuroscience of respiration and sleep
- Airway Management and Intubation Techniques
- Obstructive Sleep Apnea Research
- Cystic Fibrosis Research Advances
- Infant Development and Preterm Care
- Family and Patient Care in Intensive Care Units
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Family and Disability Support Research
- Energy Harvesting in Wireless Networks
- Congenital Anomalies and Fetal Surgery
- Childhood Cancer Survivors' Quality of Life
- RNA modifications and cancer
- Mechanical Circulatory Support Devices
- Respiratory and Cough-Related Research
- Congenital Heart Disease Studies
- Travel-related health issues
- Sleep and related disorders
- Esophageal and GI Pathology
- Child Nutrition and Feeding Issues
Hospital for Sick Children
2008-2024
University of Toronto
2015-2024
SickKids Foundation
2019-2024
Canada Research Chairs
2021-2023
Holland Bloorview Kids Rehabilitation Hospital
2017-2021
Northwestern University
2021
Great Ormond Street Hospital
2021
University College London
2021
University Health Network
2008
University of Manitoba
2008
For the clinician, diagnosis of arterial ischemic stroke (AIS) in children is a challenge. Prompt pediatric AIS within 6 hours enables stroke-specific thrombolytic and neuroprotective strategies.We conducted retrospective study prospectively enrolled consecutive cohort with AIS, admitted to The Hospital for Sick Children, Toronto, from January 1992 December 2004. data on clinical presentation, symptom onset, emergency department arrival, neuroimaging were recorded. putative predictors...
Several cases of parkinsonism were found in a ferromanganese smelter after the ventilation system had broken down and not been repaired for eight months 1985. To determine aetiology prevalence parkinsonism, 132 workers submitted to thorough medical examination estimated air concentrations carbon monoxide manganese at different worksites. Only six performing electrode fixation or welding during 1985 developed parkinsonism. They exposed 30 minutes each day, seven days week, high (greater than...
Over the last 30 to 40 years, improvements in technology, as well changing clinical practice regarding appropriateness of long-term ventilation patients with "non-curable" disorders, have resulted increasing numbers children surviving what were previously considered fatal conditions. This has come but at expense requiring ongoing, prolonged mechanical (both invasive and noninvasive). Although there are many publications pertaining specific aspects home (HMV) children, few comprehensive...
<h3>Background and Objectives</h3> The introduction of spinal muscular dystrophy (SMA)-modifying therapies, such as antisense oligonucleotide therapy, has changed the natural history SMA. Most reports on treatment outcomes have focused motor scores respiratory function. objective this study is to document development progression scoliosis in patients with SMA1 treated nusinersen. <h3>Methods</h3> A descriptive single-center was conducted who were nusinersen before 6 months age. Data...
Objective Spinal muscular atrophy (SMA) is a neuromuscular disorder that manifests with motor deterioration and respiratory complications. The paradigm of care shifting as disease-modifying therapies including nusinersen, onasemnogene abeparvovec risdiplam alter the disease trajectory SMA. objective this study was to explore caregivers’ experiences for Design Qualitative semistructured interviews caregivers children SMA who received therapies. Interviews were audio recorded, transcribed...
To describe the current clinical practice patterns of Canadian pediatric respirologists at tertiary care institutions regarding chronic tracheostomy tube and management home invasive ventilation.A respirologist/pediatrician with expertise in ventilation was identified each center to complete a 59-item survey multiple choice short answer questions. Domains assessed included care, caregiver competency monitoring, speaking valves, medical complications, decannulation, long-term follow-up.The...
Spinal muscular atrophy type 1 (SMA1) is a neuromuscular disorder with natural history of chronic respiratory failure and death during infancy without ventilation. Recently, disease-modifying therapies such as nusinersen have improved disease trajectory. However, objective data on the trajectory polysomnography outcomes, relationship between motor scores parameters, technology dependence healthcare utilization in children SMA1 remain to be elucidated.This was retrospective observational...
Abstract Objectives Discharging a child home on long‐term ventilation (LTV) via tracheostomy is complex and involves multiple healthcare providers across sectors. To date, there has been paucity of data with respect to the experiences families transitioning LTV. Our objective was explore perceptions family caregivers (FCs) who have completed newly developed LTV discharge pathway as they transitioned home. Methods We conducted 11 semi‐structured interviews FCs. Interviews focused FC's...
There has been increasing interest in utilizing volume assured pressure support (VAPS) modes of ventilation for children, which historically had only favored adult populations. In addition to patients with obesity hypoventilation syndrome, newer pediatric populations it recently prescribed include congenital central syndrome and children neuromuscular disease such as Duchenne muscular dystrophy spinal atrophy. Given its expanding use pediatrics, greater familiarity VAPS is essential...
This report describes the first known case of Mucopolysaccharidosis type IIIA presenting with respiratory symptoms and characteristic lung pathology. highlights under-recognized areas systemic involvement earlier modes presentation in lysosomal storage disorders as well importance investigating infants who have persistent tachypnea.
We co-developed a multi-component virtual care solution (TtLIVE) for the home mechanical ventilation (HMV) population using aTouchAway™ platform (Aetonix). The TtLIVE intervention includes (1) visits; (2) customizable plans; (3) clinical workflows that incorporate reminders, completion of symptom profiles, and tele-monitoring; (4) digitally secure communication via messaging, audio, video calls; (5) Resource library including print audiovisual material.Our primary objective is to evaluate...