A5066663693- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Obstructive Sleep Apnea Research
- Neurogenetic and Muscular Disorders Research
- Neuroscience of respiration and sleep
- Congenital Diaphragmatic Hernia Studies
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Vagus Nerve Stimulation Research
- Epilepsy research and treatment
- Lymphatic Disorders and Treatments
- Teratomas and Epidermoid Cysts
- Myasthenia Gravis and Thymoma
- Congenital Heart Disease Studies
- Muscle Physiology and Disorders
- Energy Harvesting in Wireless Networks
- Lymphatic System and Diseases
- Coronary Artery Anomalies
- Cerebrospinal fluid and hydrocephalus
- Frailty in Older Adults
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
Western University
2019-2024
London Health Sciences Centre
2021-2023
Children's Hospital of Western Ontario
2021-2023
In-Q-Tel
2022
Mayo Clinic
2021
Hospital for Sick Children
2019
McGill University
2007-2013
University of Ottawa
2011
Montreal Clinical Research Institute
2007
Université de Montréal
2007
To describe the current clinical practice patterns of Canadian pediatric respirologists at tertiary care institutions regarding chronic tracheostomy tube and management home invasive ventilation.A respirologist/pediatrician with expertise in ventilation was identified each center to complete a 59-item survey multiple choice short answer questions. Domains assessed included care, caregiver competency monitoring, speaking valves, medical complications, decannulation, long-term follow-up.The...
Obstructive sleep apnea (OSA) is characterized by partial or complete airway obstruction during sleep. Prevalence about 1.2%.[1][1] Adenotonsillar hypertrophy and obesity are common risk factors in healthy children.[2][2] The condition also more specific at-risk populations,
Abstract Murine Ly49 receptors, which are expressed mainly on NK and NKT cells, interact with MHC class I (MHC-I) molecules varying specificity. Differing reports of Ly49/MHC binding affinities may be affected by multiple factors, including cis versus trans competition species origin the MHC-I L chain (β2-microglobulin). To determine contribution each these Ly49G, Ly49I, Ly49O, Ly49V, Ly49Q receptors from 129 mouse strain were individually human 293T cells or cell lines MHC-I–deficient...
Chiari malformation type I (CM-I) involves the herniation of cerebellar tonsils through foramen magnum. CM-I is associated with both obstructive sleep apnea (OSA) and central (CSA) in children. The primary management symptomatic remains surgical decompression. There is, however, a paucity data evaluating efficacy decompression surgery on outcomes related to sleep-disordered breathing (SDB). objective this study was evaluate SDB outcomes, specifically need for respiratory support following...
Abstract Introduction Understanding real‐world profiles from neuromuscular databases is helpful for optimizing clinical care and planning research studies. The Canadian Neuromuscular Disease Registry (CNDR) has respiratory data a population of boys with Duchenne Muscular Dystrophy (DMD). Objectives To describe cross‐sectional national DMD dataset. explore the relationship between forced vital capacity percent predicted (FVC%) disease severity parameters: scoliosis, ambulation ventilation...
With the growing prevalence of obesity in pediatric population, reports its severe complications are increasing. Obesity hypoventilation syndrome is an uncommon disorder children with altered respiratory mechanics, sleep-disordered breathing, and impaired ventilatory responses leading to persistent hypercapnia. Presentation varied, may remain relatively asymptomatic until challenged a infection, when they present acute failure. increasing use genetic testing patients, our knowledge potential...
We co-developed a multi-component virtual care solution (TtLIVE) for the home mechanical ventilation (HMV) population using aTouchAway™ platform (Aetonix). The TtLIVE intervention includes (1) visits; (2) customizable plans; (3) clinical workflows that incorporate reminders, completion of symptom profiles, and tele-monitoring; (4) digitally secure communication via messaging, audio, video calls; (5) Resource library including print audiovisual material.Our primary objective is to evaluate...
[Voir la version anglaise de l'article ici: www.cmaj.ca/lookup/doi/10.1503/cmaj.230897][1] L'AOS est caractérisée par une obstruction partielle ou complète des voies respiratoires pendant le sommeil. Sa prévalence d'environ 1,2 %[1][2]. Chez les enfants en bonne santé, l'
Plastic bronchitis (PB) is a rare disease characterized by the expectoration of amorphous, rubbery, cohesive, and branched bronchial casts that obstruct airway [1]. Bronchial are two types: Type 1 (inflammatory), 2 (acellular). [2] Most pediatric PB cases occur after correction congenital heart lesions, present with acellular [3]. has also been reported in patients viral infections presenting inflammatory To our knowledge there no associated COVID-19 infections. Our Case Report describes...