A5011900778- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Cardiovascular Health and Risk Factors
- Diabetes and associated disorders
- Nutritional Studies and Diet
- Mobile Health and mHealth Applications
- Immune Cell Function and Interaction
- Dementia and Cognitive Impairment Research
- SARS-CoV-2 and COVID-19 Research
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Clinical Research Studies
- Health, Environment, Cognitive Aging
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Health disparities and outcomes
- Genetic Associations and Epidemiology
- Advanced Proteomics Techniques and Applications
- Atherosclerosis and Cardiovascular Diseases
- MicroRNA in disease regulation
- Carbohydrate Chemistry and Synthesis
- Regulation of Appetite and Obesity
- Nutrition, Genetics, and Disease
- Metabolomics and Mass Spectrometry Studies
- Diet, Metabolism, and Disease
Edith Cowan University
2018-2025
Capital Medical University
2016-2025
Second Affiliated Hospital of Shantou University Medical College
2024
Shantou University
2024
Dalian Ocean University
2024
China Jiliang University
2019
Zhejiang Medicine (China)
2019
Capital University
2012
Chinese Academy of Sciences
2008-2011
As an important post-translation modifying process, glycosylation significantly affects the structure and function of immunoglobulin G (IgG) molecules is essential in many steps inflammatory cascade. Studies have demonstrated potential using features IgG as a component predictive biomarkers for chronological age several European populations, whereas no study has been reported Chinese. Herein, we report various patterns changes associated with by analyzing 701 community-based Han Chinese (244...
Suboptimal health status (SHS) is a physical state between and disease, characterized by the perception of complaints, general weakness, chronic fatigue low energy levels. SHS proposed ancient concept traditional Chinese medicine (TCM) from perspective preservative, predictive personalized (precision) medicine. We previously created suboptimal questionnaire 25 (SHSQ-25), novel instrument to measure SHS, validated in various populations. SHSQ-25 thus affords window opportunity for early...
More than half of all known proteins, and almost membrane extra-cellular proteins have oligosaccharide structures or glycans attached to them. Defects in glycosylation pathways are directly involved at least 30 severe human diseases.A multiple center cross-sectional study (China, Croatia, Scotland) was carried out investigate the possible association between hypertension IgG glycosylation. A hydrophilic interaction chromatography fluorescently labeled used analyze N-glycans plasma samples...
Abstract Background Concurrent atherogenic dyslipidemia and elevated inflammation are commonly observed in overt hyperglycemia have long been proposed to contribute diabetogenesis. However, the temporal relationship between them effect of their cumulative co-exposure on future incident type 2 diabetes (T2D) remains unclear. Methods Longitudinal analysis data 52,224 participants from a real-world, prospective cohort study (Kailuan Study) was performed address high-sensitivity C-reactive...
Glycosylation significantly affects protein structure and function thus participates in multiple physiologic pathologic processes. Studies demonstrated that immunoglobulin G (IgG) N-glycosylation associates with the risk factors of ischemic stroke (IS), such as aging, obesity, dyslipidemia, type 2 diabetes, hypertension. The study aimed to investigate association between IgG IS a Chinese population. glycome composition patients (n = 78) cerebral arterial stenosis (CAS) 75) controls 77) were...
Alternative N-glycosylation has significant structural and functional consequences on immunoglobulin G (IgG) can affect immune responses, acting as a switch between pro- anti-inflammatory IgG functionality. Studies have demonstrated that is associated with ageing, body mass index, type 2 diabetes hypertension. Herein, we patterns of glycosylation are blood lipids in cross-sectional study including 598 Han Chinese aged 20–68 years. The glycome composition was analysed by ultra-performance...
Suboptimal health status (SHS) is a physical state between and illness, previous studies suggested that SHS associated with majority components of cardiovascular metrics defined by American Heart Association (AHA). We investigated the association in cross-sectional analysis China suboptimal cohort study (COACS) consisting 4313 participants (60.30% women) aged from 18 to 65 years old. The respective prevalence 7.10%, 9.18%, 10.04% 10.62% first, second, third fourth quartiles ideal (CVH) (P...
Immunoglobulin G (IgG) is the most abundant serum antibody which structural characteristics and effector functions are modulated through attachment of various sugar moieties called glycans. Composition IgG N-glycome changes with age an individual in different diseases. Variability glycosylation within a population well studied known to be affected by both genetic environmental factors. However, global inter-population differences have never been properly addressed. Here we present...
N-glycans play an essential role in biological process and are associated with age, gender, body mass parameters Caucasian populations, whereas no study has been reported Chinese populations. To investigate the correlation between N-glycan structures metabolic syndrome (MetS) components, we conducted a population-based 212 Han individuals. The replication was performed on 520 unrelated individuals from Croatian island Korčula. most prominent observation consistent positive correlations...
ContextThe Chinese government launched a comprehensive healthcare reform to tackle challenges health equities. Medical education will become the key for successful reform.PurposeWe describe current status of medical degree system and its evolution over last 80 years.ContentProgress has been uneven, historically punctuated most dramatically by Cultural Revolution. There is great regional disparity. Doctors with limited tertiary may be licensed practice, whereas graduates advanced doctorates...
Suboptimal health status (SHS) has become a new public challenge in China. This study investigated whether high SHS is associated with psychosocial stress, changes cortisol level and/or glucocorticoid receptor (GR) isoform expression. Three-hundred eighty-six workers employed three companies Beijing were recruited. The score was derived from data collection the questionnaire (SHSQ-25). short standard version of Copenhagen Psychosocial Questionnaire (COPSOQ) used to assess job-related stress....
Objective: To evaluate factors associated with myopic shift among primary school children.Methods: In a one-year prospective school-based study, 5052 children from ten schools were enrolled using multi-stage random cluster approach.The baseline examination included non-cycloplegic auto-refractometry and questionnaire interview.Measurements repeated at the follow-up.Results: Among students investigated, 4292 (85.0%) returned for follow-up examination.The mean refractive error...
Both elevated inflammation and atherogenic dyslipidemia are prominent in young-onset diabetes increasingly identified as biologically intertwined processes that contribute to diabetogenesis. We aimed investigate the age-specific risks of type 2 (T2D) upon concomitant chronic dyslipidemia.Age-stratified Cox regression analysis risk incident co-exposure time-averaged cumulative high-sensitivity C-reactive protein (CumCRP) index plasma (CumAIP) among 42,925 nondiabetic participants from a...
Abstract Ageing is a complex biological process with variations among individuals, leading to the development of ageing clocks estimate age. Glycans, particularly in immunoglobulin G (IgG), have emerged as potential biomarkers ageing, changes glycosylation patterns correlating chronological For precision analysis, three different plasma pools were analysed over 26 days tetraplicates, 312 samples total. In short-term variability two cohorts analysed: AstraZeneca MFO cohort healthy individuals...
Abstract Circular RNAs (circRNAs) play an important role in the progression of osteosarcoma. However, precise function circPVT1 osteosarcoma remains elusive. This study aims to explore molecular mechanism underlying involvement cells. We quantified expression using qRT‐PCR both control and cell lines. To investigate roles circPVT1, miR‐490‐5p HAVCR2 vitro, we separately conducted overexpression inhibition experiments for HOS U2OS Cell migration was assessed through wound healing transwell...
Axial spondyloarthritis (axSpA) is an inflammatory rheumatic disease with challenges in diagnosis and activity assessment. While alterations immunoglobulin G (IgG) N-glycosylation have been observed varied diseases, those axSpA remains unclear. This study aims to explore the role of IgG N-glycan profiles axSpA. A clinical case-control was conducted involving patients (n = 138), systemic lupus erythematosus 102), rheumatoid arthritis 106), osteoarthritis 33), gout 41) healthy controls 117)....
The CCAAT/enhancer‐binding protein beta (CEBPB or C/EBP β ) is a transcription factor that plays critical role in cellular differentiation, metabolism, and immune response. Emerging evidence has highlighted its complex involvement both solid hematological cancers, such as hepatocellular carcinoma (HCC) pancreatic ductal adenocarcinoma (PDAC), where it can act an oncogene tumor suppressor, depending on the context. In this study, we describe design evaluation of conjugate formed by small...
Modifiable risk factors have been linked to 45% of dementia cases. Mobile health (mHealth) interventions targeting lifestyle-related with remote coaching the potential reach underserved high-risk populations globally. To date, little is known about implementation such in China. Fifty semi-structured interviews were conducted 14 participants and 11 coaches involved PRODEMOS trial. This trial investigated whether a coach-supported mHealth application intervention can reduce people aged 55-75...
Suboptimal health status (SHS) has been linked to cardiovascular risk factors, psychosocial stress, and unhealthy lifestyle. These factors also contribute the shortening of telomere length (TL). A case–control study was conducted examine association between subjective measures SHS from behavior perspective objective TL at molecular level. (cases = 294) matched by age, sex, body mass index with ideal (controls using a propensity score matching method. questionnaire-25 (SHSQ-25) used in...
Increased fasting plasma glucose (FPG) is an independent risk factor for type 2 diabetes mellitus (T2DM). The development of systems biology technologies integration multiomics data crucial predicting increased FPG levels. In this case–control study, immunoglobulin (Ig) G glycosylation profiling and genome-wide association analyses were performed on 511 participants, among them 76 had (aged 47.6 ± 6.14 years), 435 decreased or fluctuant 47.9 6.08 years). We identified nine single nucleotide...