A5036232259- Vector-borne infectious diseases
- Protease and Inhibitor Mechanisms
- Viral Infections and Vectors
- Folate and B Vitamins Research
- Pharmacological Effects and Toxicity Studies
- Peptidase Inhibition and Analysis
- Milk Quality and Mastitis in Dairy Cows
- Vitamin D Research Studies
- Metabolism and Genetic Disorders
- Reproductive Physiology in Livestock
- Neonatal Health and Biochemistry
- Parathyroid Disorders and Treatments
- Research on Leishmaniasis Studies
- Bone health and osteoporosis research
- Nutrition and Health in Aging
- Vector-Borne Animal Diseases
- Clinical Laboratory Practices and Quality Control
- Probiotics and Fermented Foods
- Dermatoglyphics and Human Traits
- Paraoxonase enzyme and polymorphisms
- Glycosylation and Glycoproteins Research
- Helminth infection and control
- Mosquito-borne diseases and control
- Esophageal and GI Pathology
- Reliability and Agreement in Measurement
University of Zagreb
2021-2025
Science Research Laboratory
2023-2024
Genos (Croatia)
2023-2024
Univerzitetski Klinički Centar Srbije
2023
Centar za Promociju Nauke
2010-2022
University of Belgrade
2020
ORCID
2007-2014
Abstract Ageing is a complex biological process with variations among individuals, leading to the development of ageing clocks estimate age. Glycans, particularly in immunoglobulin G (IgG), have emerged as potential biomarkers ageing, changes glycosylation patterns correlating chronological For precision analysis, three different plasma pools were analysed over 26 days tetraplicates, 312 samples total. In short-term variability two cohorts analysed: AstraZeneca MFO cohort healthy individuals...
Glucosinolates are chemically stable compounds that exhibit biological activity in the body following hydrolysis catalyzed by enzyme myrosinase. While existing vitro and vivo studies suggest products of glucosinolates predominantly exert beneficial effects both human animal organisms, some have found excessive consumption may lead to toxic anti-nutritional effects. Given primarily ingested diet through dietary supplements commercially available cruciferous vegetables, we investigated...
Sepsis is a systemic inflammatory response triggered by an infectious agent and recognized the World Health Organization as global concern, since it one of major causes severe illness in humans animals. The study changes that can occur saliva serum sepsis contribute to better understanding pathophysiological mechanisms involved process also discover potential biomarkers help its diagnosis monitoring. objective this was characterize salivary proteome pigs with experimentally-induced sepsis....
Changes in the salivary proteome 12 horses with two diseases included equine gastric ulcer syndrome (EGUS), glandular disease (EGGD) (n = 6) and squamous (ESGD) 6), were evaluated using a high-resolution LC-MS/MS analysis of TMT-labelled peptides compared to 10 healthy control horses. Serum was also analysed for comparative purposes. The comparison between EGGD controls showed significant changes proteins, whereas 36 proteins differently abundant ESGD groups. most upregulated case related...
Canine myxomatous mitral valve disease (MMVD) is similar to Barlow’s form of MMVD in humans. These valvulopathies are complex, with varying speeds progression. We hypothesized that the relative abundances serum proteins would help identify consecutive stages and discover new pathways on a systemic level. To distinction-contributing protein panels for onset progression, we compared proteomic profiles from healthy dogs different naturally occurring MMVD. Dogs were divided into experimental...
Abstract Introduction Hemolysis can occur during sample collection, handling and transport. It is more frequent when the non-laboratory staff performs sampling. The aim of this study was to assess nurses' knowledge on causes hemolysis consequential impact laboratory tests results. Additionally, differences in knowledge, related work experience, professional degree previous education about were explored. Materials methods An anonymus survey, containing 11 questions demographics, hemolysis,...
Meningitis due to Streptococcus suis causes high mortality and morbidity on pig farms has increasing zoonotic potential worldwide. Saliva proteome analysis would potentially be useful in elucidating pathophysiological changes mining for new biomarkers diagnose monitor S. infection. The objective of this study was investigate the salivary serum profile piglets with meningitis. LC-MS/MS TMT proteomic approach used analyze saliva samples from 20 male piglets: 10 meningitis healthy. In saliva,...
Retained placenta (RP), a quite common disorder in dairy cows, shows high negative impact on their health status and milk production. To investigate the difference serum proteome between cows with RP physiologic puerperium (PP). Analysis of samples from nine six PP using high-resolution liquid chromatography-tandem mass spectrometry approach. The proteins differing relative abundance groups were classified Protein Through Evolutionary Relationship tool. For pathway enrichment analysis,...
Liver fluke infections are recognised as diseases with worldwide distribution and considerable veterinary public health importance. The giant liver fluke, Fascioloides magna, is an important non-native parasite which has been introduced to Europe, posing a threat the survival of local wildlife populations such red deer (Cervus elaphus). aim study was analyse differences in proteomes between F. magna-infected control groups using label-based high-throughput quantitative proteomics approach....
Bovine mastitis is the most frequent disease on dairy farms, which leads to a decrease in health welfare of animals and great economic losses. This study was aimed at determining quantitative variations milk proteome caused by natural infection Staphylococcus Streptococcus species order gain further understanding any discrepancies pathophysiology host immune responses, independent level. After identification (N = 51) 67) spp., tandem mass tag (TMT)-labeled proteomic liquid...
Summary Determination of 25-hydroxyvitamin D [25(OH)D] represents a unique challenge, considering its lipophilic na - ture. Considering the widespread prevalence vitamin deficiency, which leads to increasing number requests for 25(OH)D determination, immunoassay measurements adjusted automated analyzers are being developed. Because variability among assays, it is often difficult monitor status and supplementation. The aim this study was compare results two immunoassays with high performance...
Introduction: Alpha-1-antitrypsin deficiency (AATD), genetic risk factor for premature chronic obstructive pulmonary disease (COPD), often remains undetected. The aim of our study was to analyse the effectiveness an integrative laboratory algorithm AATD detection in patients diagnosed with COPD by age 45 years, comparison screening approach based on AAT concentration measurement alone.
Incidence of Hyperhomocysteinemia and Mthfr C677T Polymorphism Among Young Patients with Acute Myocardial Infarction is considered an independent risk factor for premature cardiovascular disease. Mutation MTHFR reduces the activity methylenetetra-hydrofolatereductase may cause hyperhomocysteinemia. hyperhomocysteinemia (homocysteine above 12 μmol/L), homocysteine level, distribution genotypes (C/C, C/T T/T) are compared between young patients acute myocardial infarction healthy persons,...
An increased homocysteine (Hcy) concentration may represent a metabolic marker of folate and vitamin B12 deficiency, both significant public health problems. For different reasons, patients with chronic obstructive pulmonary disease (COPD) are prone to these deficiencies. The study evaluates the reliability Hcy in predicting or deficiency patients.A group 50 COPD (28 males/22 females, age (χ̄±SD=49.0±14.5) years was enrolled. A chemiluminescent microparticle immunoassay applied for...
Abstract Valproate is known to disturb the kidney function, and high doses or prolonged intake may cause serum ion imbalance, tubular acidosis, proteinuria, hyperuricosuria, polyuria, polydipsia, dehydration. The aim of this in vivo study was see whether naringin would counter adverse effects high-dose valproate C57Bl/6 mice which extent. As expected, (150 mg/kg bw a day for 10 days) caused hyperkalaemia, more male than female mice. Naringin reversed (25 hyperkalaemia activated antioxidative...