A5021175092- Veterinary Equine Medical Research
- Animal health and immunology
- Osteoarthritis Treatment and Mechanisms
- Reproductive Physiology in Livestock
- Wound Healing and Treatments
- Helminth infection and control
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cancer-related molecular mechanisms research
- Tendon Structure and Treatment
- Extracellular vesicles in disease
- Pancreatitis Pathology and Treatment
- Ruminant Nutrition and Digestive Physiology
- Circular RNAs in diseases
- Sepsis Diagnosis and Treatment
- Galectins and Cancer Biology
- Surgical Sutures and Adhesives
- Diabetic Foot Ulcer Assessment and Management
- Animal Behavior and Welfare Studies
- Rabbits: Nutrition, Reproduction, Health
- Milk Quality and Mastitis in Dairy Cows
- Exercise and Physiological Responses
- Inflammatory mediators and NSAID effects
- Animal Nutrition and Physiology
- Receptor Mechanisms and Signaling
- Acute Kidney Injury Research
University of Copenhagen
2016-2025
University of Liège
2023
Bell Equine Veterinary Clinic
2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Texas A&M University
2022
Linde (United States)
2022
Rigshospitalet
2013-2020
Swedish University of Agricultural Sciences
2014
Steno Diabetes Centers
2008-2013
A high-fat, high-calorie diet is associated with obesity and type 2 diabetes. However, the relative contribution of metabolic defects to development hyperglycaemia diabetes controversial. Accumulation excess fat in muscle adipose tissue insulin resistance may be linked defective mitochondrial oxidative phosphorylation. The aim current study was investigate acute effects short-term overfeeding on glucose metabolism young men. We studied 5 days' high-fat (60% energy) (+50%) versus a control...
In order to investigate the dose dependency and individual variability of lipopolysaccharide (LPS)-induced acute phase protein response in cattle, 8 nonlactating, nonpregnant Danish Holstein cows were challenged 3 times each by intravenous injection increasing doses (10, 100, 1000 ng/kg, consecutively) Escherichia coli LPS with 3-wk intervals. All resulted a rapid increase serum concentrations haptoglobin amyloid A (SAA) decrease albumin all cows. Serum proteins (APP) remained altered for...
Abstract Objective —To determine serum amyloid A (SAA) concentrations in and synovial fluid from healthy horses with joint disease assess the effect of repeated arthrocentesis on SAA fluid. Animals —10 21 various types disease. Procedures —Serum samples were obtained each horse. In 5 10 horses, was 9 times. Concentrations determined via immunoturbidometry. Results less than assay detection limit did not change response to arthrocentesis. Synovial significantly higher suspected bacterial...
Early recognition of excessive inflammation and infectious complications after surgery, leading to early institution therapy, reduces post operative discomfort facilitates recovery. Because serum amyloid A (SAA) is a highly sensitive marker inflammation, measurements SAA other acute phase reactants in the equine surgical patient may be valuable assisting clinical assessment inflammation.To investigate changes inflammatory markers castration correlate levels with severity castration.Leucocyte...
Objective— To evaluate the postoperative inflammatory response of horses to elective surgery varying intensity. Study Design— Prospective longitudinal study. Animals— Horses referred 2 hospitals for either arthroscopic removal a unilateral osteochondritic lesion in tibiotarsal joint (minimal surgical trauma, n=11), correction recurrent laryngeal neuropathy by laryngoplasty and ventriculectomy (intermediate n=10) or an ovarian tumor laparotomy (major n=5). Methods— had thorough clinical...
The objective of the study was to evaluate gene expression inflammatory cytokines (interleukin [IL]-1β, IL-6, IL-8, IL-10, tumor necrosis factor [TNF]-α, IL-1 receptor antagonist [ra] and serum amyloid A (SAA) in endometrial tissue circulating leukocytes response uterine inoculation 105 colony forming units (CFU) Escherichia coli mares. Before inoculation, mares were classified as resistant or susceptible persistent endometritis based on their infusion 109 killed spermatozoa histological...
The concentrations of the two acute phase proteins, serum amyloid A and haptoglobin, in milk were compared 10 cows with clinical mastitis, 11 extramammary inflammatory conditions clinically healthy control cows. both proteins higher mastitis than other groups. Four had above 100 pg/ml, but negligible milk, indicating that a pathogen must be present mammary gland for to accumulate milk. protein increased significantly increasing somatic cell count, suggesting they may indicators severity an infection.
Low birth weight (LBW) is an independent risk factor of insulin resistance and type 2 diabetes. Recent studies suggest that mitochondrial dysfunction impaired expression genes involved in oxidative phosphorylation (OXPHOS) may play a key role the pathogenesis aging The aim this study was to determine whether LBW humans associated with skeletal muscle.Mitochondrial capacity for ATP synthesis assessed by (31)phosphorus magnetic resonance spectroscopy forearm leg muscles 20 young, lean men 26...
Peritoneal fluid (PF) analysis is a valuable diagnostic tool in equine medicine. Markers such as serum amyloid A (SAA) and haptoglobin (Hp) could facilitate the diagnosis of inflammatory abdominal conditions.The objectives were to (1) establish reference intervals (RI) for SAA Hp PF healthy horses, (2) compare concentrations between horses with colic, (3) assess correlation concentrations.Serum determined by automated assays prospectively enrolled colic. RIs calculated, group compared...
Background The acute phase proteins ( APP ) serum amyloid A SAA ), haptoglobin, and fibrinogen are valuable blood biomarkers in equine inflammatory diseases, but knowledge of factors influencing their concentrations peritoneal fluid PF horses with colic is needed. Objectives objective this study was to investigate the influence demographics (age, sex, breed), disease process (simple obstruction, strangulating inflammatory), location, duration, hypovolemia, admission hospital on , lactate...
Postpartum dysgalactia syndrome (PDS) in sows is difficult to diagnose and the pathogenesis obscure. Hormonal changes related disease are often distinguish from those found normal transition period gestation lactation. The study aimed investigate metabolic hormonal PDS with goal of identifying potential biomarkers suffering (PDS+). Selected were examined by comparing 38 PDS+ negative (PDS-) sows. sampled every 24 h 60 ante partum (a.p.) 36 post (p.p.).Compared baseline (60 a.p.), cortisol...
Abstract Background MicroRNAs, a class of small noncoding RNAs, serve as post‐transcriptional regulators gene expression and are present in stable quantifiable form biological fluids. MicroRNAs may influence intra‐articular responses the course disease, but very little is known about their temporal changes osteoarthritis. Objectives To identify miRNAs characterise abundance SF from horses with experimentally induced We hypothesised that miRNA would change during disease progression. Study...