A5012409547- Osteoarthritis Treatment and Mechanisms
- Lower Extremity Biomechanics and Pathologies
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Musculoskeletal pain and rehabilitation
- Rheumatoid Arthritis Research and Therapies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Pain Mechanisms and Treatments
- Pharmacology and Obesity Treatment
- Inflammatory mediators and NSAID effects
- Bone and Joint Diseases
- Musculoskeletal synovial abnormalities and treatments
- Tendon Structure and Treatment
- Musculoskeletal Disorders and Rehabilitation
- Orthopedic Surgery and Rehabilitation
- Meta-analysis and systematic reviews
- Pain Management and Placebo Effect
- Spine and Intervertebral Disc Pathology
- Cerebral Palsy and Movement Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Healthcare and Venom Research
- Health Systems, Economic Evaluations, Quality of Life
- Occupational Health and Performance
Frederiksberg Hospital
2016-2025
Copenhagen University Hospital
2016-2025
University of Copenhagen
2014-2025
Bispebjerg Hospital
2017-2023
Parker Institute for Cancer Immunotherapy
2017-2019
University of Pennsylvania
2017
University of California, San Francisco
2014
University of Southern California
2014
Children's Cancer Center
2014
Baylor College of Medicine
2014
Objective To compare the efficacy of an exercise and education programme with open-label placebo given as intra-articular injections inert saline on pain function in individuals knee osteoarthritis (OA). Methods In this open-label, randomised controlled trial, we recruited adults aged ≥50 years symptomatic radiographically confirmed OA Denmark. Participants were 1:1 to undergo 8-week or four over 8 weeks. Primary outcome was change from baseline week 9 Knee Injury Osteoarthritis Outcome...
Summary The aim of this study was to examine the learning effect during a set isokinetic measurements, evaluate reliability Biodex System 3 PRO dynamometer, and compare Lido Active dynamometers on both extension flexion over elbow knee at 60° s −1 . Thirteen (nine women, four men) healthy participants were measured five times using once dynamometer. intervals between first tests 20 min, 1 week 4 5. Between measurements there min time interval. When comparing (Biodex), no systematic an...
Medial knee osteoarthritis (OA) is characterized by pain and associated with abnormal moments during walking. The relationship between OA gait changes remains to be clarified, a better understanding of this link could advance the treatment prevention disease progression. This study investigated in walking following experimental healthy volunteers, whether these replicated joint observed medial patients.In crossover study, 34 subjects were tested on 3 different days; analyses conducted...
Objective Exercise has beneficial effects on pain in knee osteoarthritis (OA), yet the underlying mechanisms are unclear. The purpose of this study was to investigate exercise pressure–pain sensitivity patients with OA. Methods In a randomized controlled trial, participants were assigned 12 weeks supervised therapy (ET; 36 sessions) or no attention control group (CG). Pressure–pain assessed by cuff pressure algometry calf most symptomatic leg. coprimary outcomes thresholds (PPTs) and...
The aim of the study was to investigate distribution net joint moments in lower extremities during walking on high-heeled shoes compared with barefooted at identical speed. Fourteen female subjects walked 4 km/h across three force platforms while they were filmed by five digital video cameras operating 50 frames/second. Both and (heel height: 9 cm) recorded. Net calculated 3D inverse dynamics. EMG recorded from eight leg muscles. knee extensor moment peak first half stance phase doubled when...
Objective To compare results of obese patients with knee osteoarthritis (OA) who, after an intensive weight loss regimen, received 1 year either dietary support (D), a knee‐exercise program (E), or “no attention” (C; control group). Methods We conducted randomized, 2‐phase, parallel‐group trial. A total 192 participants OA were enrolled; the mean age was 62.5 years and 81% women entry 103.2 kg. In phase 1, all randomly assigned to 3 groups began regimen 400–810 1,250 kcal/day for 16 weeks (2...
Exercise is universally recommended as a primary strategy for the management of knee osteoarthritis (OA) pain. The recommendations are based on results from more than 100 randomized controlled trials (RCTs) that compare exercise to no-attention control groups. However, due inherent difficulties with adequate placebo control, participant blinding and use patient reported outcomes, existing RCT evidence imperfect. To better understand used support causal relationship between OA pain relief, we...
Osteoarthritis (OA) of the knee is most frequent form arthritis and a cause pain disability. Combined nonpharmacologic pharmacologic treatments are recommended as optimal treatment approach, but no evidence supports recommendation.To assess clinical benefits an intra-articular corticosteroid injection given before exercise therapy in patients with OA knee.We performed randomized, blinded, placebo-controlled trial evaluating benefit vs placebo at outpatient clinic from October 1, 2012,...
Background and ObjectivesThere is considerable actual potential waste in research. The aim of this article to describe how using an evidence-based research approach before conducting a study helps ensure that the new truly adds value.Study Design SettingEvidence-based use prior systematic transparent way inform so it answering questions matter valid, efficient, accessible manner. In second series, we apply starting study.ResultsBefore performed, researchers need provide solid justification...
This study assessed the effects of 12-week supervised resistance training combined with home-based physical activity on fitness, cancer-related fatigue, depressive symptoms, health-related quality life (HRQoL), and satisfaction in female breast cancer survivors.A parallel-group, outcome assessor-blinded, randomized controlled trial included 60 survivors who had completed their core treatments within previous 10 years. Through computer-generated simple randomization, participants were...