Klara Brunnhuber

ORCID: 0000-0001-6787-4405
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About
Contact & Profiles
Research Areas
  • Meta-analysis and systematic reviews
  • Health Sciences Research and Education
  • Health Systems, Economic Evaluations, Quality of Life
  • Clinical practice guidelines implementation
  • Ethics in Clinical Research
  • Cardiac, Anesthesia and Surgical Outcomes
  • Blood Pressure and Hypertension Studies
  • Health and Medical Research Impacts
  • Health Policy Implementation Science
  • Artificial Intelligence in Healthcare and Education
  • Clusterin in disease pathology
  • Pain Management and Placebo Effect
  • Chronic Disease Management Strategies
  • Hormonal Regulation and Hypertension
  • Traumatic Brain Injury Research
  • Chronic Kidney Disease and Diabetes
  • Obesity and Health Practices
  • Persona Design and Applications
  • Clinical Reasoning and Diagnostic Skills
  • Academic Writing and Publishing
  • Electronic Health Records Systems
  • Health Promotion and Cardiovascular Prevention
  • Primary Care and Health Outcomes
  • Health and Lifestyle Studies
  • Statistical Methods in Clinical Trials

RELX Group (United Kingdom)
2019-2023

King Saud Medical City
2023

King Saud University
2023

RELX Group (Netherlands)
2021-2022

Bergen Community College
2019

Rode Kruis-Vlaanderen
2019

BMJ Group (United Kingdom)
2006-2015

Health & Medical Publishing Group
2006

To avoid waste of research, no new studies should be done without a systematic review existing evidence, argue Hans Lund and colleagues

10.1136/bmj.i5440 article EN BMJ 2016-10-21

Background and ObjectivesThere is considerable actual potential waste in research. The aim of this article to describe how using an evidence-based research approach before conducting a study helps ensure that the new truly adds value.Study Design SettingEvidence-based use prior systematic transparent way inform so it answering questions matter valid, efficient, accessible manner. In second series, we apply starting study.ResultsBefore performed, researchers need provide solid justification...

10.1016/j.jclinepi.2020.07.019 article EN cc-by Journal of Clinical Epidemiology 2020-09-26

There is considerable actual and potential waste in research. Using evidence-based research (EBR) can ensure the value of a new study. The aim this article, third series, to describe an EBR approach putting results into context.EBR use prior systematic transparent way inform study so that it answering questions matter valid, efficient, accessible manner. In final article we how context existing evidence reach present trustworthy useful conclusion when reporting from clinical study.We method,...

10.1016/j.jclinepi.2020.07.021 article EN cc-by Journal of Clinical Epidemiology 2020-09-23

Abstract Background Results of new studies should be interpreted in the context what is already known to compare results and build state science. This systematic review meta-analysis aimed identify synthesise from meta-research examining if original within health use reviews place their earlier, similar studies. Methods We searched MEDLINE (OVID), EMBASE Cochrane Methodology Register for reporting clinical existing The primary outcome was percentage included using or meta-analyses placing...

10.1186/s13643-022-02062-8 article EN cc-by Systematic Reviews 2022-09-05

Translating narrative clinical guidelines to computable knowledge is a long-standing challenge that has seen diverse range of approaches. The UK National Institute for Health and Care Excellence (NICE) Content Advisory Board (CAB) aims ultimately (1) guide decision support other software developers increase traceability, fidelity consistency in supporting use NICE recommendations, (2) local practice audit intervention reduce unwarranted variation, (3) provide feedback on how future...

10.1002/lrh2.10394 article EN cc-by-nc-nd Learning Health Systems 2023-09-28

Saudi Arabia's ambitious Vision 2030 project was launched in 2016 as a strategy for economic development and national growth, with 11 Realization Programs put charge of its implementation. The backbone Transformation Program the Health Sector has been definition new Model Care aiming to deliver 42 coordinated interventions across 6 Systems Care, clinical guidelines identified key cross-cutting intervention foster use national, evidence-based practices KSA, reduce care variation, promote...

10.1007/s44197-022-00076-y article EN cc-by Journal of Epidemiology and Global Health 2022-11-28

Meta-research has highlighted that up to half of all clinical studies may be redundant and do not add any value. We suggest such unnecessary will continue prepared published unless researchers systematically transparently identify consider the existing evidence. This approach identifying utilizing knowledge base before after conducting a new trial is called Evidence-Based Research (EBR), defined as use prior research in systematic transparent way inform study so it answering questions matter...

10.20452/pamw.16076 article EN Polskie Archiwum Medycyny Wewnętrznej 2021-09-30

Oversatt til spansk av Maria Elena Marquesa, Aitor Herreroa, Eduard Baladiaa, Rodrigo Martinez-Rodrigueza, Andrea Cerverac, Kristian Buhringa, Eliud Aguilar-Barreraa, Samuel Duran-Agueroa, Grupo de trabajo la Red Nutricion Basada en Evidencia (RED-NuBE). Opprinnelig utgave: Lund, H., Brunnhuber, K., Juhl, C., Robinson, Leenaars, M., Dorch, B. F., . Chalmers, I. (2016). Towards evidence based research. Bmj. doi:10.1136/bmj.i5440

10.14306/renhyd.22.1.572 article ES Revista Española de Nutrición Humana y Dietética 2018-01-01

Background Use of earlier research is needed to provide the rationale for starting a study and context in which set results. Explicit use research, through conduct systematic review, also necessary design an efficient informative study. Decisions about informed by review include selection meaningful outcomes assessed way that enables synthesis across studies; this especially areas where core outcome sets do not yet exist. Yet shows there inadequate biased consideration research.

10.1186/1745-6215-16-s3-p10 article EN cc-by Trials 2015-11-24

This practice guideline was developed by the chronic kidney disease (CKD) Task Force, which composed of clinical and methodological experts. The Saudi Arabian Ministry Health its health holding company commissioned this project to support realization Vision 2030's health-care transformation pillar. synthesis these guidelines guided Grading Recommendations Assessment, Development, Evaluation (GRADE)- ADOLOPMENT methodology. final addressed 12 questions on management blood pressure in patients...

10.4103/sjkdt.sjkdt_68_24 article EN cc-by-nc-sa Saudi Journal of Kidney Diseases and Transplantation 2023-12-01

Background: This practice guideline was developed by the Chronic Kidney Disease (CKD) Task Force, which composed of clinical and methodological experts. The Saudi Arabian Ministry Health its Holding Company commissioned this project to support realization Vision 2030's healthcare transformation pillar. Methods: synthesis guided GRADE-ADOLOPMENT methodology. Results: final adoloped addressed 12 questions on blood pressure management in patients with CKD through a set recommendations...

10.20944/preprints202304.0080.v1 preprint EN 2023-04-06

<h3>Objectives</h3> Research on research has shown that many redundant studies would have been avoided if a systematic review conducted prior to starting the new study. These apparently wasteful limit funding available for truly important and relevant research, diminish public's trust in are unethical. Researchers planning study should therefore systematically existing evidence order effectively justify need also interpret results evaluate what adds by systemically analysing (i.e. putting...

10.1136/bmjebm-2019-ebmlive.16 article EN Oral Presentations 2019-07-01

Ob sich heutige medizinische Wissenschaftler, wie ehemals Isaac Newton, als "auf den Schultern von Riesen stehend" sehen oder nicht, die Erwartung sollte sein, dass sie bei der Planung neuer Studien systematisch Gebrauch vorhandener Forschung machen. Obwohl diese Thematik bereits 2005 intensiv diskutiert wurde [1Young C. Horton R. Putting clinical trials into context.Lancet. 2005; 366: 107-108https://doi.org/10.1016/S0140-6736(05)66846-8 pmid:16005318Abstract Full Text PDF PubMed Scopus...

10.1016/j.zefq.2021.12.010 article DE cc-by Zeitschrift für Evidenz Fortbildung und Qualität im Gesundheitswesen 2022-02-01
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