Obesity, a major health problem worldwide, is associated with increased cardiovascular risk factors, such as dyslipidemia, glucose intolerance, and hypertension. We investigated the antioxidative capacity of ethanol extract propolis (EEP) its effect on lipid profile, hepatorenal function, atherogenic indices in mice fed high-fat diet (HFD). EEP (50 mg/kg) was given orally to for 30 days. After treatments, levels serum total triglyceride cholesterol, high density lipoprotein (HDL-c) low...

Diabetic dyslipidemia and hyperglycemia contribute to excessive reactive oxygen species (ROS) production, leading deleterious complications, such as nephropathy, atherosclerosis cardiac dysfunction, target major organs in the body. The aim of this study was investigate effect caffeic acid (CA) on mouse weight survival, serum level fasting blood glucose (FBG), lipid parameters atherogenic indices, oxidative damage blood, liver kidney tissue, pathophysiological changes their function markers...

Oxidative stress (OS) mediators, together with the inflammatory processes, are considered as threatening factors for bone health. The aim of this study was to investigate effects flavonoids naringenin and chrysin on OS, inflammation, degradation in retinoic acid (13cRA)-induced secondary osteoporosis (OP) rats. We analysed changes body uterine weight, biochemical parameters (bone mineral density (BMD), content (BMC), markers turnover), geometry parameters, histology, OS haematological levels...

Glucosinolates are chemically stable compounds that exhibit biological activity in the body following hydrolysis catalyzed by enzyme myrosinase. While existing vitro and vivo studies suggest products of glucosinolates predominantly exert beneficial effects both human animal organisms, some have found excessive consumption may lead to toxic anti-nutritional effects. Given primarily ingested diet through dietary supplements commercially available cruciferous vegetables, we investigated...

Polyphenols of Laurel and Myrtle exhibit structural diversity, which affects bioavailability, metabolism, bioactivity. The gut microbiota plays a key role in modulating the production, bioavailability and, thus biological activities phenolic metabolites, particularly after intake food containing high-molecular-weight polyphenols. aim this study was to investigate whether polyphenolic components aqueous extract have beneficial effects on rat health. growth lactic acid bacteria (LAB),...

In our study, we assessed whether the addition of basil, fennel, oregano, rosemary, and chili can improve oxidative stability sensory properties flaxseed oil (FO) during 180 days storage or induce contamination by microorganisms. Results showed that spices herbs in FO affected hydrolytic changes, but far less than 2% free fatty acids after storage, which was line with regulations. Further, decreased peroxide value (even up to 68.7% oregano) vs. whose increased indicating prolongation shelf...

Essential oils (EOs) from aromatic and medicinal plants, such as myrtle (Myrtus communis L.) Laurel (Laurus nobilis L.), are gaining popularity a potential ingredient in functional foods nutraceuticals. This study aims to investigate whether the essential could be effective weight control, antioxidative antilipidemic status of rats by affecting microbiota its enzymes activity changes intestinal enzyme affect health rats. The intragastric application laurel EOs for two weeks affects loss,...

Lactiplantibacillus plantarum D13 shows antistaphylococcal and antilisterial activity, probably due to the synthesis of a presumptive bacteriocin with antibiofilm capacity released in cell-free supernatant (CFS), whose inhibitory effect is enhanced by cocultivation susceptible strains. An silico analysis genome strain confirmed pln gene cluster. Genes associated plantaricin biosynthesis, structure, transport, antimicrobial immunity were identified. Furthermore, predicted homology-based 3D...

Disruption of any stage iron homeostasis, including uptake, utilization, efflux, and storage, can cause progressive damage to peripheral organs. The health hazards associated with occupational exposure inhalation anesthetics (IA) in combination chronic overload are not well documented. This study aimed investigate changes the concentration essential metals organs rats after IA. aim was also determine how IA affects tissue metal hepcidin-ferritin levels, MMP levels according physiological,...

Nutrition is an important factor that influences bone metabolism, the endocrine and/or paracrine system, and bone-active mineral elements homeostasis. We studied antiosteoporotic effects of grape seed proanthocyanidins extract, icariin or alendronate (ALN) in retinoic acid-induced (13cRA) loss rats. Proanthocyanidins have beneficial on health; they improved weight reduction, length diameter bone, calcium, phosphorus content ash, density (BMD), biochemical markers turnover uterus atrophy...

Quercetin (QU), a hyperthermic sensitizer, when combined with cisplatin (CP) affects tumor growth. To determine the effects of QU and CP their interactions, multimodal treatment in vitro vivo models under physiological conditions was performed. In vitro, different sensitivity T24 UMUC human bladder cancer cells observed after short-term exposure to (2 h) (1 h). Effects both compounds were investigated at low high micromolar concentrations 50 µM, respectively) thermal conditions. acted...

Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer, interplay TAM tumor cells represents a promising target future therapeutic approaches. We investigated effect gallic acid (GA) caffeic (CA) as strong antioxidant anti-inflammatory agents on growth, angiogenesis, macrophage polarization, oxidative stress angiogenic model caused by intraperitoneal (ip) inoculation Ehrlich ascites (EAT) (2.5 × 106) in Swiss albino mouse. Treatment with GA or CA at...

The aim of this study was to investigate the therapeutic potential resveratrol in combination with cisplatin on inhibition tumour angiogenesis, growth, and macrophage polarization mice bearing solid form an Ehrlich ascites (EAT) that were exposed whole-body hyperthermia treatment. In addition, we investigated whether a multimodal approach could abolish resistance cells through modulation histone deacetylase (HDAC) activity levels heat shock proteins (HSP70/HSP90) contribute direct toxicity...

Vitamin A and its metabolites are key regulators of the development adipose tissue associated metabolic complications. The aim this study was to determine effect high fat diet 13-cis retinoic acid (13 cRA) application on parameters, adipogenic inflammatory indicators in female Lewis rats. Female rats strain were fed standard laboratory (STD) (HFD, 45% saturated fatty acids) during 30 days. groups divided into additional 3 (6 each): two experimental that received 13 cRA orally a daily basis...

COPD is progressive lung disease with known higher cardiovascular (CV) risk, mainly attributed to smoking of cigarettes as the main etiological factor disease. The aim this study was compare CV risk in patients control groups smokers and non-COPD investigate relation function variables, severity, Systemic Coronary Risk Estimation (SCORE) calculation, arterial stiffness (AS) values, biological systemic inflammatory markers.A total 208 subjects were included study: 61 diagnosed COPD, 83...

The aim of this study was to evaluate how nettle (Urtica dioica L.) water extract consumption would interact with regulators peroxysomal lipid oxidation, histone deacetylase, and markers oxidative stress in the liver blood levels male female C57Bl6 mice. Metabolically unchallenged (healthy) mice (n = 5 per sex) were treated a dose 40 mg total polyphenols kg body weight. applied daily along normal diet for 15 days. serum triglycerides, cholesterol, HDL, LDL, PPAR-α, PPAR-γ, PGC-1-α, ACOX1,...

Iron, as an essential microelement, is involved in cell proliferation, metabolism, and differentiation. It also modulates the fate function of macrophages hematopoiesis macrophage-mediated inflammatory responses. On other hand, anesthetics can affect process by modulating response to stress or functions immune cells. The aim this paper understand how excessive iron intake alters physiological, functional characteristics peripheral tissues whether different alter metabolism regarding...

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Abstract Valproate is known to disturb the kidney function, and high doses or prolonged intake may cause serum ion imbalance, tubular acidosis, proteinuria, hyperuricosuria, polyuria, polydipsia, dehydration. The aim of this in vivo study was see whether naringin would counter adverse effects high-dose valproate C57Bl/6 mice which extent. As expected, (150 mg/kg bw a day for 10 days) caused hyperkalaemia, more male than female mice. Naringin reversed (25 hyperkalaemia activated antioxidative...

<p>Reactive oxygen species (ROS) play a role in numbered of degenerative conditions including psoriasis. Psoriasis is chronic inflammatory disease who’s the etiopathogenesis not yet completely understood, and therefore there no standardized therapeutical approach. Flavonoids, recognized as potent antioxidants, are multifunctional molecules that can act anti-inflammatory antiproliferative agents through modulation multiple signaling pathways. The present study was designed to...

The health benefits of polyphenols are based on their bioavailability, which is why a significant portion research focuses factors that affect bioavailability. Previous studies suggest the intake along with macronutrients in food represents one key influencing bioavailability and, consequently, biological activity organism. Since human diet mainly consumed together macronutrients, this study investigated vivo absorption, metabolism, and distribution polyphenolic compounds from water extract...