A5103210029- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Bioinformatics and Genomic Networks
- Circular RNAs in diseases
- Retinoids in leukemia and cellular processes
- Curcumin's Biomedical Applications
- Traditional Chinese Medicine Analysis
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Flavonoids in Medical Research
- Traditional Chinese Medicine Studies
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Berberine and alkaloids research
- Pharmacological Effects of Natural Compounds
- Phytochemistry and biological activity of medicinal plants
- interferon and immune responses
- Immune cells in cancer
- Quinazolinone synthesis and applications
- RNA Interference and Gene Delivery
- Ginseng Biological Effects and Applications
Shanghai University of Traditional Chinese Medicine
2016-2025
Tongji University
2024
First Affiliated Hospital of Zhengzhou University
2022
Shanghai University
2009-2020
State Administration of Traditional Chinese Medicine of the People's Republic of China
2018
Tianjin University of Traditional Chinese Medicine
2013
Metastasis is a major cause of death in patients with breast cancer. In the process cancer development, epithelial-mesenchymal transition (EMT) crucial to promoting invasion and migration tumor cells. previous study, role resveratrol metastasis was investigated MDA-MB-231 (MDA231) human cells xenograft-bearing mouse model. Additionally, related mechanism explored. present vitro Transwell assays showed that can inhibit transforming growth factor (TGF)-β1-induced MDA231 concentration-dependent...
Cancer cells with stem cell-like properties contribute to the development of resistance chemotherapy and eventually tumor relapses. The current study investigated potential curcumin reduce breast cancer cell (BCSC) population for sensitizing mitomycin C (MMC) both in vitro vivo. Curcumin improved sensitivity paclitaxel, cisplatin, doxorubicin lines MCF-7 MDA-MB-231, as shown by more than 2-fold decrease half-maximal inhibitory concentration these chemotherapeutic agents. In addition,...
Curcumin, a natural compound derived from the turmeric rhizome Curcuma longa Linn, has anticancer and chemoresistance reduction biological activities. We evaluated efficacy of curcumin in sensitizing chemotherapy drugs through regulation Bcl-2-mediated apoptosis breast cancer stem-like cells (BCSCs). Cell survival was measured using MTT assay. Apoptosis-related proteins were observed western blot analysis. Apoptosis detected with flow cytometric analysis by Hoechst 33258 staining. The...
Triple-negative breast cancer (TNBC) is a refractory type of that does not yet have clinically effective drugs. The aim this study to investigate the synergistic effects and mechanisms resveratrol combined with cisplatin on human MDA-MB-231 (MDA231) cell viability, migration, invasion in vivo vitro. In vitro, MTS assays showed inhibits viability as concentration-dependent manner, produced (CI < 1). Transwell assay treatment TGF-β1-induced migration invasion. Immunofluorescence confirmed...
Background/Aim: The synergistic combinations of natural products have long been the basis Traditional Chinese herbal Medicine formulas. In this study, we investigated effects a combination berberine and evodiamine against human breast cancer MCF-7 cells in vitro vivo, explored its mechanism. Materials Methods: Cell survival was measured using MTT assay. Apoptosis-related proteins were observed western blot analysis. Apoptosis detected with flow cytometric analysis by Hoechst 33258 staining....
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) has a high mortality rate and often occurs in sepsis. Yantiao Formula (YTF) is used effectively clinic but its mechanism the treatment of ALI induced by sepsis remains unelucidated. This study aims to explore potential molecular mechanisms YTF sepsis- ALI. Using ACQUITY UPLC I-Class, chemical components contained were characterized. The network pharmacology approach was predict targets for treating induce Single-cell RNA...
Vascular endothelial growth factor (VEGF) plays a major role in angiogenesis by stimulating cells. Increase cyclic AMP (cAMP) level inhibits VEGF-induced cell proliferation and migration. Cyclic nucleotide phosphodiesterases (PDEs), which specifically hydrolyse nucleotides, are critical the regulation of this signal transduction. We have previously reported that PDE2 PDE4 up-regulations human umbilical vein cells (HUVECs) implicated inhibition activities prevents development vitro increasing...
// Hui Zhang 1 , Xiu-Li Yan 2 Xin-Xin Guo Miao-Juan Shi Yi-Yu Lu Qian-Mei Zhou Qi-Long Chen Yi-Yang Hu 3 Lie-Ming Xu Shuang Huang 1, 4 and Shi-Bing Su Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Medicine, Pudong, 201203, China Yueyang Hospital Integrated Western Hongkou, 200437, Shuguang Hospital, Department Anatomy Cell Biology, Florida College Gainesville, FL, USA Correspondence to: Su, email: shibingsu07@163.com Keywords: MiR-27a; predictor;...
In traditional Chinese medicine (TCM) clinical practice, TCM syndromes help to understand human homeostasis and guide individualized treatment. However, the syndrome changes with disease progression, of which scientific basis mechanism remain unclear.To demonstrate underlying dynamic in syndrome, we applied a network biomarker (DNB) algorithm obtain DNBs based on transcriptomic data patients chronic hepatitis B typical syndromes, including healthy controls liver-gallbladder dampness-heat...
Fuzheng-Huayu (FZHY) formula has been found to have a satisfactory effect on hepatitis B-caused cirrhosis (HBC) treatment. However, the efficacy evaluation of FZHY is often challenging. In this study, randomized, double-blind and placebo-controlled trial was used evaluate therapeutic in HBC trial, 35 medical indexes were detected, 14 had statistically-significant difference before compared after trial. Importantly, Child-Pugh score also demonstrated having efficacy. Furthermore, microRNA...
Abstract Hepatitis B is one of most etiologies Liver cirrhosis in China, and clinically lacks the effective strategy for caused (HBC) therapy. As a complementary alternative medicine, Chinese Traditional Medicine (TCM) has special therapeutic effects HBC. Here, we focus on evolution process HBC TCM syndromes, which was from Excessive (Liver-Gallbladder Dampness-Heat Syndrome, LGDHS) to Deficient (Liver-Kidney Deficiency LKYDS) via Excessive-Deficient syndrome (Liver-Depression...
Background. Formononetin, an active ingredient isolated from the traditional Chinese medicinal herb Astragalus membranaceus , has anticancer and chemoresistance-reducing biological activities. We evaluated efficacy of formononetin in improving tumoricidal effect everolimus by suppressing mTOR pathway breast cancer cells. Methods. Cell survival was assessed using MTT assay. Apoptosis detected flow cytometry. Proteins related to were real-time PCR Western blot analysis . Results. The results...
Abstract Hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths in Asia and Africa. Developing effective non-invasive biomarkers HCC for individual patients remains an urgent task early diagnosis convenient monitoring. Analyzing the transcriptomic profiles peripheral blood mononuclear cells from both healthy donors with chronic HBV infection different states (i.e. carrier, hepatitis B, cirrhosis, HCC), we identified set 19 candidate genes...
Background Shenqi Fuzheng injection (SQFZ) combined with chemotherapy can sensitize tumour cells. However, the mechanisms underlying SQFZ’s effects remain unknown. In human breast cancer cell lines and M2 macrophages, we showed that SQFZ was a significantly potent agent of sensitization. Methods The line, MDA-MB-231/DDP, acute leukaemia mononuclear THP-1, were used. MDA-MB-231/DDP xenografts established to monitor growth. Resistance-associated proteins examined by western blotting. Levels...
Traditional Chinese medicine (TCM) treatment is regarded as a safe and effective method for chronic hepatitis B (CHB), which requires traditional diagnosis to distinguish the TCM syndrome. In this study, we study differences similarities among excessive, excessive-deficient, deficient syndromes, by an integrative comparative analysis of weighted miRNA expression or miRNA-target network in CHB patients. We first calculated differential expressed miRNAs based on random module t -test...
Cardiomyocytes apoptosis can lead to heart failure. Conventional and alternative drugs, such as Chinese herbal remedies, have been developed target cardiomyoblast cells apoptosis. In this study, we investigated the effects of ginsenoside Rb1 (Rb1), an active compound, which is isolated from Notoginseng Ginseng on isoproterenol-(ISO-) induced in rat cardiomyocytes its mechanism vivo vitro. reduced ISO-induced H9c2 cells. The effect was significantly suppressed by H89 (inhibitor for PKA), but...
Traditional Chinese medicine (TCM) treatment is regarded as a safe and effective method for many diseases. In this study, the characteristics among excessive, excessive-deficient, deficient syndromes of Hepatocellular carcinoma (HCC) were studied using miRNA array data. We first calculated differentially expressed miRNAs based on random module t -test classified three TCM HCC SVM method. Then, weighted miRNA-target networks constructed different predicted targets. Subsequently, prioritized...