A5100397114- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Advanced Chemical Physics Studies
- Metal complexes synthesis and properties
- Microfluidic and Capillary Electrophoresis Applications
- Crystal structures of chemical compounds
- Ion-surface interactions and analysis
- Chemical Thermodynamics and Molecular Structure
- Spectroscopy and Laser Applications
- Adsorption, diffusion, and thermodynamic properties of materials
- Asymmetric Synthesis and Catalysis
- Ionic liquids properties and applications
- Atmospheric Ozone and Climate
- Advanced Proteomics Techniques and Applications
- Chromatography in Natural Products
- Spectroscopy Techniques in Biomedical and Chemical Research
- Metal-Organic Frameworks: Synthesis and Applications
- Dye analysis and toxicity
- Magnetism in coordination complexes
- Zeolite Catalysis and Synthesis
- Oil and Gas Production Techniques
- Analytical chemistry methods development
- Chemical Synthesis and Characterization
- Crystallography and molecular interactions
- Advanced Chemical Sensor Technologies
China University of Petroleum, Beijing
2019-2025
Sichuan University of Science and Engineering
2023
Xiamen University
2015-2022
Xinjiang University
2015-2022
Guangzhou University of Chinese Medicine
2019-2020
Fuzhou University
2020
Qufu Normal University
2013-2020
Ningbo Center for Disease Control and Prevention
2015-2016
Changchun Institute of Optics, Fine Mechanics and Physics
2013
Chinese Academy of Sciences
2013
An interaction-induced dipole surface (IDS) and a potential energy (PES) of collisionally interacting molecular hydrogen pairs H(2)-H(2) was recently obtained using quantum chemical methods (Li, X.; et al. Computational Methods in Science Engineering, ICCMSE. AIP Conf. Proc. 2009, ; see also Li, Int. J. Spectrosc. 2010, ID 371201). The data account for substantial rotovibrational excitations the H(2) molecules, as encountered at temperatures thousands kelvin (e.g., atmospheres "cool" stars)....
Abstract Simultaneously acquiring chemical and topographical information within a single cell at nanoscale resolutions is vital to cellular biology, yet it remains great challenge due limited lateral detection sensitivities. Herein, the development of near‐field desorption mass spectrometry for correlated imaging reported, thereby bridging gap between laser‐based (MS) methods multimodal single‐cell imaging. Using this integrated platform, an resolution 250 nm 3D topographically reconstructed...
Mass spectrometry imaging (MSI) has become a powerful tool in diverse fields, such as chemistry, physics, materials, and life science. Although research is getting more prevalent, it limited by high-resolution (HR) instrumental development. Recently, unceasing efforts have been made toward taking spatial resolution from the microscale to nanoscale, especially for near-field based techniques. These emerging unique features behind mass (HR-MSI) provide new possibilities various aspects of...
Abstract The visualization of temporal and spatial changes in the intracellular environment has great significance for chemistry bioscience research. Mass spectrometry imaging (MSI) plays an important role because its unique advantages, such as being label‐free high throughput, yet it is a challenge laser‐based techniques due to limited lateral resolution. Here, we develop simple, reliable, economic nanoscale MSI approach by introducing desorption laser with micro‐lensed fiber. Using this...
An asymmetric cyclization reaction of azadienes and azlactones was investigated by employing a Cinchona squaramide catalyst, which could afford series benzofuran-fused six-membered heterocycles containing α,α-disubstituted amino acid unit in highly diastereoselective (>20:1 dr) enantioselective (up to 99% ee) manner with good excellent yields 92%). A plausible pathway proposed explain the process.
Exploring the three-dimensional (3D) drug distribution within a single cell at nanoscale resolution with mass spectrometry imaging (MSI) techniques is crucial in cellular biology, yet it remains great challenge due to limited lateral resolution, detection sensitivities, and reconstruction problems. Herein, microlensed fiber laser desorption post-ionization time-of-flight spectrometer (MLF-LDPI-TOFMS) was developed for 3D of two anticancer drugs cells 500 × nm3 voxel resolution. Nanoscale...
Abstract The fragmentation of proton‐bound clusters [B 1 —H—B 2 ] + amine bases B and were studied at collision energies 10–50 eV in the quadrupole cell a hybrid tandem mass spectrometer. relative abundances fragment ions H correlated with proton affinities amines. 21 amines are reported based on expanded affinity scale Meot‐Ner Sieck [ J. Am. Chem. Soc. 113, 4448 (1991)]. It is found that mixed α‐amino acids can be used to establish simple amino such as glycine, alanine, valine, leucine...
It is well-known that single H3N-HCl and H2O-HCl acid-base pairs do not react to form the ion pairs, H4N(+)Cl(-) H3O(+)Cl(-), in isolation. On basis of ab initio method, we propose a physical method external electric field (Eext) drive proton transfer from acid (HCl) base (NH3/H2O). Our results show when Eext along proton-transfer direction achieves or exceeds critical (Ec), occurs, such as, Ec values for are 54 × 10(-4) 210 au, respectively. And degree can be controlled by modulating...
The present work provides a simple and efficient access to chiral pyrano[2,3-<italic>c</italic>]pyrrole<italic>via</italic>an asymmetric [4 + 2] cyclization reaction catalyzed by cinchona-squaramide catalyst.
The detection sensitivity increased as the sizes of [Cu<sub>2</sub>I<sub>2</sub>(MA)<sub>2</sub>] decreased and selectivity improved by introducing amino-rich ligands.
A highly enantioselective 1,4-addition reaction of azadiene with 3-homoacyl coumarin has been accomplished by low amounts bifunctional cinchona alkaloid catalysis under mild conditions. Varieties benzofuran skeletons were obtained in moderate to high yields (up 99%) excellent enantioselectivities 99% ee) and complete diastereoselectivity.
A novel triethylenetetramine-functionalized magnetic graphene oxide composite was prepared and used as a solid-phase extraction adsorbent for the fast detection of ten trace-level phenolic environmental estrogens in water. The synthesized material carefully characterized by scanning electron microscopy, transmission vibrating sample magnetometry, X-ray photoelectron spectroscopy to confirm structure components. adsorption desorption conditions toward were optimized detailed obtain best...
Deficiency of cyclin-dependent kinase 5 (Cdk5) has been linked to the death postmitotic cortical neurons during brain development. We now report that, in mouse neurons, Cdk5 is capable phosphorylating transcription factor FOXO1 at Ser249 vitro and vivo . Cellular stresses resulting from extracellular stimulation by H 2 O or β-amyloid promote hyperactivation Cdk5, nuclear export inhibition its downstream transcriptional activity. In contrast, a loss leads translocation into nucleus: shift due...
We calculate the collision-induced, roto-translational, polarized, and depolarized Raman spectra of pairs H2 molecules. The Schrödinger equation H2–H2 scattering in presence a weak radiation field is integrated close-coupled scheme. This permits accounting for anisotropy intermolecular potential energy surface thereby it includes mixing polarizability components. static invariants, trace anisotropy, two interacting molecules were obtained elsewhere [Li et al., J. Chem. Phys. 126, 214302...
Abstract Quantum chemical methods are used to obtain the interaction-induced dipole surfaces (IDS) of complexes two interacting (i.e. colliding) molecules, for example H2–H2, H2–He, etc., collisional complexes, along with their potential energy (PES). Eight H2 bond distances, from 0.942 2.801 bohr, chosen each molecule account rotovibrational excitations. Rotovibrational matrix elements these ID and PE computed as necessary study supermolecular ('collision-induced') absorption spectra dense...
For atoms or molecules of D∞h higher symmetry, this work gives equations for the long-range, collision-induced changes in first (Δβ) and second (Δγ) hyperpolarizabilities, complete to order R−7 intermolecular separation R Δβ, R−6 Δγ. The results include nonlinear dipole-induced-dipole (DID) interactions, multipole induction, induction due nonuniformity local fields, back dispersion. pairs containing H He, we have used ab initio values static (hyper)polarizabilities obtain numerical terms Δβ...