A5063906059- Plant Molecular Biology Research
- Plant nutrient uptake and metabolism
- Nanoplatforms for cancer theranostics
- Plant Micronutrient Interactions and Effects
- Photosynthetic Processes and Mechanisms
- Plant Stress Responses and Tolerance
- Nanoparticle-Based Drug Delivery
- Plant Reproductive Biology
- Trace Elements in Health
- Graphene and Nanomaterials Applications
- Legume Nitrogen Fixing Symbiosis
- Photodynamic Therapy Research Studies
- RNA Interference and Gene Delivery
- Plant Gene Expression Analysis
- Plant-Microbe Interactions and Immunity
- Heavy Metal Exposure and Toxicity
- Extracellular vesicles in disease
- Mitochondrial Function and Pathology
- Metalloenzymes and iron-sulfur proteins
- Plant responses to water stress
- Inflammasome and immune disorders
- Carbon and Quantum Dots Applications
- Plant biochemistry and biosynthesis
- Chromosomal and Genetic Variations
- Animal Nutrition and Physiology
Zhejiang University
2013-2025
Soochow University
2019-2025
Qingdao Municipal Center for Disease Control and Prevention
2025
State Key Laboratory of Plant Physiology and Biochemistry
2010-2024
Southwest University
2021-2024
Southeast University
2024
University of Electronic Science and Technology of China
2019-2021
Jilin Medical University
2018
Life University
2013
Hangzhou Normal University
2008
Soil contamination with arsenic (As) can cause phytotoxicity and elevated As accumulation in rice grain. Here, we used a forward genetics approach to investigate the mechanism of arsenate (As(V)) tolerance rice. A mutant hypersensitive As(V), but not As(III), was isolated. Genomic resequencing complementation tests were identify causal gene. The function gene, its expression pattern subcellular localization characterized. OsHAC4 is gene for As(V)-hypersensitive phenotype. encodes...
Immune checkpoint blockade (ICB) therapy shows excellent efficacy against malignancies; however, insufficient tumor immunogenicity and the immunosuppressive microenvironment (TME) are considered as two major stumbling blocks to a broad ICB response. Here, combinational therapeutic strategy is reported, wherein TME-reactive oxygen species/pH dual-responsive signal transducers activators of transcription 3 inhibitor nanoprodrugs MPNPs combined with oncolytic herpes simplex virus 1 virotherapy...
Abstract Cancer immunotherapy is restricted to immune resistance caused by immunosuppressive tumor microenvironment. Pyroptosis involved in antitumor as a new schedule prospective reverse immunosuppression. Herein, acidic microenvironment (TME)‐evoked MRC nanoparticles (MRC NPs) co‐delivering agonist RGX‐104 and photosensitizer chlorine e6 (Ce6) are reported for pyroptosis‐mediated immunotherapy. remodels TME transcriptional activation of ApoE regress myeloid‐derived suppressor cells'...
ABSTRACT The active vitamin D‐degrading enzyme (CYP24A1) is commonly overexpressed in various types of cancer, which associated with poor prognosis cancer patients. Recent studies highlight the antagonism CYP24A1 toward anticancer role D. However, impact on tumorigenesis and its underlying mechanisms largely remains unexplored. This study also found that high mRNA expressions were ovarian lung adenocarcinoma (LUAD) Moreover, we demonstrated overexpression accelerated proliferation,...
Phosphate (Pi) uptake in plants depends on plasma membrane (PM)-localized phosphate transporters (PTs). OsCK2 phosphorylates PTs and inhibits their trafficking from the endoplasmic reticulum (ER) to PM rice (Oryza sativa), but how are dephosphorylated is unknown. We demonstrate that protein phosphatase type 2C (PP2C) OsPP95 interacts with OsPT2 OsPT8 dephosphorylates at Ser-517. Rice overexpressing reduced phosphorylation promoted ER PM, resulting Pi accumulation. Under Pi-sufficient...
Abstract Pyroptosis is demonstrated to trigger antitumor immunity and represents a promising new strategy potentiate cancer immunotherapy. The number of potent pyroptosis inducers, however, limited without tumor‐targeting capability, which inevitably causes damage in normal tissues. Herein, small molecular prodrug paclitaxel‐oxaliplatin rationally synthesized, can be covalently self‐assembled with diselenide‐containing cross‐linking (Dse11), producing diselenide nanoprodrug (DSe@POC) induce...
Ideal root system architecture (RSA) is important for efficient nutrient uptake and high yield in crops. We cloned characterized a key RSA regulatory gene, GRAVITROPISM LOSS 1 (OsGLS1), rice (Oryza sativa L.). The gls1 mutant displays an increased growth angle, longer primary roots, more adventitious roots greater efficiency grain paddy fields. OsGLS1 strongly expressed the tips of seedlings leaves at flowering stage. encodes RING finger E3 ubiquitin ligase mainly localizing basal plasma...
The objective of this study was to investigate the effects low inclusion levels organic trace minerals (iron, copper, manganese, and zinc) on performance, eggshell quality, serum hormone levels, enzyme activities laying hens during late period. A total 405 healthy (HY-Line White, 50-week-old) were randomly divided into 3 treatments, with 9 replications per treatment 15 birds replication. dietary treatments included a basal diet supplemented inorganic at commercial (CON), 1/3 (ITM),...
Low soil phosphorus (P) availability is a major limitation for crop production. The molecular mechanisms underlying plant responses and adaptation to phosphate (Pi) deficiency are unclear. OsbHLH6 (hereafter bHLH6), an uncharacterized rice (Oryza sativa) Pi starvation response gene encoding basic helix-loop-helix protein, was identified by yeast two-hybrid screening using the repressor OsSPX4 SPX4) as bait. bHLH6 expressed in shoots roots, its expression significantly induced deficiency....
Nanomedicine enabled cancer combination immunotherapy not only sufficiently activates the host immune system, but also reprograms immunosuppressive microenvironment, representing a new generation approach to treat cancer. Herein, we demonstrated targeted photo- and immune-active nanoplatform termed NLG919@HA-Ce6 simultaneously elicit efficient immunogenic cell death (ICD) using photosensitizer Ce6 modulate tryptophan metabolic pathway an indoleamine 2,3-dioxygenase (IDO) inhibitor NLG919 for...
Periodontitis is a prevalent chronic inflammatory disease that destroys the periodontal supporting tissues, impinges on oral health, and correlated with an increased risk of systemic disease. Currently, main drug treatment antibiotic therapy; however, therapy still has various drawbacks such as bacterial resistance, low bioavailability burst release. It noteworthy local use non-antibiotic drugs sustained release characteristics can effectively overcome these problems. been documented...
The objective of this study was to investigate the effects low doses organic trace minerals (iron, copper, manganese, and zinc) on productive performance, egg quality, yolk tissue mineral retention, fecal excretion laying hens during late period.A total 405 healthy (HY-Line White, 50-week-old) were randomly divided into 3 treatments, with 9 replicates per treatment 15 birds replicate. dietary treatments included feeding a basal diet + inorganic at commercial levels (CON), 1/3 (ITM),...
Iron (Fe) homeostasis is critical for plant growth, development, and stress responses. Fe levels are tightly controlled by intricate regulatory networks in which transcription factors (TFs) play a central role. A series of basic helix-loop-helix (bHLH) TFs have been shown to contribute homeostasis, but the layers beyond bHLH remain largely unclear. Here, we demonstrate that SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE (SPL) TF SlSPL-CNR negatively regulates Fe-deficiency responses tomato (Solanum...
Abstract Autoluminescent plants have been genetically modified to express the fungal bioluminescence pathway (FBP). However, a bottleneck in precursor production has limited brightness of these luminescent plants. Here, we demonstrate effectiveness utilizing computational model guide multiplex five-gene-silencing strategy by an artificial microRNA array enhance caffeic acid (CA) and hispidin levels By combining loss-of-function-directed metabolic flux with tyrosine-derived CA pathway,...
Abstract Highly efficient and stimulus‐responsive nanomedicines for cancer treatment are currently receiving tremendous attention. In this study, an acid‐triggered charge‐reversible graphene‐based all‐in‐one nanocomplex is appropriately designed by surface modification with multilayer polymers simultaneous co‐transportation of photosensitizer indocyanine green (ICG) oligonucleotide inhibitor miR‐21 (miR‐21i) to achieve highly genetic phototherapy in a controlled manner. The (denoted as...
Plants have evolved complex physiological and biochemical mechanisms to adapt a heterogeneous soil phosphorus environment. PHOSPHATE2 (PHO2) is phosphate (Pi) starvation-signaling regulator involved in maintaining Pi homeostasis plants. Arabidopsis (Arabidopsis thaliana) PHO2 targets PHOSPHATE TRANSPORTER1 (PHT1) PHO1 for degradation, whereas rice (Oryza sativa) thought mediate TRANSPORTER TRAFFIC FACILITATOR1 degradation. However, it unclear whether how post-translationally regulated. Here,...
It remains a conundrum to reconcile the contradiction between effective tumor retention and deep intratumor infiltration for nanotherapeutics due sophisticated drug delivery journey. Herein, we reported an acid-sensitive supramolecular nanoassemblies (DCD SNs) based on multivalent host-gest inclusions of two polymer conjugates conquering diverse physiological blockages amplifying therapeutic efficacy. The multiple repetitive units hydrophilic backbone reinforced binding affinity induced...