A5080088434- Influenza Virus Research Studies
- Respiratory viral infections research
- Lung Cancer Treatments and Mutations
- Animal Disease Management and Epidemiology
- Vibrio bacteria research studies
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Biosensors and Analytical Detection
- Virology and Viral Diseases
- Treatment of Major Depression
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Salmonella and Campylobacter epidemiology
- Neuroendocrine Tumor Research Advances
- interferon and immune responses
- Nosocomial Infections in ICU
- Syphilis Diagnosis and Treatment
- Landslides and related hazards
- HIV-related health complications and treatments
Southern Medical University
2016-2025
Shandong First Medical University
2025
Shandong Tumor Hospital
2025
Guangdong Medical College
2024
South China University of Technology
2023-2024
Zhuhai People's Hospital
2021
Zhejiang Center for Disease Control and Prevention
2005-2018
Foshan Second People's Hospital
2018
Centers for Disease Control and Prevention
2007-2008
Kyushu University
1994
In this work, a series of bifunctional PD-L1/CD73 (cluster differentiation 73) small-molecule inhibitors were designed and synthesized. Among them,
Stroke-associated pneumonia (SAP) is a major stroke complication. Oral microorganisms are important contributors to SAP. Here, we aimed investigate whether oral hygiene associated with early SAP (<72 h of onset) in patients ischemic stroke. We performed an observational study 331 acute from 2 medical centers. A series assessments were evaluate the neurological status, Beck Assessment Scale (BOAS), and habits hygiene. Univariate binary logistic regression analyses conducted identify risk...
In a previous study (Y. Koga, M. Sasaki, H. Yoshida, Wigzell, G. Kimura, and K. Nomoto, J. Immunol. 144:94-102, 1990), we demonstrated that the expression of gp160, precursor form envelope glycoprotein human immunodeficiency virus type 1, in CD4+ cells causes downregulation surface CD4 single-cell killing by forming intracellular gp160-CD4 complex. present investigated events lead to cell death expressing gp160. We found apoptosis is induced undergoing death. Moreover, even clone, which...
Large-scale Hand, Foot, and Mouth Disease (HFMD) outbreaks have frequently occurred in China since 2008, affecting more than one million children causing several hundred deaths every year. The pathogens of HFMD are mainly human enteroviruses (HEVs). Among them, enterovirus 71 (HEV71) coxsackievirus A16 (CVA16) the most common HFMD. However, other HEVs could also cause To rapidly detect HEV71 CVA16, ensure detection all HFMD, two real-time hybridization probe-based RT-PCR assays were...
Ruthenium (Ru) complexes are currently the focus of substantial interest because their potential application as chemotherapeutic agents with broad anticancer activities. This study investigated in vitro and vivo activities mechanisms two Ru complexes—2,3,7,8,12,13,17,18-Octaethyl-21H,23H-porphine Ru(II) carbonyl (Ru1) 5,10,15,20-Tetraphenyl-21H,23H-porphine (Ru2)—against human hepatocellular carcinoma (HCC) cells. These effectively inhibited cellular growth three cells, IC50 values ranging...
In this work, we rationally designed, synthesized, and evaluated a series of novel d-(+)-biotin-conjugated PD-L1 inhibitors for targeted cancer therapy. Among them, SWS1 exhibited the highest anti-PD-1/PD-L1 activity with an IC50 1.8 nM. addition, dose-dependently promoted tumor cell death in HepG2/Jurkat co-culture model. Importantly, displayed high antitumor efficacy B16-F10 mouse model growth inhibition 66.1%, which was better than that P18 (44.3%). Furthermore, exerted effects by...
Abstract This report describes the genetic characterization of 297 wild-type measles viruses that were isolated in 24 provinces China between 1995 and 2003. Phylogenetic analysis N gene sequences showed all isolates belonged to genotype H1 except 3 isolates, which A. The nucleotide sequence predicted amino acid homologies 294-genotype strains 94.7%–100% 93.3%–100%, respectively. divided into 2 clusters, differed by approximately 2.9% at level. Viruses from both clusters distributed...
Abstract Non-small cell lung cancer (NSCLC) is one of the most fatal types with significant mortality and morbidity worldwide. MicroRNAs (miRs) have been confirmed to positive functions in NSCLC. In present study, we try explore role miR-758 proliferation, migration, invasion, apoptosis NSCLC cells by regulating high-mobility group box (HMGB) 3 (HMGB3.) adjacent tissues were collected. Reverse transcription quantitative PCR (RT-qPCR) was employed detect expression HMGB3 tissues, BEAS-2B...
At 4 wk after intraperitoneal inoculation of murine cytomegalovirus (MCMV) in adult BALB/c mice, MCMV remained detectable only the salivary glands. When T cells these mice were activated by a single injection anti-CD3 epsilon monoclonal antibody, died interstitial pneumonitis at 24-48 h injection, accompanied elevation serum levels TNF-alpha and IFN-gamma. However, undetectable lungs during period. Simultaneous cyclosporin A reduced such effects anti-CD3. In conclusion, although presence...
Abstract A real‐time polymerase chain reaction assay was initially developed in China to detect mumps genome. The primers and TaqMan‐MGB probe were selected from regions of the hemagglutinin gene virus. for PCR evaluated by both laboratories UK using three different pieces equipment, LightCycler (Roche), MJ DNA Engine Option® 2 (BIO‐RAD) TaqMan (ABI Prism) on samples. performed with either a one‐step (China) or two‐step (UK) process. sensitivity (10 copies) estimated serial dilution...
Cytomegalovirus (CMV) causes severe clinical manifestations in immunocompromised hosts; however, it remains unclear whether the virus itself is a cause of immunosuppression or involved as an opportunistic bystander pathogen. This study was performed to elucidate effect CMV infection on host's immune system. The double-positive thymocytes BALB/c mice inoculated with sublethal dose murine (MCMV) were extensively depleted by 10-micrograms amount anti-CD3 monoclonal antibody, while such unable...
Aims: Real-time reverse transcription-polymerase chain reaction (RT-PCR) assay based on a TaqMan-minor groove binder (MGB) probe was developed for the rapid detection of avian influenza virus subtype H5. Methods and Results: Conserved regions in haemagglutinin genes viruses H5 served as targets primers TaqMan-MGB design. Concentrations were optimized to improve sensitivity specificity reactions. A plasmid containing gene constructed vitro transcribed quantitative copy numbers target gene....
In this work, a novel series of heterotricyclic DNA-PK inhibitors were rationally designed, synthesized, and assessed for their biological activity. the biochemical assay, most compounds displayed potent enzymatic activity, with IC
To study the effect of Yinghua Pinggan granule (YHPG) against influenza A/H1N1 virus in vivo and on immunologic function infected mice. The intranasal infection was adopted ICR mouse to establish pneumonia model. At 3rd 7th day after infection, lung index pathologic changes tissues mice were detected. Realtime PCR flow cytometry employed observe load levels CD4+, CD8+, CD4+/CD8+ peripheral blood. result showed that at YHPG (15, 30 g x kg(-1)) can significant decrease with virus, alleviate...
To study the effect and underlying mechanism of Mahuang Tang against influenza A virus in vitro， virus-infected Madin-Darby canine kidney(MDCK) cells were used as carrier this to detect median tissue culture-infective dose(TCID₅₀) strains(A/PR8/34) on MDCK with cytopathic effect(CPE) assay. Blocking invading host anti-influenza biosynthesis two different administration methods， then methyl thiazolyl tetrazolium(MTT) assay was utilized determine antiviral effective rate(ER)， efficacious...