A5029286871- Extracellular vesicles in disease
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Genetics, Aging, and Longevity in Model Organisms
- Cannabis and Cannabinoid Research
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- RNA and protein synthesis mechanisms
- Nanopore and Nanochannel Transport Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Metal complexes synthesis and properties
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- Sperm and Testicular Function
- Cancer-related molecular mechanisms research
- Tryptophan and brain disorders
- interferon and immune responses
- Mesenchymal stem cell research
- Ginseng Biological Effects and Applications
- Circadian rhythm and melatonin
Institute of Special Animal and Plant Sciences
2016-2025
Chinese Academy of Agricultural Sciences
2016-2025
Xiangya Hospital Central South University
2023
Central South University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Yantai University
2019
University of Colorado Boulder
2014-2017
Sichuan University
2013
West China Hospital of Sichuan University
2013
Shandong Agricultural University
2011
Despite the approval of several artificial nanotherapeutics for treatment triple-negative breast cancer (TNBC), significant challenges, including unsatisfactory therapeutic outcomes, severe side effects, and high cost large-scale production, still restrict their long-term application. In contrast, plant-derived extracellular vesicles (PEVs) exhibit promising potential in therapy due to negligible systemic toxicity, bioavailability cost- effectiveness. this study, we developed an alternative...
As the leading nanodevice candidate, single-walled carbon nanotubes (SWNTs) have potential therapeutic applications in gene therapy and novel drug delivery. We found that SWNTs can inhibit DNA duplex association selectively induce human telomeric i-motif formation by binding to 5′-end major groove under physiological conditions or even at pH 8.0. SWNT was studied UV melting, NMR, S1 nuclease cleavage, CD, competitive FRET methods. These results suggest might intriguing modulate structures...
The toll-like receptor TLR4 is involved in neuropathic pain and drug reward reinforcement. opioid inactive isomers (+)-naltrexone (+)-naloxone act as antagonists, reversing reducing cocaine However, how these agents modulate signalling not clear. Here, we have elucidated the molecular mechanism of on signalling.BV-2 mouse microglial cell line, primary rat microglia peritoneal macrophages were treated with LPS inhibitors. Effects measured using Western blotting, luciferase reporter assays,...
The increasing worldwide demand for carbon nanotubes (CNTs) and concern regarding how to safely develop use CNTs are requiring a low-cost, simple, highly sensitive CNT detection assay toxicological evaluation environmental monitoring. However, this goal is still far from being achieved. All the current techniques not applicable automation field analysis because they dependent on expensive special instruments complicated sample preparation. On basis of capability single-walled (SWNTs)...
Sorafenib (Nexavar) is a broad-spectrum multikinase inhibitor that proves effective in treating advanced renal-cell carcinoma and liver cancer. Despite its well-characterized mechanism of action on several established cancer-related protein kinases, sorafenib causes variable responses among human tumors, although the cause for this variation unknown. In an unbiased screening oncology drug library, we found activates recruitment ubiquitin E3 ligase Parkin to damaged mitochondria. We show...
Opioid addiction is a chronically relapsing disorder that causes critical public health problems. Currently, there lack of effective drug treatment. Herein, one cannabidiol derivative, CIAC001, was discovered as an agent for treating morphine-induced addiction. In vitro, CIAC001 exhibited significantly improved anti-neuroinflammatory activity with lower toxicity. vivo, ameliorated the withdrawal reaction, behavioral sensitization, and conditional position preference by inhibiting microglia...
The NanoCoulter Counter provided reliable evidence for the assessment of different EVs isolation method, which contributed to development EV-based disease biomarkers and treatments.
Background: Deer antlers, unique among mammalian organs for their ability to regenerate annually without scar formation, provide an innovative model regenerative medicine. This study explored the potential of exosomes derived from antler mesenchymal stem cells (AMSC-Exo) enhance skin wound healing. Methods: We proliferation, migration and angiogenesis effects AMSC-Exo on HaCaT HUVEC cells. To investigate repairing effect AMSC-Exo, we established a full-thickness injury mouse model. Then...
Cannabidiol (CBD), a phytocannabinoid from Cannabis sativa, is renowned for its nonpsychoactive properties and therapeutic potential. However, clinical application limited by nonselective cytotoxicity, affecting microglia, oligodendrocytes, other cells. To address this, subcellular organelle-targeting strategies were explored to minimize off-target effects enhance CBD's index. Three organelle-specific conjugates targeting mitochondria, endoplasmic reticulum, lysosomes synthesized. Among...
The activation of the cyclic GMP‐AMP synthase‐stimulator interferon genes (cGAS‐STING) pathway has shown promise in enhancing antitumor immunity. However, involved de novo transcription and translation processes, which delays immune responses. Besides, rapid clearance secondary messenger (cGAMP) by extracellular hydrolase limits its availability, attenuating STING signaling resulting insufficient therapeutic efficacy. Herein, we constructed a DNA‐based nanocomplex, could restore cell‐cell...
The activation of the cyclic GMP‐AMP synthase‐stimulator interferon genes (cGAS‐STING) pathway has shown promise in enhancing antitumor immunity. However, involved de novo transcription and translation processes, which delays immune responses. Besides, rapid clearance secondary messenger (cGAMP) by extracellular hydrolase limits its availability, attenuating STING signaling resulting insufficient therapeutic efficacy. Herein, we constructed a DNA‐based nanocomplex, could restore cell‐cell...
Single-walled carbon nanotubes (SWNTs) binding to human telomeric i-motif DNA can significantly accelerate S1 nuclease cleavage rate by increasing the enzyme turnover number.
Abstract All messenger‐RNA (mRNA) molecules in eukaryotic cells have a polyadenylic acid [poly(rA)] tail at the 3′‐end and human poly(rA) polymerase (PAP) has been considered as tumor‐specific target. A ligand that is capable of recognizing binding to mRNA might interfere with full processing by PAP can be potential therapeutic agent. We report here for first time single‐walled carbon nanotubes (SWNTs) cause single‐stranded self‐structure form duplex structure, which studied UV melting,...
The opioid inactive isomer (+)-naltrexone is one of the rare Toll-like receptor 4 (TLR4) antagonists with good blood–brain barrier (BBB) permeability, which a lead promising potential for treating neuropathic pain and drug addiction. (+)-Naltrexone targets lipopolysaccharides (LPS) binding pocket myeloid differentiation protein 2 (MD-2) blocks innate immune TLR4 signaling. However, details molecular interactions its derivatives MD-2 are not fully understood, hinders ligand-based discovery....
Velvet antler is one of the most important animal medicines or functional foods widely used in East Asia for many centuries, which has several biological activities including anti-ageing and health promotion. To date, mechanism underlying these effects velvet studied by its protein polypeptide components. Few studies have been reported function other components antler. Herein, C. elegans as model to dissect how none affect vivo oxidative stress. Methanol extracts (MEs) from few extends...
Abstract Artemisinin and its derivatives have been the frontline drugs for treating malaria. In addition to antiparasitic effect, accumulating evidence shows that artemisinins can alleviate neuroinflammatory responses in central nervous system (CNS). However, precise mechanisms underlying their anti‐neuroinflammatory effects are unclear. Herein we attempted delineate molecule target of artemisinin microglia. vitro protein intrinsic fluorescence titrations saturation transfer difference...
To analyze the incidence of PICC associated venous thrombosis. predict risk factors validate best predictive model in predicting Consecutive oncology cases 341 who initially naive intended to be inserted central catheter for chemotherapy, were recruited our dedicated intravenous lab. All patients used same gauge catheter, Primary endpoint was thrombosis formation, secondary infusion termination without Two excluded. 339 divided into group 59 (17.4%) and non-thrombosis Group 280 (82.6%),...
Postoperative cognitive dysfunction (POCD) is a severe complication of cardiopulmonary bypass (CPB) and has common characteristics such as acute dysfunction, impaired memory, inattention. Mesenchymal stem cells (MSCs) are multipotent that have therapeutic potentials mainly through paracrine action via secreting growth factors cytokines. Exosomes one the important been reported potential cell-free therapy for treatment autoimmune central nervous system disorders. In this study, we examined...