A5076789937- Inflammasome and immune disorders
- Ferroptosis and cancer prognosis
- Frailty in Older Adults
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Stoma care and complications
- Telomeres, Telomerase, and Senescence
- Nutrition and Health in Aging
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- FOXO transcription factor regulation
- Heat shock proteins research
- IL-33, ST2, and ILC Pathways
First Affiliated Hospital of Wenzhou Medical University
2022-2024
Wenzhou Medical University
2022-2024
Cellular senescence is associated with tumorigenesis, and the subtype prognostic signatures of senescence-related genes (SRGs) in tumor microenvironment (TME) gut microbiota have not been fully determined. Analysis 91 SRGs obtained from GSEA MSigDB, mRNA sequencing Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) databases enabled identification two distinct molecular types colorectal cancer (CRC). Patient samples were clustered into subtypes, Kaplan-Meier survival analyses...
Background. Pyroptosis is a form of cell death characterized by swelling and plasma membrane bubbling in association with inflammatory immune responses. To date, the between pyroptosis colorectal cancer remains unclear. We aimed to establish novel pyroptosis-associated model for prognosis cancer. Methods. Pyroptosis-related genes were extracted using Gene Set Enrichment Analysis. A least absolute shrinkage selection operator regression was constructed identify pyroptosis-related gene...
Background Malnutrition often occurs in patients with colorectal cancer. This study aims to develop a predictive model based on GLIM criteria for cancer who underwent radical surgery. Methods From December 2015 May 2021, surgery at our center were recruited this study. We prospectively collected data GLIM-defined malnutrition and other clinicopathological characteristics. Using Cox regeneration, we developed novel nomogram prognostic prediction, which was validated compared traditional...
Abstract Purpose This study analyzed the oncologic outcomes of patients with low rectal cancer undergoing intersphincteric resection (ISR) compared those underwent APR to evaluate safety ISR. Methods enrolled 149 ISR and 166 receiving for LRC from January 2010 December 2020. The exclusion criterion included neoadjuvant therapy or other malignant tumors. Moreover, this used propensity score matching reduce possible confounding factors. Results After comparing 123 each group, comparable...