A5100750137- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Psoriasis: Treatment and Pathogenesis
- Circular RNAs in diseases
- Bone health and treatments
Tianjin Medical University General Hospital
2016-2024
Endometrial cancer (EC) is a common malignancy of the female reproductive system, with an escalating incidence. Recurrent/metastatic EC presents poor prognosis. The interaction between long non-coding RNA (lncRNA) HOTAIR and polycomb repressive complex 2 (PRC2) induces abnormal silencing tumor suppressor genes, exerting pivotal role in tumorigenesis. We have previously discovered AC1Q3QWB (AQB), small-molecule compound targeting HOTAIR-EZH2 interaction. In present study, we unveil that AQB...
Endometrial carcinoma (EC) is one of the most common malignancies female reproductive system. Migration and invasion inhibitory protein (MIIP) gene was recently discovered candidate tumor suppress which located at chromosome 1p36.22. 1p36 deletion found in many types including EC. In present study, we will determine role mechanism MIIP EC metastasis. Immunohistochemistry used to measure expression normal tissue. Both gain-of-function (infection) loss-of-function (siRNA) assays were alter...
Cervical cancer is one of the most common malignant neoplasms in gynecology. Protein tyrosine kinase 7 (PTK7) with an inactive domain important regulator multiple Wnt pathways under normal and various pathological conditions overexpressed tumors; however, clinical biological significance PTK7 cervical still unknown. In present study, protein expression level was detected patient samples, relationship between clinicopathological features analyzed. addition, Kaplan-Meier method performed to...
Endometrial carcinoma (EC) is one of the most common gynecological malignant tumors, but its underlying pathogenic mechanisms are largely obscure. Interleukin-22 (IL-22), cytokine in tumor immune microenvironment, was reported to be associated with progression. Here, we aimed investigate regulation IL-22 endometrial carcinoma. Enzyme-linked immunosorbent assay (ELISA) analysis done 27 controls and 51 patients EC. We examined proliferative potential, cycle progression, signaling pathways...
Endometrial carcinoma (EC) remains one of the most prevalent forms cancer to impact female reproductive system, yet mechanisms governing its development and progression are incompletely understood. We, therefore, sought assess relevance SOX8 EC patient prognosis. Array comparative genomic hybridization (aCGH) was performed using samples from 50 patients with EC. Samples were separated based upon whether positive for lymph node metastasis (LN+ LN-, respectively). Based on our initial results,...